Danfeng Chen

Highlights
a) A distribution-free framework accounting for complex relationships among admixed populations.
b) Admixture-based estimation of individual-level pairwise coancestry at a resolution of kinship.
c) A tractable algorithm to form samples of genotypes from the estimated evolutionary process.

Identifying causal genotype-phenotype relationships for population-sampled parent-child trios The process by which genes are transmitted from parent to child provides a source of randomization preceding all other factors that may causally influence any particular child phenotype. Because of th...

Delighted to introduce our work on causal inference for genotype-phenotype analyses, with some thoughts about randomization in genetics www.biorxiv.org/content/10.1...

Coancestry superposed on admixed populations yields measures of relatedness at individual-level resolution The admixture model is widely applied to estimate and interpret population structure among individuals. Here we consider a "standard admixture" model that assumes the admixed populations are unrelated...

Happy to share "super admixture", a new framework for modeling the human population structure!
www.biorxiv.org/content/10.1...