Pallett Lab UCL

Yes I’m reposting myself! Vote!!!

Less than 3 weeks until our final report launch event
9th Dec. (London) 10am

We will be welcoming a fantastic panel:
🌟Jo O'Leary (UKRI)
🌟Sara Mole (UCL)
🌟John Tregoning (Imperial)
🌟Katie Perry (Daphne Trust)
🌟Jennie Evans (BSI)
🌟Ilaria Meazzini (RSC)

Register here: www.carersinstemm.co.uk

Very insightful launch of @carersinstemm.bsky.social today at @manchester.ac.uk! Understanding the barriers associated with caring responsibilities is something I'm really passionate about and its amazing to see Carers in STEMM quantifying and advocating for carers in academia.

Whoop whoop!!!!!!

To hear more about the Carers in STEMM survey - the hidden barrier to parents and carers - there is still time to join us

Manchester: 13th November
London: 9th December
(Both hybrid)

Spread the word!

IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions @cp-immunity.bsky.social
www.cell.com/immunity/ful...

Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall @sciimmunology.bsky.social @thedohertyinst.bsky.social
www.science.org/doi/10.1126/...

You've got just a few days left to submit your proposal to join us as a new Group Leader

📅 Applications close 2nd November

Package includes:

🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship

Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.

Want to get a tough sample, like lung, looking like this? Read more!

www.biorxiv.org/content/10.1...

Home Lab to Life: Innovations in Melanoma is a UK conference in Manchester on cutting-edge melanoma research, translational science and advances in treatments.

Interested in melanoma research from lab to life?

Register to join a leading melanoma conference focusing on translational research & treatment advances in Manchester

When: 12-13 March 2026

sites.manchester.ac.uk/from-lab-to-...

Share widely 🧪

Lab mice can now have periods like humans
Studies of rodents with a menstrual on/off switch could help people with endometriosis and other disorders
www.science.org/content/arti... @science.org
@biorxivpreprint.bsky.social @karalmckinley.bsky.social
www.biorxiv.org/content/10.1...

I’ll start …!

Had the honour of taking my wee one at ~7 months to the @britsocimm.bsky.social congress in Liverpool. Co-carer in tow, complete with funding from a BSI Carers Grant (although partner not pictured) ❤️❤️

UKRI #FLF community please help us and spread the word about our @carersinstemm.bsky.social upcoming report launch events.

➡️ First stop The University of Edinburgh on 22nd October

Register here: forms.office.com/pages/respon...

#UKRIFLF #FutureLeadersFellows

A phot showing a pile of printed report with green cover page. The front title reads The Dual Demands of Academic Travel and Caregiving and shows a graphic of different caregiving situations as well as a wordcloud.

Oh hello there!!! The printed copies of our report have arrived - and I am the chosen Laura to lug them across the country!

So, come and join us in Edinburgh on the 22nd of October for our first @carersinstemm.bsky.social report launch and get your own copy!

forms.office.com/Pages/Respon...

From 2006. A younger and shell-shocked looking Catherine on a balcony holding a very tiny baby with the mountains of Vancouver in the background. The baby is so new, Catherine still has the pregnant bump.

Conventional wisdom says motherhood should wait for tenure as before you land a permanent post, #academia is just not that family friendly🙁

@carersinstemm.bsky.social are calling for change and to celebrate their new report, a Saturday🧵on parenting & academia! 1/9 👩‍🔬🧪🔭⚛️

ℹ️: carersinstemm.co.uk

Screenshot of the front page of the carers in STEMM survey report

We are pleased to announce the publication of our STEMM sector-wide survey

The report highlights our findings & suggests recommendations. Now available to download here carersinstemm.co.uk

Please share especially w/ institutions, funders & allies

@laurawolz.bsky.social @carterlj.bsky.social

Do we have any contacts at a Northern Ireland university? 🙏🧪

Optimization of the Blocking and Signal Preservation Protocol in High‐Parameter Flow Cytometry High quality input data is the key to successful interpretation of any scientific assay. In flow cytometry, fluorescently-conjugated antibodies allow us to simultaneously measure an incredible range ...

New #flowcytometery protocol drop from Oliver Burton.

This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.

currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

🎉 Hot off the press! Our new review on liver resident CD8+ T cells is here - exploring the dual nature of these cells either as protective "Jekyll" 😇 or pathogenic "Hyde” 😈

Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!

Review @natrevgastrohep.nature.com
@ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
www.nature.com/articles/s41...

SOOOOO excited to see this online IN REAL-LIFE!!

Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪

Poster detailing a series of events hosted by Carers in STEMM in Edinburgh (22nd October), Manchester (13th November) or London (9th December). Events will be hybrid. Poster includes a QR code for registration. Contact us for alternative registration processes. Poster also details the financial support available to facilitate the full attendance of carers in STEMM or interested, supportive allies

🚨We're going on tour!🚨
Join us for 1 of our "Report Launch" networking events: Edinburgh, Manchester, London, or the comfort of your own home!

We will present the 'Carers in STEMM' survey findings, host panel discussions w/ policy markers, EDI advocates & fellow parents/carers.

Spread the word!📣

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...

MASH: the nexus of metabolism, inflammation and fibrosis

This review by Gregory R Steinberg & colleagues is part of JCI’s ongoing series, Evolving Insights into MASLD and MASH Pathogenesis and Treatment with series editor @hepascott.bsky.social: buff.ly/BgLh6mn

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis - Nature A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes...

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

www.nature.com/articles/s41...

Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures A pro-fibrotic, mechanosensitive CTHRC1+ fibroblast population derived from creeping fat drives intestinal fibrosis in Crohn’s disease.

Now online! Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures

TREM2 macrophages are associated with enhanced response to PD-1 blockade in human hepatocellular carcinoma @miriammerad.bsky.social
www.biorxiv.org/content/10.1...

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...

This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social

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