Albert Martín

@dbernardo-gut.bsky.social @uva-es.bsky.social @aegastro @sepdigestiva @seeceliaca @celiacscat @CeliacosMadrid @FACEceliacos @infoceliaco @CIBER_ISCIII

Restoration of the lamina propria duodenal immune infiltrate in gluten-free diet treated celiac patients despite persistent villous atrophy Most celiac disease patients despite following a gluten-free diet show mucosal alterations and/or symptomatology. However, duodenal immune infiltrate norma

9/9💡 Clinical message:
Negative antibodies ≠ mucosal healing.
New biomarkers are needed to monitor mucosal recovery in celiac disease.
🔗 Read the full paper: doi.org/10.1093/cei/...

8/9 Key takeaway:
📍 A strict GFD normalizes duodenal immune balance but not necessarily mucosal structure.
📍 IEL–epithelium interactions (esp. γδ T cells) may sustain the residual damage.

7/9 Duration of the gluten-free diet correlated with:
⬆ Gut-homing markers (α4β7, CCR9, CCR2)
⬆ Effector T cells
⬇ Regulatory T cells
➡ Longer GFD = progressive immune normalization, even if mucosal healing lags behind.

6/9 So, while the tissue architecture remained damaged, the immune environment of the lamina propria was restored.
This suggests that persistent atrophy may originate from the epithelial layer, not from immune cells in the lamina propria.

5/9 Surprisingly, after >1 year on a GFD (average 7 years):
⚪ Serology was negative
⚪ 68% still had villous atrophy
⚪ Yet — the lamina propria immune infiltrate looked normal, nearly identical to controls

4/9 At diagnosis, CD patients had:
🔸 Expansion of NK, ILC, B, Treg and Tγδ cells
🔸 Reduced CD4+ and CD8+ T cells
🔸 Strong pro-inflammatory phenotype (↑ Fas, CD38, CD2)
Classic picture of active mucosal inflammation.

3/9 Researchers from Valladolid (Spain) analyzed duodenal biopsies from:
🔹 6 controls
🔹 6 newly diagnosed CD patients
🔹 19 GFD-treated CD patients
Using spectral flow cytometry, they mapped >70 immune cell subsets in the duodenal mucosa.

2/9 Celiac disease (CD) affects ~1% of the population.
Even after years on a strict gluten-free diet (GFD), many patients still show intestinal villous atrophy — but the reasons remain unclear.

🧵1/9 📢 New study in Clinical and Experimental Immunology (Fiz-López et al., 2025):
“Restoration of the duodenal lamina propria immune infiltrate in celiac patients on a gluten-free diet despite persistent villous atrophy.”
Here’s what they found 👇

YouTube video by Universitat de Barcelona Elisabet Tintó, premiada per una descoberta sobre l’estratègia de defensa del paràsit de la malària

#RecercaUB | 🦟 La investigadora Elisabet Tintó, en la seva tesi doctoral a la UB, va fer una descoberta sobre l’estratègia de defensa del paràsit que provoca la malària.

➡️ Ha guanyat el Premi Ramon Margalef del Consell Social i de la Fundació Bosch i Gimpera

tuit.cat/zqsn1

@isglobal.org

El Dr Albert Martin @amartin88.bsky.social nos explica en el congreso de @aegastro.es la utilidad de la citometria de flujo en diferenciar los pacientes con #celiaquia 🌾 de bajo grado respecto a no celiacos. 😊

La Dra. Carme Loras 👩‍⚕️ de @Mutua_Terrassa 🏥 nos explica las estenosis en la Enfermedad de Crohn 🤒, ¿dilatación, prótesis, otros tratamientos endoscópicos o cirugía? @aegastro.es #AEG2025

Understanding the therapeutic toolkit for inflammatory bowel disease Nature Reviews Gastroenterology & Hepatology, Published online: 31 January 2025; doi:10.1038/s41575-024-01035-7The management of inflammatory bowel disease (IBD) continues to evolve. This Review is a practical guide on the therapeutic toolkit for IBD,…

ICYMI: New online! Understanding the therapeutic toolkit for inflammatory bowel disease

Histology of the Upper Gastrointestinal Tract, Morphometry and Lymphocyte Subpopulations of the Duodenal Mucosa: Insights from Healthy Individuals The upper oesophagogastrointestinal (UEGI) tract histology, intestinal morphometry and lymphocyte subpopulations of healthy people is scarcely known. In research studies of inflammation involving the ...

5/ Want to learn more?
📖 Read the full study here: www.mdpi.com/1422-0067/26...
💬 Let’s discuss: What should be the gold standard for a healthy gut mucosa?
#Gastroenterology #Immunology #collaborativeresearch

4/ Why does this matter?
🔹 Our study sets a “gold standard” for the normal histology of the upper digestive tract.
🔹 The immune profile of a truly healthy duodenum should guide future research and diagnostics.

3/ Key findings:
✅ Healthy individuals had lower duodenal intraepithelial lymphocyte (IEL) counts than patients with gastroesophageal reflux disease (GERD) (15 vs. 19.5 per 100 enterocytes, p = 0.004).
✅ CD4+ T cells decreased (p = 0.008) & CD8+ T cells increased (p = 0.014) in GERD.

2/ Most studies lack true healthy controls when investigating inflammatory diseases of the upper gastrointestinal tract. We rigorously selected asymptomatic individuals to establish a reference for future research.
🔬 #GutHealth #CeliacDisease #Endoscopy

1/ What is normal in the upper digestive tract?🧐
Our latest study in @IJMS maps the histology of the esophagus, stomach, and duodenum, as well as morphometry and lymphocyte subpopulations of the duodenal mucosa in truly healthy individuals. A crucial step in defining a “gold standard” of normality🧵👇

ICYMI: New online! Coeliac disease: complications and comorbidities

Vesícules extracel·lulars derivades de cèl·lules mare com a nou agent terapèutic per al tractament de la malaltia de Crohn 🧫🔬🧪🧬 Estudi molt interessant presentat a #SCD2025 @SCDigestologia @laura_clua @cserena79 @manye_j @IBODI_Group @IBDcanruti

AI applications in biomedicine research 🔬🧬💻🤖 Very interesting talk! Excellent presentation by @Davide__Cirillo at #SCD2025 @SCDigestologia @BSC_CNS

Leishmania 🦠 in patients with IBD 🤒 doesn't seem to follow a complicated clinical course, even in those with localized cutaneous leishmania who do not discontinue biological therapy 💉💊 after infection diagnosis.

Leishmaniasis in Patients With Inflammatory Bowel Disease: A National Multicenter Study of GETECCU Background Leishmaniasis (LI) is a vector-borne illness caused by a protozoan of the genus Leishmania. Data on the features of LI in patients with inflammatory bowel disease (IBD) are scarce. Aim ...

Congratulations to @lmadero92 and @anaguticasbas for this excellent publication 👌🎯 @DHgua @geteccu @UEGJournal onlinelibrary.wiley.com/doi/10.1002/...

🤗 Felicitats a la Dra. Elisabet Tintó Font i a tot el grup de recerca 🔬 @CortesMalaria pel #PremisUB Ramon Margalef de la @ub.edu @rectorub.bsky.social Un exemple de recerca de qualitat i un model a seguir 🧑‍🎓👌
www.nature.com/articles/s41...

Frontiers | Unbiased immunome characterisation correlates with COVID-19 mRNA vaccine failure in immunocompromised adults

Happy to share the last manuscripts from our lab in spectral and computational cytometry in the blood and the human intestinal mucosa

www.nature.com/articles/s41...

www.frontiersin.org/journals/imm...