Xinnan Wang Lab

Clu1/Clu form mitochondria-associated granules upon metabolic transitions and regulate mitochondrial protein translation via ribosome interactions Author summary Mitochondria are essential cellular organelles that perform many important roles in regulating metabolism. They are dynamic in form, function and composition which is crucial to maintai...

Delighted to share our latest work looking at the role of the RNA-binding proteins Clu1 (yeast)/Clu (flies) in regulating the translation of #mitochondria proteins. Really interesting regulator of mito biology.

Huge, long-running effort by PDRA Leonor Miller-Fleming 👏
dx.plos.org/10.1371/jour...

16.07.2025 11:35 — 👍 21    🔁 9    💬 1    📌 0

2025 Stanford Biology Preview Program Application The Stanford Biology Preview Program (BPP) aims to support scholars through the PhD application process. The Stanford BPP offers virtual workshops to provide insight into the Stanford Biology PhD Prog...

Please share! We are accepting applications for the Biology Preview Program, which aims to make the PhD application process accessible and work with students to strenghten applications. Participants will receive a fee waiver, work 1:1 w/ a mentor, and meet w/faculty. Link: forms.gle/1xBShmvot5Vr...

16.06.2025 18:43 — 👍 15    🔁 16    💬 0    📌 0

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease - Nature Communications Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondri...

Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...

01.06.2025 01:16 — 👍 40    🔁 16    💬 2    📌 0

Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.

Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...

31.05.2025 06:24 — 👍 29    🔁 13    💬 2    📌 1

Silencing mitochondrial gene expression in living cells Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...

Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d

23.05.2025 19:23 — 👍 115    🔁 34    💬 0    📌 1

Congratulations Furkan!

12.05.2025 19:25 — 👍 0    🔁 0    💬 1    📌 0

Flyer for the 2025 Next Generation Faculty Symposium (including QR code in top right corner). This symposium highlights the work of exceptional early-career scientists in the broad field of quantitative biological and biomedical sciences, with a track record of excellence in research, leadership, mentorship, and community engagement. These early career scientists are preparing to launch a faculty search. Applications are due May 30th, 2025.

Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)

21.04.2025 19:21 — 👍 93    🔁 84    💬 2    📌 4

ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution ARMC1 partitions between distinct outer mitochondrial membrane complexes and the cytosol to control mitochondrial distribution.

ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution | Science Advances www.science.org/doi/10.1126/...

10.04.2025 15:10 — 👍 3    🔁 0    💬 0    📌 0

Small molecules restore mutant mitochondrial DNA polymerase activity - Nature An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.

New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...

09.04.2025 16:30 — 👍 25    🔁 13    💬 0    📌 1

TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux Nature Metabolism, Published online: 08 April 2025; doi:10.1038/s42255-025-01250-9Garbincius et al. show that the mitochondrial protein TMEM65 is required to mediate NCLX-dependent mitochondrial calcium efflux, thus fine-tuning mitochondrial function and cellular homeostasis

08.04.2025 14:29 — 👍 6    🔁 4    💬 0    📌 0

Mitochondria in the Nervous System The brain is a high energy-demanding tissue with an heterogenous cellular composition. Most of the energy consumed is used for maintenance of neuronal synaptic transmission, and neurons almost exclus…

Thrilled to announce that the registration for the EMBO workshop „Mitochondria in the Nervous System“ is now open.
Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland!
meetings.embo.org/event/25-mit...

04.04.2025 13:44 — 👍 33    🔁 16    💬 0    📌 2

Beautiful paper on mitochondrial DNA (mtDNA) stress sensing, from our postdoc Alva Sainz @signscaztl.bsky.social of her Ph.D work in the Shadel lab!

28.01.2025 17:40 — 👍 13    🔁 7    💬 1    📌 0

Impressive #MitoSky 🦋 in Japan! #MBSJ2024

30.11.2024 03:21 — 👍 4    🔁 0    💬 0    📌 0

We had a nice lab visit from Gordon Freedman, the mastermind of MitoWorld - seems a great initiative: mitoworld.org

22.11.2024 01:40 — 👍 3    🔁 0    💬 0    📌 0

Hi everyone, really enjoy the fresh air here and meeting new people! Thanks to @colemanlab.bsky.social for the nudge! We study everything related to mitochondria. Hope to form more connections and conversations! Some blue sky pics from a fantastic nature conference on mito and immunity in September.

20.11.2024 02:01 — 👍 15    🔁 3    💬 0    📌 0

Welcome to @xinnanwanglab.bsky.social - a star of mitochondrial dynamics in neurons!😀

10.11.2024 23:13 — 👍 3    🔁 1    💬 1    📌 0

Thank you so much Michael 😊, and for the introduction!

11.11.2024 01:02 — 👍 1    🔁 0    💬 0    📌 0