Wai-Hong Tham

Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...

🎉 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐓𝐡𝐞 𝐄𝐌𝐁𝐎 𝐉𝐨𝐮𝐫𝐧𝐚𝐥!

After 8 months of revision, our work is now online: shorturl.at/WHmFq

We uncover a previously unrecognized way that 𝑀𝑦𝑐𝑜𝑏𝑎𝑐𝑡𝑒𝑟𝑖𝑢𝑚 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 survives toxic metal stress during infection.
...

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Generous international scolarships for our MSc in Epidemiology here in London. In memory of Bob May. My career is 100% resulting from something similar to this *cough* *cough* 25 *cough*.....years ago! www.imperial.ac.uk/study/fees-a...

Research Officer Job Title Research Officer Job Description An excellent opportunity is available for a Research Officer/Senior Research Officer to join the Callegari Lab in the Ubiquitin Signalling Division at Austra...

I'm hiring!
If you are a structural biology postdoc with strong cryo-EM experience who is excited about mitochondrial membrane complexes, please apply!

WEHI is a great place to work with access to state-of-the art cryo-EM facilities.

Apply here 👇 wehi.wd3.myworkdayjobs.com/broadbean_ex...

It's not too late to join us for Lorne I&I 2026! We have an incredible line-up of stellar Invited Speakers joining us from interstate and across the globe; check out our live Program for more details.
Don't miss out, register now! www.lorneinfectionimmunity.org/registration
#lorneiandi

The Biochemical Society 2025 Awards. International Award, Professor Renae Ryan, University of Sydney. Includes photo of Prof Ryan and Biochemical Society awards logo.

Internationally renowned as one of the leaders in neurotransmitter transport research, don't miss Professor Renae Ryan (@renaeryan.bsky.social) present her #BiochemSoc International Award Lecture at Membrane #Proteins Conference 2026! 🧪

Really happy to see this work out!

Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).

Been on multiple search committees

For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read

Controversial Danish vaccine research group faces new allegations Researchers say they couldn’t find complete data for 10 trials that together enrolled tens of thousands of children in Guinea-Bissau

Have I ever mentioned how surreal it is to be an Editor-in-Chief of a journal called Vaccine right now?

www.science.org/content/arti...

It’s pretty wild, at least by typical academic journal editorial office standards.

Alpseq: an open-source workflow to turbocharge nanobody discovery with high-throughput sequencing Nanobodies have emerged as promising tools for many biotechnological applications due to their small size, high stability and remarkable binding specificity. Next-Generation Sequencing (NGS) enable...

Alpseq - open source software to process and analyse NGS data for nanobody discovery 🦙 🧬

Led by Kathleen Zeglinski and @qgouil.bsky.social to provide a great solution to processing & analysing millions of nanobody reads from phage display campaigns to make the most of your sequence information!

The IMB at the University of Queensland is looking for a new Mass Spectrometry Facility Manager. See details below.
Closing date 13th of February.

uq.wd3.myworkdayjobs.com/en-GB/uqcare...

Thanks Geoff!

Beginning 2026 with a flipping good paper🚀 OSCA/TMEM63 proteins do double duty: they’re ion channels and mechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. 👏 @yiechanglin.bsky.social @charlesdcox.bsky.social doi.org/10.1038/s414...

Crystal structure of malaria parasite fusogen PfHAP2 domain 3 and nanobodies - unsolved mysteries galore! 🦟🦙💎

PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.

Check out the first crystal structure of PfHAP2 D3 and nanobodies

Pfs48/45 nanobodies block Plasmodium falciparum transmission Author summary Malaria is spread when an infected Anopheles mosquito bites a human. Within the female Anopheles mosquito, malaria parasite fertilisation occurs in the mosquito midgut. If you inhibit p...

Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎

Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕

Please share widely- love to hear your feedback!

Thrilled to share our latest work @luptoncj.bsky.social @drellisdon.bsky.social @drmlhalls.bsky.social.

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex.

🧪🔬#cryoEM
Now online @cellpress.bsky.social.

doi.org/10.1016/j.ce...

Our follow-up study on IgG4 in blood and saliva after 4 x COVID-19 mRNA vaccines is out on eBioMedicine 🧪

1)🧵So how does IgG4 influence responses to Omicron (XBB.1.5 and JN.1) and Sarbecoviruses (from bats, pangolins)? What epitopes are being targeted?

authors.elsevier.com/sd/article/S...

🎉Graduation Day! Congratulations to Dr Jaison D Sa @jaisondsa.bsky.social who was awarded his PhD from University of Melbourne

Wonderful to celebrate with his family, the lab and his co-supervisor Phillip Pymm 💕🎓 @wehi-research.bsky.social

Black text on white background under a square blue icon on the top left. Screenshot of tweet from the ARC saying they’ll announce outcomes of Centres of Excellence on Tuesday 9th Dec. 2025.

ARC says they’ll announce Centres of Excellence outcomes tomorrow (Tuesday 9th Dec).

This is more than 2 months late, most likely due to the new security checking requirements for ARC grants. Centres of Excellence grants also need to have been approved by the Minister.

MHH invites applications for a W1 university professorship for Systems Virology at CSSB. The research focus should be on analyzing viral infections using innovative, systemwide methods to elucidate virus-virus and virus-host interaction networks.

More info: t1p.de/nag2v

@bosse-lab.bsky.social

Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen Plasmodium falciparum HAP2 Malaria parasites are transmitted to humans through a bite from an infected female Anopheles mosquito. Within the mosquito midgut, malaria parasite gametes are activated and undergo fertilisation. If ...

HAP2 is an ancient fusogen and used by malaria parasites for gamete fusion during fertilisation 🦟

Please check out our preprint on Plasmodium falciparum HAP2 - crystal structure of domain 3 and nanobodies 🦙💎 still so much to discover about this fascinating protein 🥚

www.biorxiv.org/content/10.6...

ARC grant scheme timetable, including open, close and anticipated outcome announcement dates for Expressions Of Interest and full applications, plus rejoinder periods and selection meeting dates.

#ARCschedule Dec25

Outcomes expected … at some point, for Centres of Excellence – now 5 weeks late!

Other events:
🔹Close: Discovery Projects Expressions of Interest
🔹Take a damn break; you’ve more than earned it!

Data ▶️ docs.google.com/spreadsheets...

Mining and malaria in the Brazilian Amazon and in the Yanomami indigenous land Author summary The expansion of illegal mining in the Brazilian Amazon, and particularly in indigenous lands, has produced severely negative environmental and health externalities. One major health co...

"We estimate that a 1% increase in annual mining area was associated with a 24% increase in monthly malaria cases in the Yanomami. Also ... an estimated excess of 102,870 malaria cases occurred from 2018 to 2023 due to increased mining activity"
journals.plos.org/plosntds/art...

Join CSSB! The Sondermann lab is interested in deciphering the molecular processes that determine bacterial interactions in microbial communities. They are looking for a PhD candidate to investigate the bacterial secretion systems involved in these processes.

Apply now: v22.desy.de/e67416/recor...

Fun presenting our malaria work at Stromlo Plant Pathology - thanks @plantpathpete.bsky.social for the invite!

Megan Outram & Grace Jones gave lovely talks on our new work on chytrid fungus @biologyanu.bsky.social 🐸

Lovely to catch up with Barbara Howlett & learning about fungi 🍄‍🟫

#strompath25

Evidence of much wider distribution of the potential West Nile virus vector, Culex modestus, in the UK - Parasites & Vectors Culex modestus is a primary vector of West Nile virus (WNV) in Europe, feeding on both avian and mammalian hosts. Since its rediscovery in the UK in Kent in 2010, its range has been reported throughou...

Hello UK, West Nile Virus carrying mosquito Culex modestus is coming to a ditch near you! link.springer.com/article/10.1...

What a day at the Académie des Sciences! 🎉 Honored to receive the Allianz Prize / Institut de France. Huge shoutout to my dream team — none of this happens without you. 🙏🏽💥

@ugrenoblealpes.bsky.social
@inserm.fr
@cnrs.fr

Last week we had the CCeMMP Symposium 2025. Fantastic event with an outstanding line-up of speakers. There were 2 poster prizes and 1 oral presentation prize; thrilled that we did a clean sweep! Huge congratulations @tiltedscientist.bsky.social @somavallyd.bsky.social and @lucatroman.bsky.social

Excited to share matchbox. It’s super fast and versatile to search for patterns in reads, I’m curious to see all the uses it will find!
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...

Slide showing which countries have national research integrity offices

Speaker at the lectern

Next up: David Vaux with "An Office for Research Integrity in Australia – What are the barriers?"
* 23 European countries and 6 others have offices for research integrity.
* Australia has a guide with principles and responsibilities but institutions essentially investigate themselves.

#IRICSydney

Me too!