Giampaolo Trivellin

Distinguishing benign from pathogenic duplications involving GPR101 and VGLL1-adjacent enhancers in the clinical setting with the bioinformatic tool POSTRE Background Structural variants (SVs) that disrupt topologically associating domains (TADs) can cause disease by rewiring enhancer-promoter interactions. Duplications involving GPR101 are known to caus...

🥳 Happy to share the results of an ongoing work in which we are applying POSTRE (our tool for SV interpretation github.com/vicsanga/Pos...) to better comprehend the cause of X-LAG tumors, a pituitary disorder responsible for an overgrowth condition 🧬. Preprint: www.medrxiv.org/content/10.1...
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Distinguishing benign from pathogenic duplications involving GPR101 and VGLL1-adjacent enhancers in the clinical setting with the bioinformatic tool POSTRE Background Structural variants (SVs) that disrupt topologically associating domains (TADs) can cause disease by rewiring enhancer-promoter interactions. Duplications involving GPR101 are known to caus...

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Our new preprint is out! Proud to have contributed to this collaborative study. We identified the enhancer cluster responsible for GPR101 overexpression in X-linked acrogigantism (X-LAG) - a key step toward understanding this rare pituitary disorder 🧠🧬
🔗 www.medrxiv.org/content/10.1...

📣 Thrilled to announce our next speaker for the EYES Annual Meeting in Milan – Prof. Constantine Stratakis!

💡 Register & submit your abstract! ⏳

🇮🇹 Join us in Milan!

@esendocrinology.bsky.social @ksaravinovska.bsky.social

Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells Enhancers are key gene regulatory elements that ensure the precise spatiotemporal execution of developmental gene expression programmes. However recent findings indicate that approaches to identify en...

Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social‬:
www.biorxiv.org/content/10.1...

🧵 below

High prevalence of deleterious germline variants in cancer risk genes among subjects with young-onset, sporadic pituitary macroadenomas https://www.medrxiv.org/content/10.1101/2025.05.15.25327006v1

🚨 New Neuroendo Watch by EYRC – Highlight Alert! 🚨

We spotlight a study revealing how cholesterol metabolism drives dopamine agonist resistance in prolactinomas. 🧪🧠

Full post with takeaways on our LinkedIn page:
www.linkedin.com/company/enea-young-researcher-committee

The Oldest University In Every Country In The World

brilliantmaps.com/oldest-un...

Butterflies on a blue sky

THREAD

The numbers are in. @bsky.app research sharing volumes vs X Formerly Twitter

In March 2024, on most days, Bluesky hosts more posts linked to research published in 2025 than X.

By quite a lot.

Release the Kraken...

#AcademicSky #HigherEd #Altmetrics
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La storia rara di Sonia e Eric pionieri per forza e per amore Un’avventura scientifica che ha come ingredienti la minaccia incombente di una malattia fatale, la decisione di reinventarsi entrambi biologi e l’obiettivo di silenziare i prioni.

www.osservatorioterapieavanzate.it/terapie-avan...

🚀 EYRC Neuroendo Watch

We highlight a study in Endocrine, offering new insights into MEN5: tinyurl.com/25n94ac3

📌First reported case of pit-gigantism linked to a germline MAX mutation
📌Myelolipoma as a new disease association in MEN5
📌Expansion of the phenotype beyond PPGLs

By @gp83.bsky.social

Welcome to the ENEA Young Researchers Committee (EYRC), a subcommittee of ENEA dedicated to supporting early career scientists in neuroendocrinology.

✨ Our Mission:
🔹 Strengthening ENEA’s visibility
🔹 Representing early career researchers
🔹 Organizing symposia & workshops
🔹 And much more ...

When your weekend’s pancake turns out to look something like a #zebrafish embryo during the gastrula period 🤣
@zebrafishrock.bsky.social

Christmas snowball!

Giampaolo Trivellin on LinkedIn: Post doc announcement 🔬 🧫 🧬 We are #hiring! 🔬 🧫 🧬 An exciting opportunity awaits at the Humanitas Research Hospital in the Translational Endocrinology and Metabolism Lab! We…

www.linkedin.com/posts/activi...

How maverick rewilders are trying to turn back the tide of extinction The long read: A handful of radical nature lovers are secretly breeding endangered species and releasing them into the wild. Many are prepared to break the law and risk the fury of the scientific esta...

www.theguardian.com/environment/...

Why Is Every Human Being Riddled With Genetic Errors? Your body is a collection of cells carrying thousands of genetic mistakes accrued over a lifetime—many harmless, some bad and at least a few that may be good for you

Why Is Every Human Being Riddled With Genetic Errors? www.smithsonianmag.com/science-natu...

Addgene: The First Twenty Years Twenty years have gone by fast! Join us to share some highlights of Addgene and our community as we close out our 20th anniversary celebration.

Did you know 2024 was our 20th anniversary? We're closing it out by sharing a brief history of Addgene, with commentary from our incredible community.
Read it below!

blog.addgene.org/add...

Opinion | Pfizer Stopped Us From Getting Ozempic Decades Ago (Gift Article) Researchers identified one key breakthrough for GLP-1 drugs in the 1980s, but Pfizer walked away.

www.nytimes.com/2024/12/25/o...

Left-right symmetry?

Density Gradient Centrifugation!

Scientists Warn of an 'Unprecedented Risk' From Synthetic 'Mirror Life,' Built With a Reverse Version of Natural Proteins and Sugars So-called mirror cells could rampage through our ecosystems, food supply and immune systems, experts say, potentially without existing barriers to protect against them

www.smithsonianmag.com/smart-news/s...