Pallett Lab UCL

Pre-Cancer Immunology The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.

🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals.
✅ Wet & dry lab
✅ September 2025 enrolment
✅ UK tuition fees only

www.ucl.ac.uk/medical-scie...

Fantastic immunology 101. Share widely 😊👏

This is fabulous!

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis

😎 biology but double whammy for cancer patients

www.nature.com/articles/s41...
🧪

TGFβ-mediated signals involving IL-4 and PD-1 enable CD8+ T cells to establish tissue-residence in skin
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@natimmunol.nature.com
www.nature.com/articles/s41...

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...

And that's why they got a London Overground line named after them.

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...

Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value

I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!

Picture of a smiling person holding up a copy of a book.

First copies of my book are here!! As a new faculty member, I realized that in addition to my research job, I also had a leadership job…and I wasn’t prepared for that.

This book is the guide I wish I’d had then, with the goal of helping others now.
 
jenheemstra.com/book

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

Out now in #NatureMetabolism 🧪

This study shows that, compared to plant-based fats, animal-based fats accelerate tumour growth and impair anti-tumour response to melanoma in obese mice.

Same calories, different outcomes!

From the lab of @lydialynch.bsky.social

doi.org/10.1038/s422...

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying circulating senoproteins co...

The human proteome and organ age clocks across the lifespan, a tour de force report @cellpress.bsky.social
www.cell.com/cell/abstrac...

#EMBObarrierTissues - ready to swim!! looking forward to hosting you all in Basel with @maurogaya.bsky.social in August

Floss-based vaccination targets the gingival sulcus for mucosal and systemic immunization - Nature Biomedical Engineering Floss-based vaccination exploits the leaky junctional epithelium of the gingival sulcus to deliver different types of vaccine, inducing robust mucosal and systemic immunity and providing protection ag...

Dental floss as a #vaccination strategy? This study shows that floss-based vaccination can deliver protein, inactivated virus, peptide-presenting immunogenic nanoparticles, mRNA & induces #immuneresponses protecting against infectious disease in mice ➡️ www.nature.com/articles/s41... #immunity

Biggest trial shows four-day work week cuts stress — and workers say it boosts performance Compressing five days of work into four can create stress, but the benefits outweigh the downsides, sprawling study shows.

Moving to a four-day work week without losing pay leaves employees happier, healthier and higher-performing

go.nature.com/4mc53ep

TGF-β and IL-12 conversely orchestrate formation of CD103+ CD8 tumor-resident memory T cells to regulate response to therapeutic cancer vaccine
www.cell.com/iscience/ful...

Preprint: Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans @profshanecrotty.bsky.social @hannahdstacey.bsky.social
www.biorxiv.org/content/10.1...

Multi-parameter spectral flow cytometry panel for immune phenotyping of murine B and T cell responses
www.biorxiv.org/content/10.1...

Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity Memory CD8+ T cells have differential cytotoxic capacities across human tissues.

Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity

www.science.org/doi/10.1126/...

Mitochondrial respiration is necessary for CD8+ T cell proliferation and cell fate @natimmunol.nature.com
www.nature.com/articles/s41...

IL-4 impairs the formation of skin-resident memory CD8+ T cells - Nature Immunology Bromley and colleagues show that IL-4 decreases the responsiveness of CD8+ T cells to TGFβ, resulting in impaired formation of CD8+ TRM cells.

How does a Th2 response affect the formation of CD8 tissue-resident T cells at barrier surfaces? Glad to see the Bromley lab cracked it! IL-4 limits the formation of skin CD103+ TRM... intriguing implications for long-term mucosal immunity when Th1/2 are mixed

Cd69 mRNA levels distinguish potent and dysfunctional activation among CD69+ CD8 T cells in tumors @sciimmunology.bsky.social @maxkrummel.bsky.social
www.science.org/doi/10.1126/...

Vote for your facourite topic for our 2026 LIG meeting

1️⃣ Immunology across the lifecourse
2️⃣ Immunology in a changing world
3️⃣ Signals & senses: external influences on imm.cells
4️⃣ Bench to bedside Immunology

📊 Show results

BSI LIG Immunology Meeting 2026 - Mentimeter Be heard, collaborate, and share ideas—make meetings and classes more engaging with real conversations.

Let us know what YOU would like the theme of our next annual meeting to be! 🗳️

Vote now using this link:
www.menti.com/alu97vcw5ezm...

#LIG25

Selective remodelling of the adipose niche in obesity and weight loss - Nature An atlas study of adipose tissue in people with obesity undergoing weight loss and their lean counterparts reveals that weight loss reduces cell senescence but cannot reverse all the metabolic problem...

Weight loss improves health but What happens to cells in the fat during weight loss? Intriguingly, immune cell numbers decrease but their activated states persist w chronic inflammatory potential. Beautiful work from neighbors @mrc-lms.bsky.social Will Scott et al www.nature.com/articles/s41...

And we're off! Welcome all to our annual meeting 'Diversity in Immunology' 🥳

We have an exciting day ahead 🤩

Let us know your favourite moments of the day by using our hashtag! 😊

#LIG25

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social

You’ll all be missed … but good luck, congrats and best wishes for the new adventures ahead 👏

Congrats Matt. Thoroughly well deserved and a great new adventure

Cell competition acts as a previously unidentified tissue-sparing mechanism, regulated by the availability of extracellular amino acids (sensing of L-proline) and integrated stress response
www.science.org/doi/10.1126/...