Robert Jansen

The undiscovered natural product potential of Actinomycetes The Journal of Antibiotics - The undiscovered natural product potential of Actinomycetes

Recommended reading for those of us who study actinomycetes using untargeted metabolomics. Incredible work by @amcaraballor.bsky.social, @pieterdorrestein.bsky.social, and collaborators. rdcu.be/eSRxT

Ook Tweede Kamer wil dat álle stagiairs betaald krijgen: motie voor vergoedingen aangenomen - Vox magazine De Tweede Kamer vindt het niet eerlijk dat de ene student wel een stagevergoeding krijgt en de andere niet. Een meerderheid ging akkoord met een motie om de stagevergoeding voor alle studenten verplic...

De Tweede Kamer vindt het niet eerlijk dat de ene student wel een stagevergoeding krijgt en de andere niet. Een meerderheid ging akkoord met een motie om de stagevergoeding voor alle studenten verplicht te stellen.

Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome - Nature Communications Here, by integrating faecal metabolomics, metagenomics, and habitual dietary data of two large human cohorts, the authors show that faecal metabolites reflect diet and gut microbiome interactions, pre...

Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome.

By integrating faecal metabolomics, metagenomics, and dietary data Falchi et al. show that faecal metabolites capture mediations between diet and the gut microbiome

www.nature.com/articles/s41...

Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas - Nature Microbiology Targeting two distinct steps of the transcription process yields synergistic antibiotics that kill non-replicating Mycobacterium tuberculosis and reduce drug resistance.

Does this create an Achilles’ heel, and can you drug it? Turns out: yes.

Congrats to Barbara, Vanisha, Liz, and the rest of the team.

www.nature.com/articles/s41...

If you or someone you know is looking for a post-doctoral position working on mycobacterial envelope biology, please get in touch. I am recruiting here at the University of Western Ontario in London, Ontario, Canada.

I am very excited to announce that a fully funded PhD position is available in my group.

Topic: Synergistic coevolution in mono-specific and multi-species microbial consortia

Please RT or forward this information to interested candidates.

Deadline: 11.01.26

More info:

shorturl.at/f1TuF

Great work Daniel!

New paper from our team:
Led by @nike-wagner.bsky.social, we just published our findings on how the metabolite class of pteridines binds to the previously cryptic CutA protein. We used our native metabolomics approach to identify pteridines as ligands of CutA.
www.pnas.org/doi/10.1073/...

Semantic design of functional de novo genes from a genomic language model - Nature By learning a semantics of gene function based on genomic context, the genomic language model Evo autocompletes DNA prompts to generate novel genes encoding protein and RNA molecules with defined acti...

Phenomenal! WOOOOOOOW .... speechless
www.nature.com/articles/s41...

The limitations of small molecule and genetic screening in phenotypic drug discovery Phenotypic drug discovery is a powerful tool for uncovering new therapies, but small molecule and genetic screens each have distinct limitations. Vincent and Gianni analyze these challenges and suggest practical mitigation strategies to maximize screening success.

Online now! Online now! The limitations of small molecule and genetic screening in phenotypic drug discovery #chembiol

Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals.
A big leap in understanding TB’s survival tricks and new angles for therapies.

📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky

Systems analysis reveals alternate metabolic states adopted by Mycobacterium tuberculosis across species Mycobacterium tuberculosis (Mtb) persists within macrophages, yet how different host species shape bacterial state remains poorly understood. Here, we directly compared the intracellular transcriptome...

Excited to share our lab's newest preprint (strap in if you're excited about metabolism, species differences, or Mtb gene expression): www.biorxiv.org/content/10.1...

With the Wilmanns lab @embl.org we reveal cryoEM structures of an essential, bifunctional acyl-CoA carboxylase from mycobacteria. @wertheimufscripps.bsky.social

This ~ 600 kDa enzyme is asymmetric, rotatory, has unusual stoichiometry, and unique E5 subunits.

www.biorxiv.org/content/10.1...

Image of a patient in the x-ray laboratory in the background. Text reads 'Tuberculosis is the world's top infectious killer. TB caused 1.23 million deaths in 2024. Ending TB is possible. Fund it, research it, commit to it.'

#Tuberculosis (TB) is preventable and curable.

Yet, it remains one of the world’s deadliest infectious killers, claiming 1.23 million lives in 2024.

The WHO Global Tuberculosis Report 2025 talks about the gains made so far and the challenges ahead due to severe funding cuts: bit.ly/4qT5ihk

Want to find ways to combat TB? Check out this PhD position 👇

🚨 New Resource & Preprint Alert 🚨

This resource collected by the mFam consortiun led by Gerd Balcke and Steffen Neumann contributes >7000 mass spectra of 2,126 unique metabolites to the public domain through MassBank.
Preprint: lnkd.in/eYcJMqYn
Interactive plot: lnkd.in/egBaTTNH

#CompMetabolomics

VadK, a Non-Canonical Kinase that Regulates the Methylcitrate Cycle and is Essential for Mycobacterium tuberculosis Virulence The evolution of new enzymatic functions is constrained and guided by the architecture of an organisms metabolic and regulatory networks as well as by environmental constraints. Here, we identify a pr...

www.biorxiv.org/content/10.1...
Read it if you dare. Happy Halloween

Thermal Tracks: A Gaussian process-based framework for universal melting curve analysis enabling unconstrained hit identification in thermal proteome profiling experiments Thermal Tracks is a Python-based statistical framework for analyzing protein thermal stability data that overcomes key limitations of existing thermal proteome profiling (TPP) work-flows. Unlike stand...

For those who perform thermal proteome profiling (TPP) experiments, you might find this new data analysis approach (and open source Python software) useful. Developed by postdoc @jfhevler.bsky.social 🙏

arxiv.org/abs/2508.096...

#microsky #mevosky @spp2389.bsky.social

A PhD position is available in my lab to work on:

Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.

Please RT

Deadline: 12.11.25

More infos 👇
shorturl.at/rAKAT

Molecular Microbiology Group Information about research topics and publications about the group around Kirsten Jung

Pls share:
A postdoctoral research position is available in the group of Prof. Dr. Kirsten Jung at Ludwig-Maximilians-Universität München, Germany focusing on SRBs (www.bio.lmu.de/en/research/...)

Predicting functions of uncharacterized gene products from microbial communities - Nature Biotechnology FUGAsseM predicts protein function in microbiomes using coexpression patterns from metatranscriptomes and diverse community-wide data.

www.nature.com/articles/s41...

#microsky #microbiome

My fantastic department at CU Boulder is hiring a tenure-track Assistant Professor! This is a broad search spanning nearly all areas of biology. Applications are due Nov 13, 2025. Feel free to reach out to me with questions, and please share widely.
jobs.colorado.edu/jobs/JobDeta...

Ankündigung von offenen Stellen am Helmholtz-Zentrum für Infektionsforschung mit QR-Codes zu den Stellenanzeigen

We are looking for a new generation of scientists pushing the boundaries of infection research and using AI to shape the future of health research.
🚀Apply for junior group leader positions in our HUMAN program by November 26.
www.helmholtz-hzi.de/en/career/jo...
www.helmholtz-hzi.de/en/career/jo...

#microsky #mevosky @spp2389.bsky.social

A PhD position is available in my lab to work on:

Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.

Please RT

Deadline: 12.11.25

More infos 👇
shorturl.at/rAKAT

What a journey this book copy made! It was great meeting @elisabethbik.bsky.social in persoon again, and to hear her talk about science integrity issues at @isis-radboud.bsky.social this afternoon.

Photo of my right hand holding a book. It has a white cover with black letters: Stan van Pelt Sloppy Science Alles over wetenschapsfraude: van foutjes to nepcongressen And it features a blue abstract smear on the front

I will be bringing my copy of @stanvanpelt.bsky.social's new book Sloppy Science (in Dutch) to read in the train.

I hope he can sign it for me!

www.lebowskipublishers.nl/boek/3331/st...

Poster with QR code linking to the position

I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

Reposting, submit soon!