Carolina Cigankova

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

📸 No one follows more etiquette rules than the Royal Family—but notice how King Charles didn’t make any smart-ass or demeaning comments about Zelensky’s attire today.

Why? Because respect isn’t about clothes—it’s about character. And that’s something money can’t buy.

Want to know what we do at our startup Deep Piction? Check out our paper with Denali Therapeutics. Using our proprietary clearing & imaging technologies, we mapped the full targeting profile of brain-penetrating transport vehicles (ATVs) in whole mouse bodies and monkey brains. go.nature.com/3Xifva2

Immune evasion of dormant disseminated tumor cells is due to their scarcity and can be overcome by T cell immunotherapies Dormant disseminated tumor cells (DTCs) persist despite anti-tumor immunity. How these cells evade immunosurveillance is unknown. Goddard et al. reveal a previously unappreciated form of immunoevasion called “relative scarcity” that underlies DTC persistence. T cell-based immunotherapies increase interaction frequency between DTCs and antigen-specific T cells, leading to DTC depletion.

2/ The relative scarcity of interactions between dormant disseminated tumor cells (DTC) and antigen specific T-cells explains immune evasion for metastasis! The authors reveal immune-strategies to overcome this for DTC eradication.

Cyrus Ghajar @fredhutch.bsky.social

www.cell.com/cancer-cell/...

We got a message from the university to remove any use of the "DEI", "diversity", "equity", or "inclusion" from all public-facing documents. They said that even "biodiversity" is being flagged by the federal government. We live in the dumbest timeline.

Deep visual multi-omics profiling reveals mechanisms that underly cancer cell differentiation and aggressiveness in clear cell renal cell carcinoma https://www.biorxiv.org/content/10.1101/2025.01.31.635927v1

Preventive cancer vaccines deliver tumor antigens or neoantigens, so that the immune system will attack tumor cells.

A new generation of cancer-preventing vaccines could wipe out tumors before they form.

Learn more on #WorldCancerDay: https://scim.ag/4gk8Qmo

Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors - Nature Nanotechnology In this study, the authors present optimization and efficacy testing of apolipoprotein-based lipid nanoparticles for delivering various nucleic acid therapeutics in vivo to immune cells and their prog...

New Paper Online:

Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors.

www.nature.com/articles/s41...

#Apolipoprotein #Nanotechnology #RNA

A human metabolic map of pharmacological perturbations reveals drug modes of action - Nature Biotechnology Mapping the metabolic effects of drugs helps define their mode of action.

A human metabolic map of pharmacological perturbations reveals drug modes of action - @zampierilab.bsky.social @depbiomedicine.bsky.social go.nature.com/3CreANg

See our recent @naturebiotech.bsky.social study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 www.nature.com/articles/s41...

Spatial-Mux-seq is a multimodal spatial platform for simultaneously profiling the transcriptome, chromatin accessibility, histone modifications, and select proteins.

www.nature.com/articles/s41...

Chinese firm’s faster, cheaper AI language model makes a splash DeepSeek’s open-source answer to ChatGPT is “a highly impressive display of research,” expert says

DeepSeek, a Chinese #AI firm and family of large language models, says it has found a way to match the performance of its U.S. rivals using second-tier graphics processing units—and at a fraction of the cost. scim.ag/4jqcFcF

#NieWiederIstJetzt

Some good news

Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex We find that the right and left auditory cortex in mice are both organised in cortical columns, with asymmetric myelination in the different layers and differences between the sexes. In addition, the...

As of today, the main finding of my PhD is published in the European Journal for Neuroscience! 🥳🥳

Together with Gesine Müller, we looked at hemispheric asymmetries in the mouse auditory cortex. We find layer, sex, and hemispheric differences: doi.org/10.1111/ejn....

🧵

Targeting FOXM1 condensates reduces breast tumour growth and metastasis - Nature The transcription factor FOXM1 forms functional condensates, the formation of which can be targeted with a specific peptide to suppress breast cancer growth and metastasis.

Nature research paper: Targeting FOXM1 condensates reduces breast tumour growth and metastasis

https://go.nature.com/4g7BNC8

Congrats!🎉🥳

Excited to share our new technique for visualizing nanoparticles or viruses at single-cell resolution across the entire mouse body! This approach uses deep learning for precise quantification, and we’ve made the code available-give it a try with your dataset! Thanks so much to the whole team!

Twitter:
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...

Unraveling the Phenotype of Dormant Metastases Controlled by the Immune System https://www.biorxiv.org/content/10.1101/2024.12.02.626440v1 During the progression of cancer, metastatic cells frequently enter a dormant phase. The immune syst

Unraveling the Phenotype of Dormant Metastases Controlled by the Immune System https://www.biorxiv.org/content/10.1101/2024.12.02.626440v1

SCP-Nano: A New Technology to Visualize Nanocarriers in Cells and Tissues

SCP-Nano: #PrecisionMedicine with Nanocarrier Visualization
Combining advanced imaging & AI, researchers at #HelmholtzMunich, LMU& TUM developed SCP-Nano, mapping nanocarriers in the body at single-cell resolution – offering more precise therapies.
👉https://t1p.de/muluc

The Real Reason People Don’t Trust in Science Has Nothing to Do with Scientists Propaganda works, is the real upshot of a survey showing lingering post-pandemic distrust of science

"propaganda by Trump’s allies to shift blame to scientists for his administration's disastrous handling of the COVID pandemic that killed 1.2M Americans..worked on some Republican voters" www.scientificamerican.com/article/the-...

My favorite proteomics papers of 2024! It's been...a...year....for sure.  And for proteomics, this is EASILY the biggest year ever. Mine kicked off with the honor of being invit...

Do you have a favorite proteomic paper of 2024? I narrowed my list down to 20-ish. (It's pretty clear what Nature had a favorite) proteomicsnews.blogspot.com/2024/12/my-f...

Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation | The EMBO Journal imageimageHypoxia contributes to cancer resistance to both standard therapies and immunotherapy. This work demonstrates that tumor hypoxia promotes immune evasion by autophagy-mediated downregulation ...

Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....

Were the cardiac metastases you found proliferative or non-proliferative? Thank you and happy New Year!

Aspartate signalling drives lung metastasis via alternative translation - Nature Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.

new out in Nature www.nature.com/articles/s41...

Transcriptional Dosage of Oncogenic KRAS Drives Lung Adenocarcinoma Cell States, Progression and Metastasis Cancer cells display distinct, recurrent phenotypic cell states. Metastatic spreading correlates with tumor cell state evolution. However, the molecular mechanisms underlying metastasis remain elusive...

In www.biorxiv.org/content/10.1... we propose that #KRAS #dosage integrates signaling & transcription to regulate cell states, driving #heterogeneity, progression & #metastasis

Proteomic Advances in Precision Oncology Mass spectrometry (MS) proteomics has emerged as a promising tool in the field of oncology through its comprehensive study of the biochemical processes underlying cancer.

Towards Precision Medicine:
www.labcompare.com/10-Featured-...

Quantitative Site-Specific Glycoproteomics Reveals Glyco-Signatures for Breast Cancer Diagnosis Intact glycopeptide characterization by mass spectrometry has proven to be a versatile tool for site-specific glycoproteomics analysis and biomarker screening. Here, we present a method using a new mo...

Quantitative Site-Specific Glycoproteomics Reveals Glyco-Signatures for Breast Cancer Diagnosis #AC pubs.acs.org/doi/10.1021/...

Telegram ‘rape chat groups’ with up to 70,000 members uncovered Users from multiple countries have been sharing tips on how to sedate and sexually assault women, German investigation finds

Words fail me

www.telegraph.co.uk/world-news/2...

youtu.be/GLrzyOLJUtk?...