Carole Yauk

SCENARIOS will be at SETAC Europe 36th in Maastricht this May. Would you care to join us for more interesting results on our groundbreaking research results?

Check the info 👉https://www.setac.org/resource/what-to-line-up-for-setac-maastricht-before-registration-opens.html

🌟While celebrating 1100 LinkedIn followers we remind you of the recordings on YouTube and the scientific papers from 🌍 scenarios-project.eu

SCENARIOS at Horizon 2020 Green Deal Projects Newsletter: ec.europa.eu/newsroom/rtd...

Check out our sister projects
scenarios-project.eu/sister-proje...

⭐️SCENARIOS project's efforts ✅provided yet another 📑scientific article by Christos A. Aggelopoulos with the title: "Innovations in PFAS remediation: a review on the growing role of cold plasma technology"

Download it👉 scenarios-project.eu/download/inn...

📣Check tomorrow's event in North-West 📍Italy for PFAS strategies with experts, authorities and researchers.

You can follow it online🖥https://www.youtube.com/live/Qc2VbZIe4HQ

📣Tomorrow is the big event!

SCENARIOS workshop at REMTECHEXPO on 📆17th September in Ferrara 📍Italy; "PFAS Under the Lens: Science, Solutions and Society – H2020-SCENARIOS"

Join us also on Zoom us06web.zoom.us/w/8153777096...

More info and FREE registration👉 scenarios-project.eu

📣6 days to go!

for the upcoming SCENARIOS workshop at REMTECH to be held on 📆17th Sept in Ferrara 📍Italy; "PFAS Under the Lens: Science, Solutions and Society – H2020-SCENARIOS"

You can join us also on Zoom: us06web.zoom.us/w/8153777096...

More information and FREE registration👉 lnkd.in/dgTVNAWG

Dr. Evan Eichler is starting off day three of #EMGS2025 with his keynote lecture, "Telomere-to-Telomere Human Genomes and Germline Mutational Processes"!

Thank you to our #EMGS2025 Platinum Sponsor: Litron Laboratories. This meeting would not be possible without your support!

Thank you to our #EMGS2025 Platinum Sponsor: The Health and Environmental Sciences Institute. This meeting would not be possible without your support!

HESI's August 2025 Newsletter - Insights

🚨 The August Edition of HESI Global Insights is out now!
Read the full issue here: hesiglobal.org/hesi-insight...

Hertha Sponer in the lab. Credit: Science History Images/Alamy Stock Photo.

A substantial number of female physicists in the first half of the 20th century contributed to quantum physics. For the history of physics to properly recognize their work, new approaches are needed, argues Andrea Reichenberger in Nature Reviews Physics. go.nature.com/41mjQuJ #WomeninSTEM ⚛️ 🧪

🚀 Breakthrough in PFAS biomonitoring!

Using a clever ion pair extraction, the team detected total PFAS at 1 ppb in only a few minutes – no lengthy LC MS needed!

Read a short report on the action on👇
scenarios-project.eu/first-real%e...

📣Six days to go
Save the date!!📷We are organizing an open workshop on the 7th July at the Auditorium in FORTH/ICE-HT Conference Center in Patras, Greece📷📍

Contact Ms Kleanthi Zacharopoulou (kleanthi@iceht.forth.gr) to register for the workshop

Join us for a new #EMGS webinar, "The Art of Advocacy: Crafting Persuasive Letters," hosted by the Women in the EMGS SIG on June 25th!

Register Now: emgs-us.org/event/EMGSWE...

📣Save the date!!
We are organizing workshop for 7-8 July at the Auditorium in FORTH/ICE-HT Conference Center in Patras, Greece📍
Check it out on the images below👇
More information about the project and subscription for the newsletter 👉 scenarios-project.eu

📣Two days to go!
Join us in Alessandria📍or remotely via 👨‍💻https://teams.microsoft.com/l/meetup-join/19%3ameeting_YzZiZjhmNzQtMWNjNy00OWNiLTlhMTUtNWJmMzk1YmEzZTA4%40thread.v2/0?context=%7b%22Tid%22%3a%22492716f8-f2e3-4e38-a05f-af1787e9888d%22%2c%22Oid%22%3a%225d24d93a-192c-4177-a14b-a76d8c88756d%22%7d

Scenarios will be holding an open workshop with the title: "PFAS and the European Transition: Insights, Technologies, Strategies and Impacts from the SCENARIOS Project". The event will take place on 18 September 2025 in Ferrara, Italy, during RemTech.
Stay tuned for more info

📣Save the date
Interdisciplinary symposium “Interdisciplinary Symposium on One Health and PFAS – An Integrated Approach to Human, Animal, and Environmental Health”

📆 Date: June 20th
⏰ Time: 1:30 PM
📍 Venue: University Hospital of Alessandria
✅Format: In-person and online

More details to come soon!

Anybody else having trouble with the Convergence Portal today? My PDFs for my Transformation LOI won’t build no matter what I do. Wouldn’t on Friday either. Everything was fine on Thursday. #SSHRC @nserc-resnet.bsky.social

Submit a Late Breaking Abstract for #EMGS2025 by August 15, 2025! Don’t miss your chance to be a part of our program!

Submit an abstract today!
app.oxfordabstracts.com/stages/76738...

#EMGS #GenomicsConference #RochesterNY

CYP1A1/1A2 enzymes mediate glucose homeostasis and insulin secretion in mice in a sex-specific manner | American Journal of Physiology-Endocrinology and Metabolism | American Physiological Society The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that controls the expression of several downstream targets including xenobiotic metabolism enzymes, cytochrome P450 1A1 and 1A2 (Cyp1a1/1a2). Besides xenobiotic metabolism, AhR also mediates responses to other stressors including high-fat diets (HFDs). Although global deletion or downregulation of AhR protects against metabolic dysfunction in HFD-fed mice, the role of Cyp1a1/1a2 in glucose homeostasis remains unclear. We demonstrated that Cyp1a1 expression is induced in mouse pancreatic islets not only by xenobiotic exposure but also by HFD feeding. Since CYP1A1/1A2 enzymes can produce reactive oxygen intermediates, we hypothesized that chronic CYP1A1/1A2 activation may contribute to HFD-induced metabolic dysfunction in mice, and thus, deleting these enzymes may be protective. We fed 29- to 31-wk-old male and female global Cyp1a1/1a2 knockout (CypKO) and wild-type (CypWT) mice a 45% HFD or standard chow for 14 wk. CypKO females were partially protected from HFD-induced glucose intolerance, and chow-fed CypKO females had lower plasma insulin and suppressed insulin secretion in isolated islets compared with CypWT females. Meanwhile, CypKO males exhibited HFD-induced hyperinsulinemia later than CypWT males. HFD feeding elevated Cyp1a1 and other stress genes in CypWT male islets but not in CypKO islets, indicating that CYP1A1 mediates islet stress responses. Liver pathology, adiposity, and adipose inflammation were primarily affected by diet, not genotype, in both sexes. Our study highlights a novel sex-dependent role for Cyp1a1/1a2 in shaping the systemic metabolic response to HFD feeding, suggesting that CYP1A1/1A2 enzymes are involved in glucose homeostasis, insulin secretion, and islet stress responses. NEW & NOTEWORTHY Cytochrome P450 (CYP)1A1/1A2 enzymes have sex-specific roles in glucose homeostasis in mice. In females, global Cyp1a1/1a2 deletion partially protects from glucose intolerance in high-fat diet (HFD)-fed mice and lowers plasma insulin in chow-fed mice. In males, Cyp1a1/1a2 deletion delays HFD-induced hyperinsulinemia in vivo and inhibits HFD-induced islet stress responses. Genotype-driven differences were only seen in islets, suggesting a novel role for islet CYP1A1/1A2 enzymes in responding to metabolic stress.

I'm thrilled to share the latest paper out from our lab, led by an amazing PhD student, Angela Ching @angelaching.bsky.social! doi.org/10.1152/ajpe...

NIH employees publish ‘Bethesda Declaration’ in dissent of Trump administration policies | CNN Staffers at the US National Institutes of Health published a letter of dissent, taking issue with what they see as the politicization of research and destruction of scientific progress under the Trump...

Staffers at the US National Institutes of Health published a letter of dissent, taking issue with what they see as the politicization of research and destruction of scientific progress under the Trump administration. They called it the Bethesda Declaration, for the location of the NIH.

If you have not signed please do. If you have signed try to get several others to sign TONIGHT - NIH Director testifies before senate appropriations at 10am ET - lets make sure they know how many people are angry about what has been done to NIH

So much more to unpack in this article than the title conveys. I encourage all to read!

Students👥 from IES Peñas Negras de Mora visited our laboratory to observe the work carried out in the SCENARIOS project.

Check it out on👇
scenarios-project.eu/students-fro...

More information about the project and subscription for the newsletter 👉 scenarios-project.eu

MEET THE SPEAKERS! Our invited speakers for Symposium 9 of #EMGS2025 will include Drs. Ina Dobrinski and Brandon Pearson.🧬

Two more speakers will be selected from submitted abstracts for this session! 🔊

Submit an Abstract by May 31st: app.oxfordabstracts.com/stages/76738...

📢NEW YORK STUDENTS: We are offering a Free Student Day for local students at the #EMGS2025 Annual Meeting in Rochester! Come attend sessions, connect with peers, and explore career opportunities - FREE!

Just use the code STUDENT25DAY when you register!
emgs-us.org/page/2025-re...

Adverse Outcome Pathway-Informed Integrated Testing to Identify Chemicals Causing Genotoxicity Through Oxidative DNA Damage: Case Study on 4-Nitroquinoline 1-Oxide - PubMed Adverse outcome pathways (AOPs) provide a framework to organize and weigh evidence linking molecular interactions of toxicants in cells to adverse outcomes relevant to risk assessment or regulatory de...

AOP-informed, integrated NAMs for genotoxicity testing, featuring comet-chip and Duplex Sequencing. Powered by Elizabeth Huliganga and Eunnara Cho! Thanks to all collaborators and hope you’ll enjoy the ideas! Future looks bright 😎!

pubmed.ncbi.nlm.nih.gov/40341686/

There are 10 days left to apply for the #EMGS 2025 Samuel H. Wilson Award for Studies on DNA Repair! 🏆

Learn More and Apply by May 31st: emgs-us.org/page/sam-wil...

HESI's @hesiglobal.bsky.social Genetic Toxicology Technical Committee (GTTC) is seeking graduate students or postdoctoral fellows working in genetic-toxicology or genomics fields for the 2025 HESI GTTC Professional Development Award!

Learn More: connect.hesiglobal.org/3bqCXK