🫁 Just passing on what I thought was a very nice diagram from Med G for respiratory physical examination. Always nice to have some materials on-hand for learners. #medsky #IMsky
Jorge Castillo, MD, shares data on an all-oral, non-chemo, fixed-duration regimen for Waldenström macroglobulinemia using pirtobrutinib and venetoclax. The combination delivered rapid, profound and 100% overall responses with manageable side effects and high rate of deep responses. #ASH25
Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from @kellybolton.bsky.social lab! #ASH25
#ASH25 let’s goooooo
📚 This T-cell NHL diagnostic slide has been circulating and provides a nice framework
#medsky #hemesky #hemeonc #lymphoma #pathsky #hemepath #Tcells #cellmarkers #biology #hematology #medicine #pathology #oncology #oncsky #diagnostics #meded
Final CAPTIVATE Analysis Data Support Frontline Fixed-Duration Ibrutinib Plus Venetoclax in CLL/SLL
#CLL #Hematology
www.onclive.com/view/final-c...
All signed up for the 2025 ASH Annual Meeting. Looking forward to it! #hemesky #ASH25
🩸 ISTH DIC score (overt ≥ 5)
Plt <50=2; 50–100=1
PT >6s=2; 3–6s=1
Fibrinogen <1.0g/L=1
D-dimer: >3× ULN=3; 1–3× ULN=2; none=0
#hemesky #medsky #coag #benignheme
Join us on October 25 for a packed day of thrombosis education for healthcare professionals. Register today at thrombosiscanada.ca/2025Conference
Mosunetuzumab/Polatuzumab Vedotin Is an Effective Off-the-Shelf Combo in R/R MCL @mdanderson.bsky.social @societyofhemonc.bsky.social #SOHO2025 #lymsm #hematology
www.onclive.com/view/mosunet...
🩺 Differentiation Syndrome
- complication that can occur during treatment of APL w/ ATRA+ATO
Clinical:
⬆️ WBCs
⬆️ Fever
⬆️ edema/body weight/pulmonary infiltrates
Mgmt:
- high-dose steroids
- cytoreduction
- antipyretics / cxs / abx for FN
- diuresis
#hemesky #hemeonc #medsky #APL #APML #leukemia
Not hard to tell that I’m currently on thrombosis! Having a good experience with the team here at McMaster. #thrombosis #hemesky #hematology
"Updated definition and scoring of disseminated intravascular coagulation in 2025: communication from the ISTH SSC Subcommittee on Disseminated Intravascular Coagulation."
Publié en juillet dans J Thromb Haemost.
#MedSky #DIC
www.sciencedirect.com/science/arti...
🩸📖 NEJM 2003: CLOT trial - 676 patients w/ cancer-associated thrombosis (CAT) - Dalteparin vs warfarin.
Dalteparin dose: 200 IU/kg sc daily ×1/12 → 150 IU/kg daily ×5/12 (total 6 months).
Outcome: ↓ recurrent VTE; no ↑ major bleed in the group who received dalteparin.
#hemesky #thrombosis #medsky
🩸Cancer-associated Thrombosis Trials: LMWH more effective than VKAs
CANTHANOX 2002:
Enoxaparin vs VKA
CLOT 2003:
Dalteparin vs VKA
ONCENOX 2006:
Enoxaparin vs VKA
LITE 2006:
Tinzaparin vs VKA
CATCH 2015:
Tinzaparin vs VKA
#thrombosis #clinicalTrials #hemesky #medsky #IMsky #oncology #hemeonc
CARAVAGGIO 2020 (1,170 pts):
Apixaban vs dalteparin for cancer VTE. Recurrent VTE 5.6 % vs 7.9 % (non-inf). Major bleed 3.8 % vs 4.0 %; no extra GI bleed. Bottom line: apixaban noninferior to dalteparin without increase in major bleeding in cancer-associated VTE. #medsky #hemesky #thrombosis
Lesson from this past week:
Isolated elevation of anticardiolipin IgM does not meet laboratory criteria for antiphospholipid syndrome! According to EULAR 2023 guidelines below. #medsky #IMsky #rheumsky #hemesky #antiphospholipid #thrombosis
Ven is effective (91% ORR) and well tolerated in octogenarians, but 43% hd treatment holds and 32% prolonged ramp-up. buff.ly/lNgBN1r #hemesky
Monoclonal Gammopathy: Paraneoplastic Neuropathy 🧠🩸
AL Amyloidosis: painful + length-dependent + sensory > motor
POEMS: symmetric disabling demyelinating polyneuropathy
DADS-M: distal loss of proprioception + demyelinating + coarse tremor + mild motor weakness
#hemesky #myeloma #medsky #neurosky
Chronic myeloid leukemia is a myeloproliferative neoplasm.
This Review summarizes the epidemiology, diagnosis, and management of chronic myeloid leukemia.
https://ja.ma/4mlR6ez
Thanks for the added detail! 🔬
Unveiling the enigma: circulating flowerlike large B-lymphoma cells in the context of angioimmunoblastic T-cell lymphoma
buff.ly/bbBzTQG #hemesky #lymphoidneoplasia
🔬🩸Hemoglobin development (some fundamentals!)
Embryo
Hb Gower I = ζ2ε2
Hb Gower II = α2ε2
Hb Portland = ζ2γ2
Fetus
HbF = α2γ2
Adult
HbA = α2β2 ~97%
HbA2 = α2δ2 ~2–3%
HbF <1%
#hemesky #medsky #IMsky #benignheme #hemoglobin #pediatrics
JAK Inhibitor–Based Combos and Mutation-Specific Regimens Comprise the Future of Myelofibrosis Management
#MPNsm #hematology #oncology
www.onclive.com/view/jak-inh...
Workin. CML in a 27 Year old. #haematology #hematology
💊 Abatacept
Humanized protein construct from recombinant DNA (CTLA4 + IgG1 Fc) grown in hamster ovary cells.
Selectively binds to CD80/86 on APCs, inhibiting CD80/86-CD28 costimulatory signal essential for full T-cell activation.
#medsky #IMsky #rheumsky #biologics
(Herrero-Beaumont et al., 2012)
Isatuximab Plus VRd Wins EU Approval for Newly Diagnosed, Transplant-Ineligible Multiple Myeloma
#mmsm #Hematology
www.onclive.com/view/isatuxi...
This recently published study highlights the prognostic significance of high-risk cytogenetic abnormalities in multiple myeloma. Genetic alterations like t(4;14), del(17p), and +1q are linked to poorer prognosis and shorter survival #MM #hematology 👉https://bit.ly/3PzY1BT
This looks awesome! 🔬🤩
Congratulations to you! Wishing you good health going forward ♥️
