Pallett Lab UCL

Yesterday we had the privilege of contributing to a RoundTable in Whitehall on "Women in Research" - the future, barriers & potential solutions to address many systemic issues. We're excited to see how these conversations continue @laurawolz.bsky.social @carterlj.bsky.social @pallettlab.bsky.social

Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux Human pancreatic cancer cells sense specific components of the ECM to fine-tune their autophagy flux levels, conferring the ability to coordinate proliferation, survival, and responsiveness to chemotherapy. Targeting ECM sensing may turn this ability into a therapeutic opportunity.

Now online! Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux

Postdoc alert in spatial biology!

Building upon our previous work with MSI cancers (e.g. de Vries et al, Nature, 2023), the Voest Group at the NKI is hiring a (fully funded) postdoctoral fellow with strong expertise in spatial cancer biology.

Learn more / apply here: www.nki.nl/careers-stud...

Thanks to @iansample.bsky.social at the Guardian for covering the devastating funding cuts that are being proposed for UK (astro)physics, and the dire impact these would have on young researchers. Will UKRI/STFC reconsider? Will the UKGov step in?🤞👩‍🔬🧪⚛️🔭

www.theguardian.com/science/2026...

UKRI funding changes ‘pushing junior researchers abroad’ - Research Professional News Disruptions to core funding streams raise fears for a “generation” of early career researchers

On the difficult situation of young UK researchers 🧪🔭

Thanks @fionamcintyre.bsky.social and @isaacbarbosa1.bsky.social for the interview & excellent article.

#stfc #ukri #saveSTFC @ukri.org

UKRI funding changes ‘pushing junior researchers abroad’ www.researchprofessionalnews.com/rr-news-uk-r...

The emergence of cooperative behaviors, norms, and strategies across five diverse societies Children’s cooperative behaviors and norms develop along distinct cultural pathways shaped by local norms.

No matter where they live, kids cooperate according to their community’s social norms by middle childhood.

Learn more in #ScienceAdvances: https://scim.ag/4r0Rxga

Single Cell Glucose Uptake Assays: A Cautionary Tale Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...

****2-NBDG does not measure glucose uptake****

Just your regular reminder of this fact 😁.

See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.

This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄

pmc.ncbi.nlm.nih.gov/articles/PMC...

B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells B cells transiently increase interleukin (IL)-2 receptor expression upon activation. Gauthier et al. examine the B cell-intrinsic role of IL-2 and define an IL-2-MAF axis that promotes the differentiation of CD25+ age-associated B cells toward a regulatory, IL-10-producing phenotype that is protective in neuroinflammation.

Online now: B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells

Biomedical and life science articles by female researchers spend longer under review Women are underrepresented in academia, especially in STEMM fields, at top institutions, and in senior positions. This study analyzes millions of biomedical and life science articles, revealing that f...

Cost of being female lead/corresponding author in biomedical sciences: "[T]he median amount of time spent under review is 7.4%–14.6% longer for female-authored articles than for male-authored articles" even in disciplines where women well-represented. #AcademicSky

journals.plos.org/plosbiology/...

Vaccines in Pregnancy, UK | Learn More About Vaccination Today Comprehensive guide to vaccines during pregnancy in the UK, including timing and locations for vaccination. Essential information for expectant parents and healthcare providers.

Vaccination against whooping cough, RSV and flu during pregnancy saves babies lives, but expectant parents are sometimes unsure.

How do I know it's safe? Will it protect my baby?

To answer these questions, we've created www.vaccinesinpregnancy.org

#ObGynSky #MedSky #ImmunoSky

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Don't miss out on your chance to attend "Fuelling the immune response IV: #UKimmunometabolismMeeting2026"

Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science

📆16-17th April

www.immunology.org/events/fuell...

Metabolomic profiling reveals the potential of fatty acids as regulators of exhausted CD8 T cells during chronic viral infection @katekazane.bsky.social @ucsdmedschool.bsky.social
www.pnas.org/doi/10.1073/...

Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and role in disease - Nature Immunology Here the authors show that persistent antigen stimulation drives the generation of CD8+ tissue-resident exhausted T cells with distinct developmental origins, function and therapeutic responsiveness w...

'The presence of CD8+ T cells coexpressing residency and exhaustion molecules in chronic diseases often correlate with clinical outcomes; however, the relationship between these cells and conventional tissue-resident memory (TRM) cells or exhausted CD8+ T (TEX) cells is unclear.'
#Immunology

The effect of shingles vaccination at different stages of the dementia disease course A natural experiment found that herpes zoster vaccination reduced the occurrence of mild cognitive impairment and deaths due to dementia, indicating that the vaccine may slow the progression of dement...

Taking advantage of a natural experiment, this follow-up by @pascalge.bsky.social of their earlier study in Nature on the beneficial effects of shingles vacination on dementia. Very cool stuff!

www.cell.com/cell/fulltex...

Get to turn up to work to see these faces every day #ExtendedMainiFamily

@cp-immunity.bsky.social preview @pgtimmune.bsky.social : Importance of CD8+ Trm cell-derived interferon-γ in epithelial reprogramming for barrier defense in humans
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...

Absolutely fantastic news Jan!!! 👏👏🥂🥂

Spaceflight alters the immune regulatory functions of neutrophil granulocytes on T lymphocytes @cp-iscience.bsky.social
www.cell.com/iscience/ful...

Great to see our recent hepatic TRM review as the inspiration behind the @natrevgastrohep.nature.com December issue cover!

#ScienceWin ❤️

PhD Projects 2026: QMUL Centre for Predictive in vitro Models The Centre for Predictive in vitro Models (CPM) represents multidisciplinary research focusing on the development and use of predictive in vitro models at Queen Mary University of London. This incorpo...

Interested in developing an asthma organ-on-a-chip model? Then your luck is in! As I have a funded PhD as part of the COaCT PhD programme www.cpm.qmul.ac.uk/cdt/projects...

Yes I’m reposting myself! Vote!!!

Less than 3 weeks until our final report launch event
9th Dec. (London) 10am

We will be welcoming a fantastic panel:
🌟Jo O'Leary (UKRI)
🌟Sara Mole (UCL)
🌟John Tregoning (Imperial)
🌟Katie Perry (Daphne Trust)
🌟Jennie Evans (BSI)
🌟Ilaria Meazzini (RSC)

Register here: www.carersinstemm.co.uk

Very insightful launch of @carersinstemm.bsky.social today at @manchester.ac.uk! Understanding the barriers associated with caring responsibilities is something I'm really passionate about and its amazing to see Carers in STEMM quantifying and advocating for carers in academia.

Whoop whoop!!!!!!

To hear more about the Carers in STEMM survey - the hidden barrier to parents and carers - there is still time to join us

Manchester: 13th November
London: 9th December
(Both hybrid)

Spread the word!

IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions @cp-immunity.bsky.social
www.cell.com/immunity/ful...

Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall @sciimmunology.bsky.social @thedohertyinst.bsky.social
www.science.org/doi/10.1126/...

You've got just a few days left to submit your proposal to join us as a new Group Leader

📅 Applications close 2nd November

Package includes:

🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship

Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.

Want to get a tough sample, like lung, looking like this? Read more!

www.biorxiv.org/content/10.1...