Pallett Lab UCL

UKRI #FLF community please help us and spread the word about our @carersinstemm.bsky.social upcoming report launch events.

➡️ First stop The University of Edinburgh on 22nd October

Register here: forms.office.com/pages/respon...

#UKRIFLF #FutureLeadersFellows

A phot showing a pile of printed report with green cover page. The front title reads The Dual Demands of Academic Travel and Caregiving and shows a graphic of different caregiving situations as well as a wordcloud.

Oh hello there!!! The printed copies of our report have arrived - and I am the chosen Laura to lug them across the country!

So, come and join us in Edinburgh on the 22nd of October for our first @carersinstemm.bsky.social report launch and get your own copy!

forms.office.com/Pages/Respon...

From 2006. A younger and shell-shocked looking Catherine on a balcony holding a very tiny baby with the mountains of Vancouver in the background. The baby is so new, Catherine still has the pregnant bump.

Conventional wisdom says motherhood should wait for tenure as before you land a permanent post, #academia is just not that family friendly🙁

@carersinstemm.bsky.social are calling for change and to celebrate their new report, a Saturday🧵on parenting & academia! 1/9 👩‍🔬🧪🔭⚛️

ℹ️: carersinstemm.co.uk

Screenshot of the front page of the carers in STEMM survey report

We are pleased to announce the publication of our STEMM sector-wide survey

The report highlights our findings & suggests recommendations. Now available to download here carersinstemm.co.uk

Please share especially w/ institutions, funders & allies

@laurawolz.bsky.social @carterlj.bsky.social

Do we have any contacts at a Northern Ireland university? 🙏🧪

Optimization of the Blocking and Signal Preservation Protocol in High‐Parameter Flow Cytometry High quality input data is the key to successful interpretation of any scientific assay. In flow cytometry, fluorescently-conjugated antibodies allow us to simultaneously measure an incredible range ...

New #flowcytometery protocol drop from Oliver Burton.

This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.

currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

🎉 Hot off the press! Our new review on liver resident CD8+ T cells is here - exploring the dual nature of these cells either as protective "Jekyll" 😇 or pathogenic "Hyde” 😈

Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!

Review @natrevgastrohep.nature.com
@ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
www.nature.com/articles/s41...

SOOOOO excited to see this online IN REAL-LIFE!!

Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪

Poster detailing a series of events hosted by Carers in STEMM in Edinburgh (22nd October), Manchester (13th November) or London (9th December). Events will be hybrid. Poster includes a QR code for registration. Contact us for alternative registration processes. Poster also details the financial support available to facilitate the full attendance of carers in STEMM or interested, supportive allies

🚨We're going on tour!🚨
Join us for 1 of our "Report Launch" networking events: Edinburgh, Manchester, London, or the comfort of your own home!

We will present the 'Carers in STEMM' survey findings, host panel discussions w/ policy markers, EDI advocates & fellow parents/carers.

Spread the word!📣

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...

MASH: the nexus of metabolism, inflammation and fibrosis

This review by Gregory R Steinberg & colleagues is part of JCI’s ongoing series, Evolving Insights into MASLD and MASH Pathogenesis and Treatment with series editor @hepascott.bsky.social: buff.ly/BgLh6mn

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis - Nature A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes...

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

www.nature.com/articles/s41...

Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures A pro-fibrotic, mechanosensitive CTHRC1+ fibroblast population derived from creeping fat drives intestinal fibrosis in Crohn’s disease.

Now online! Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures

TREM2 macrophages are associated with enhanced response to PD-1 blockade in human hepatocellular carcinoma @miriammerad.bsky.social
www.biorxiv.org/content/10.1...

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...

This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social

Thread below...

🚨Job Offer🚨PhD Student Position
The @lshtm.bsky.social, in partnership with the @mpidr.bsky.social is opening an 18-month Research Assistant position, with the successful candidate embarking on a PhD program at LSHTM.
www.demogr.mpg.de/en/career_61...
@ezagheni.bsky.social #phd #jobs #demography

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social
academic.oup.com/jimmunol/adv...

Photo of a young Malaysian male, taken in front of some trees

AND.... some more good news from us, our recent BSc graduate from the lab - Keshav - will be returning in a few weeks as our newly appointed research tech.

WELCOME TO THE TEAM, WELCOME TO THE MADNESS! #TeamScience

A Human Single-cell Atlas Identifies OLR1+ Scar-associated Macrophages as a Therapeutic Target for Chronic Liver Disease Chronic liver disease (CLD) is a major global healthcare problem. Irrespective of cause, chronic damage to the liver results in fibrosis, which is associated with adverse clinical outcomes. Immune cel...

Fantastic to see this out 👏

ScRNAseq data from 77 patients as an atlas for all to use. Used to identify a new subpopulation of pro-inflammatory scar-associated macrophages which promote fibrosis from our friends in the Ramachandran lab. 🧪 #liversky #immunosky

www.biorxiv.org/content/10.1...

Huge congrats to our superstar MRes student who absolutely smashed her project this year, won the best presentation prize and will be off to adventures new very soon for her PhD.

Well done Jacky 👏

Group Leader Career Development Fellowships - Dunn School Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

Are you a postdoc interested in the mechanisms of disease?

Do you have a great record and an exciting vision?

Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.

Deadline 30th September...pass it on!

www.path.ox.ac.uk/work-with-us...

MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines
www.science.org/doi/10.1126/... @sciimmunology.bsky.social @aliamini419.bsky.social @thelucygarner.bsky.social @nprovine.bsky.social

MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines Memory T cells drive early reactogenic responses to mRNA boosters via MAIT/innate-like T cells, which are tempered by dosing interval.

MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines

#gdTcells

Cells need to sense nutrients so that they can adjust their metabolism and growth accordingly. A key node in cellular nutrient sensing is the protein complex GATOR2, for which binging of two nutrient-sensing proteins has been solved
www.nature.com/articles/d41...
www.nature.com/articles/s41...

Fantastic opportunity to go work for a dear friend of the lab @beckilee.bsky.social in Manchester!!! Spread the word 🧪

👶✈️ Balancing caregiving and academic travel?

Join Dr. Laura Pallett for "The Dual Demands of Academic Travel and Caregiving"

🗓️ Sept 25 | 🕒15:00 CEST
🔗https://tinyurl.com/yefis2025-ia2

Hosted by the Improving Academia group of yEFIS

Quantitative imaging of lipid transport in mammalian cells - Nature Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...

We will! 🍾