Fred Hutch Basic Sciences Division

RSV F evolution escapes some monoclonal antibodies but does not strongly erode neutralization by human polyclonal sera | Journal of Virology We describe an efficient approach to measure how antibodies inhibit infection by historical and recent human strains of respiratory syncytial virus (RSV). This approach is useful for understanding how...

Final version of this paper is published in Journal of Virology: journals.asm.org/doi/10.1128/...

If you are interested in implementing RSV pseudovirus neutralization assays, the plasmids are now available in AddGene (www.addgene.org/browse/artic...) and we are happy to share the 293T-TIM1 cells.

Virologist and HIV expert Dr. Michael Emerman retires During his 36-year career at Fred Hutch Cancer Center, Michael Emerman, PhD, made fundamental discoveries about HIV, the retrovirus that causes AIDS. He co-founded the field of paleovirology and consi...

During his 36-year career at Fred Hutch, @memerman.bsky.social made fundamental discoveries about HIV, co-founded the field of paleovirology and mentored generations of scientists. bit.ly/4nMqOmr @hutchbasicsci.bsky.social

"Signals, forces and cells: Force sensing in epithelial tissues"

We’re excited to have Dr. Jennifer Zallen joining us from @mskcancercenter.bsky.social for a special guest seminar. For all our @FredHutch.bsky.social colleagues, don’t miss a great talk today at noon!

Staff, faculty, providers and furry friends 🐶 came out to celebrate Fred Hutch's 50th Anniversary at the South Lake Union campus.
#fredhutch #fh50 #cancer #cancerresearch #cancertreatment #seattle

Scenes from the 51st @seattlepride.bsky.social!
#fredhutch

Zhiguo Zhang, PhD Institute for Cancer Genetics Professor of Epigenomics and Molecular Biology Department of Pediatrics Department of Genetics and Development Columbia University Irving Medical Center Title: “A Tale of Two Strands: Mechanistic Insights into Chromatin Replication Through Strand-Specific Sequencing” 12:00pm on Thursday, June 26, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch

For all our @FredHutch.bsky.social colleagues, don’t miss a special talk today at noon hosted by the Fred Hutch Chromatin Club. We’re excited to have Dr. Zhiguo Zhang joining us from @columbiamed.bsky.social to share his latest discoveries on chromatin replication.

Grateful to the lab for celebrating 25 years and to @hutchbasicsci.bsky.social for being such a great place to do science!

Fred Hutch joins the nation in commemorating Juneteenth National Independence Day, a time to honor the emancipation of enslaved African Americans in the United States. We celebrate the resilience and strength of those early Americans who never gave up hope during uncertain times.

Biggins Lab 25th anniversary celebration

Biggins Lab 25th anniversary celebration

Celebrating 25 years of curiosity, kinetochores, and cutting-edge science! Congratulations to the @suebiggins.bsky.social Lab @fredhutch.bsky.social on their 25th anniversary. Cheers to all the amazing colleagues that have made it such a wonderful place to do research over its past and present!

Congratulations to these exceptional early-career scientists!

Happy to present a single cell atlas of ALL glia, in BOTH sexes of an animal (in vivo validated!)! Fab work by postdoc @glia-maria.bsky.social, team, & collaboration with @manusetty.bsky.social . Find insights into glia, new analytics and ML models, and browse our companion website (wormglia.org)

From First Hill to South Lake Union, take a look at how the Fred Hutch campus has changed over the last 50 years. Learn more: www.fredhutch.org/en/news/cent...

Announcing The 2025 Rita Allen Foundation Scholars - Rita Allen Foundation Investing in transformative ideas in their earliest stages to promote breakthrough solutions to significant problems

Congratulations to @lapointelab.bsky.social‬ on being named a 2025 Rita Allen Foundation Scholar! This award will support his critical research @FredHutch.bsky.social studying how healthy cells control protein production and how this control breaks down in disease.

Basic Sciences Job Openings Job opportunities in the Basic Sciences Division at Fred Hutch.

We’re hiring two research administrators! Join us and help support the innovative and exciting research happening in the Basic Sciences Division @FredHutch.bsky.social.

Learn more and apply:

Happening TODAY - Manuel Rosero’s dissertation defense!
Title: Thermosensory Neurons Mediate Tactile-Dependent Locomotion Modulation in C. elegans
Lab: Bai Lab, FH
When: Friday, June 6, 2pm PDT
Where: FH Pelton Auditorium & Zoom (email mcb@uw.edu for link)

Basic Sciences Job Openings Job opportunities in the Basic Sciences Division at Fred Hutch.

Research administrators are crucial to our mission, helping support the innovative and exciting research happening in the Basic Sciences Division @FredHutch.bsky.social.

We’re hiring two research administrators and would love for you to join us:

My Keynote Talk at the CSHL 50th annual meeting on Retroviruses is now online:
leadingstrand.cshl.edu/Keynote/Medi... Some more general parts such as ~ the 8'30" mark with the "What I learned from Howard Temin" slide and ~ the 40' mark with the "What is important to me in science" section.

Announcing the 2025 Investigators in the Pathogenesis of Infectious Disease - Burroughs Wellcome Fund DURHAM, N.C. – The Burroughs Wellcome Fund proudly announces the 2025 Investigators in the Pathogenesis of Infectious Disease (PATH) award recipients. This year’s cohort represents a diverse group of…

🎉 Huge congratulations to Dr. Meghan Koch on being named a @bwfund.bsky.social‬ 2025 Investigator in the Pathogenesis of Infectious Disease! The award supports her groundbreaking research @FredHutch exploring how maternal-offspring interactions shape neonatal health.

Pleiotropic mutational effects on function and stability constrain the antigenic evolution of influenza hemagglutinin The evolution of human influenza virus hemagglutinin (HA) involves simultaneous selection to acquire antigenic mutations that escape population immunity while preserving protein function and stability...

In new study led by @timyu.bsky.social, we measure how mutations to H3 flu HA affect cell entry, stability & antibody escape

We find pleiotropic effects of mutations on these phenotypes shape evolution: epistasis alleviates cell-entry but not stability constraints

www.biorxiv.org/content/10.1...

Dr. Ruggero’s seminar is hosted by the Division of Basic Sciences. Davide Ruggero, PhD Professor Goldberg-Benioff Endowed Professorship Helen Diller Family Comprehensive Cancer Center Departments of Urology and Cellular & Molecular Pharmacology School of Medicine University of California, San Francisco Title: "Unfolding RNA structure for its translation in cancer & therapy” 12:00pm on Tuesday, May 20, 2025 Sze Combo (D1-080/084), Thomas Building, Fred Hutch

"Unfolding RNA structure for its translation in cancer & therapy”

We’re excited to have @ruggerolab.bsky.social joining us from @ucsfurology.bsky.social to speak at today’s Current Biology Seminar. For all our @FredHutch.bsky.social colleagues, don’t miss the final talk of the series!

Friday Afternoon Seminar (FAS), this Friday 5/16 at 4pm in Pelton. Rina Hirano, Tsukiyama Lab Elucidating 3D chromatin structure and its regulatory mechanism of rDNA in quiescence Christina Kuismi, Nabet Lab Targeted degradation of non-receptor tyrosine kinases PYK2 and FAK

Two great talks lined up for the final Friday Afternoon Seminars of the season!

For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.

Current Biology Seminar presented by Dr. Round, University of Utah. Dr. Round’s seminar is hosted by the Division of Basic Sciences. June Round, PhD Professor Department of Pathology University of Utah Title: "Microbiota-Immune interactions that promote health" 12:00pm on Tuesday, May 13, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch

"Microbiota-Immune interactions that promote health"

We’re excited to have Dr. June Round joining us from the University of Utah Department of Pathology to share her latest research at today’s Current Biology Seminar! For all our @FredHutch.bsky.social colleagues, don’t miss a great talk!

Friday Afternoon Seminars (FAS), this Friday 5/9 at 4pm in Pelton. Alex Kaiser, Stoddard Lab Bacterial islands of Defense: The BREX Antiviral Defense System Jae Heun Cheung, MacPherson Lab In vivo CRISPR activation screens identify potential drivers of chemoresistance in SCLC

We’re excited to have Alex Kaiser from the Stoddard Lab and Jae Heun Cheung from Human Biology’s @davidmacphersonlab.bsky.social sharing their latest research at Friday Afternoon Seminars. For everyone @FredHutch.bsky.social, don’t miss two fantastic talks today at 4:00!

Heterozygous and generalist MxA super-restrictors overcome breadth-specificity trade-offs in antiviral restriction Two evolutionary strategies allow the antiviral protein MxA to evolve simultaneous super-restriction against multiple viruses.

Really excited to share the final version of Rechel Geiger’s PhD thesis paper with help from friends

www.science.org/doi/10.1126/...

Rechel is now back in medical school training to become a kickass physician-scientist

Current Biology Seminar presented by Dr. Roy, University of Wisconsin-Madison. Dr. Roy’s seminar is hosted by the Division of Basic Sciences. Sushmita Roy, PhD Professor Department of Biostatistics and Medical Informatics Wisconsin Institute for Discovery University of Wisconsin-Madison Title: "Unsupervised learning for genomics to decipher dynamics of 3D genome organization and gene regulatory networks” 12:00pm on Tuesday, May 6, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch

"Unsupervised learning for genomics to decipher dynamics of 3D genome organization and gene regulatory networks”

We’re excited for a great talk from @sroyyors.bsky.social at today’s Current Biology Seminar! For all our @FredHutch.bsky.social colleagues, don’t miss it at noon in Pelton Auditorium.

Friday Afternoon Seminars (FAS), this Friday 5/2 at 4pm in Pelton. Rose Bosire, Adeyemi Lab LncRNA LAC mediates replication stress response via regulation of Exonuclease 1 Sarah Leichter, HenikoffLab Single-cell chromatin profiling of Polycomb repression identifies gene misregulation in the aging intestine

We have a Basic Sciences double feature at Friday Afternoon Seminars!

For all our @FredHutch.bsky.social colleagues, join us at 4:00 in Pelton to hear two great talks from Rose Bosire in the Adeyemi Lab and Sarah Leichter in the Henikoff Lab!

Current Biology Seminar presented by Dr. Dus, University of Michigan. Dr. Dus’s seminar is hosted by the Division of Basic Sciences. Monica Dus, PhD Director, Office of National Labs, The Office of the Vice President for Research Associate Professor, Department of Molecular, Cellular, and Developmental Biology University of Michigan Title: "Nutritional Inheritance in Development and Disease " 12:00pm on Tuesday, April 29, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch

"Nutritional Inheritance in Development and Disease"

We’re excited to have Dr. Monica Dus joining us from @umich.edu to share her latest research at today’s Current Biology Seminar! For all our @FredHutch.bsky.social colleagues, don’t miss a great talk at noon!

Friday Afternoon Seminars (FAS), this Friday 4/25 at 4pm in Pelton. Nick Salisbury, Galloway Lab Turning genes on and off: E2F/NF-κB controls the switch between Merkel cell polyomavirus replication and latency Erin Ramsey, Eisenman Lab mRNA m6A Modification: A Key for Stress Regulation in MYC-driven Pancreatic Cancer

Excited for two great speakers at Friday Afternoon Seminars!

For everyone @FredHutch.bsky.social, join us at 4:00 in Pelton to hear Erin Ramsey
from the Eisenman Lab and Nick Salisbury from Human Biology’s Galloway Lab share their latest research!

Managing mountains of genomic data The sheer volume of genomic sequences of SARS-CoV-2 — a dataset that is orders of magnitude bigger than what’s available for any other pathogen — has overwhelmed the capacity of common analytical meth...

Two recently published papers from postdocs in the labs of Drs. Trevor Bedford and @jbloomlab.bsky.social, showcase new tools that provide researchers traction to make the mountain of data amassed in studying SARS-CoV-2 and its many variants more manageable. 1/3 www.fredhutch.org/en/news/cent...

Basic Sciences admin members during a facilities tour

We want to thank the division’s research administrators for their immeasurable impact on Basic Sciences @FredHutch.bsky.social. From keeping labs supplied, managing funding, and resolving problems big and small, we’re grateful for what they do every day. #AdministrativeProfessionalsDay