Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗

🦟 Transgenic parasites without Pfs230 D13D14 do not transmit

🦙 💉Nanobodies + mRNA induced antibodies reduce transmission

New in @Science.org

www.science.org/doi/10.1126/...

#ScienceResearch #Malaria #WEHI

01.08.2025 00:58 — 👍 62    🔁 17    💬 4    📌 2

Pfs48/45 nanobodies block Plasmodium falciparum transmission Malaria parasite fertilisation occurs within the Anopheles mosquito midgut. Interventions that inhibit parasite fertilisation prevent ongoing transmission and are important for malaria elimination eff...

Pfs48/45 nanobodies block transmission

🦟 Pfs48/45 Nb-Fc reduce oocyst numbers
💎 Structure of transmission-blocking Nb with Pfs48/45
👐🏽 Bispecific Nb-Fc targeting both Pfs230 and Pfs48/45
🧑🏻‍🔬 PhD student Frankie Lyons 1st Author 🥳

Please repost and happy reading!

www.biorxiv.org/content/10.1...

26.04.2025 23:58 — 👍 15    🔁 6    💬 1    📌 0

Stabilized designs of the malaria adhesin protein PvRBP2b for use as a potential diagnostic for Plasmodium vivax Plasmodium vivax is emerging as the most prevalent species causing malaria outside Africa. Most P. vivax infections are relapses due to the reactivation of the dormant liver stage parasites (hypnozoit...

Stabilized PvRBP2b variants - wonderful collab with Sarel Fleishman

🔥Increased yields and thermal stability

✌️Maintains human mAb recognition

🩸Sensitivity as a sero-diagnostic for P. vivax

💕 Editors Pick

👨🏻‍🔬First paper for PhD student Jaison

Please read & repost!

www.jbc.org/article/S002...

06.03.2025 04:51 — 👍 18    🔁 7    💬 0    📌 0

Stabilized designs of the malaria adhesin protein PvRBP2b for use as a potential diagnostic for Plasmodium vivax Plasmodium vivax is emerging as the most prevalent species causing malaria outside Africa. Most P. vivax infections are relapses due to the reactivation of the dormant liver stage parasites (hypnozoit...

Excited to share our latest work on stabilizing PvRBP2b, a key step toward P. vivax malaria diagnostics!
Huge thanks and congratulations to my incredible co-authors and collaborators! Honoured that this is my first PhD publication with @thamlab.bsky.social

www.jbc.org/article/S002...

06.03.2025 10:49 — 👍 0    🔁 0    💬 0    📌 0