Rob Waterhouse

Rob Waterhouse

@rmwaterhouse.bsky.social

Director, Environmental Bioinformatics Group at SIB Swiss Institute of Bioinformatics @sib.swiss. Chair, European Reference Genome Atlas (ERGA, @ergabiodiv.bsky.social). #biodiversity #genomics www.rmwaterhouse.org

2,198 Followers 1,803 Following 1,802 Posts Joined Nov 2024
1 week ago
A phylogenetic tree of insects is shown annotating the presence or absence of a an antimicrobial peptide gene across winged insects Various phylogenetic secondary loss events are mapped to a tree of insects to explain the parsimony calculations necessary to explain the diversity of insect Drosomycin antimicrobial peptide genes Antimicrobial peptides (AMPs) are key defence molecules of the innate immune system of plants and animals. Understanding the evolutionary origins of AMPs can help to explain how immune systems acquire novelty and vary in their defensive capabilities. However, AMPs evolve rapidly, and so the origins of similar AMPs across organisms is often unclear. Furthermore, false negatives due to low search sensitivity are common and can hinder confident annotations about true absences. Due to these difficulties, understanding whether similar AMP genes found in diverse organisms represent ancestral molecules or evolutionary novelties has been challenging. In this report, we present evidence of
horizontal gene transfer (HGT) of the antifungal peptide gene Drosomycin across insects. We show that in Diptera, the presence of Drosomycin is restricted to the Melanogaster group and additionally the
distant relative Drosophila busckii. We go on to recover Drosomycin genes in cockroaches (Blattodea), mantises (Mantodea), one katydid (Orthoptera), various beetles (Coleoptera), and a recently acquired
pseudogenized Drosomycin locus in Liposcelis booklice (Psocodea), but no other insects. Explaining this diversity through shared ancestry requires at least 50 independent loss events, or just seven HGT
events. Previous studies have suggested that similar AMPs found across divergent species reflect conservation from a common ancestor, or due to their small size, that they arose via convergent evolution resulting from pathogen-imposed selection. Our findings suggest horizontal gene transfer can be responsible for the presence of some AMP genes found scattered across the tree of life. By presenting a mechanism through which immune systems can acquire novelty, our study also suggests a possible explanation for certain lineage-specific competencies for defence against infectious disease. While loss of AMP genes is common in certain lineages, here we suggest gain of AMPs can occur just as suddenly.

Pleased to finally share this fun collab that began at #Ento23

@cedricaumont.bsky.social presented & I had seen NCBI annotated some cockroach genomes as "contaminated." Turns out NCBI & I were wrong (much more fun).

Horizontal transfer of an #AntimicrobialPeptide across insects
bit.ly/DrsHGT

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Biodiversity Data Unlocked: Publishing in GBIF with IPT A certain number of places will be attributed in priority to CUSO members. Overview This course will introduce participants to the process of publishi

๐ŸŸข Are you a researcher in #Switzerland involved in collecting species observations #data ? ๐Ÿ—บ๏ธ๐Ÿฆ‹๐Ÿธ๐Ÿฆ‰
๐ŸŸฃ Then you can join us to learn about Swiss #biodiversity data mobilisation, publication, & sharing !
www.sib.swiss/training/cou...

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#biodiversity #bioinformatics Summer School ... 21-26 June in Siegen, Germany co-organised by @sib.swiss & @denbi.bsky.social
www.sib.swiss/training/cou...
๐ŸŸข eDNA & ecosystems
๐ŸŸฃ pangenome diversity
๐Ÿ”ต population genetics
๐ŸŸก comparative genomics
Register to apply, selections will start from March 16th

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๐Ÿ†• The @biogeneurope.bsky.social project - which now gives way to BGE+ - represented a landmark in European research collaboration, bringing together the #DNAbarcoding (@iboleurope.bsky.social) and #reference #genomes (@ergabiodiv.bsky.social) communities.

๐Ÿ”“ Grant Proposal: doi.org/10.3897/rio.....

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Vector venom: venomics of Aedes albopictus reveals a large enzyme repertoire and novel cecropins with activity against E. coli - npj Drug Discovery npj Drug Discovery - Vector venom: venomics of Aedes albopictus reveals a large enzyme repertoire and novel cecropins with activity against E. coli

It's great to see our next vemomics paper out there! This time, our PhD student Ludwig milked hundreds of mosquitoes and examined their venom (yes, he milked them!). Check out how he did it and what we found in their venom. Great work! ๐ŸฆŸโ˜ ๏ธ๐Ÿ‘ www.nature.com/articles/s44...

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Call for Applications: Doctoral Positions in the Life Sciences and Natural Sciences Ambitious candidates with a strong academic track recordย who wish to pursue their doctorate in one of the research areas listed below.

๐Ÿ“ฃ Call for Applications: The University of Vienna invites applications for more than 40 fully funded doctoral positions across a broad range of disciplines in Life Sciences and Natural Sciences. ๐Ÿ‘จโ€๐Ÿ”ฌ๐Ÿ‘ฉโ€๐Ÿ”ฌ #PhDSky #PhD #univie
๐Ÿ“… Application period: 2 March โ€“ 27 March 2026, 12:00 CET

More information: โคต๏ธ

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EBP-affiliated projects worldwide are pushing the limits of whatโ€™s possible โ€” driving innovation and the breakthroughs that make this moonshot real.
Global community = global progress ๐ŸŒ๐Ÿงฌ

@vertebrategenomes.bsky.social
@ergabiodiv.bsky.social
@catbiogenoma.bsky.social
@biogeneurope.bsky.social

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Training Modules - Threatened Species Initiative Welcome to the Threatened Species Initiative (TSI) open online course: Conservation Genomics for Threatened Species Management. The training modules are presented by a range of Australianโ€ฆ

๐Ÿ’ก #KnowledgeHighlight | Conservation #Genomics for Threatened Species Management @ausbiocommons.bsky.social ๐Ÿจ threatenedspeciesinitiative.com/training-mod...
Explore open-access training materials in the ERGA #KnowledgeHub โžก๏ธ knowledge.erga-biodiversity.eu @bioplatformsaus.bsky.social #conservation

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MBE | The role of society journals in protecting the scientific record

MBE Editors-in-Chief Claudia Russo and Brandon Gaut publish a new editorial on the role of society journals in protecting the scientific record.

๐Ÿ”— doi.org/10.1093/molbev/msag022

#evobio #molbio #societyjournal

@claurusso.bsky.social @bsgaut.bsky.social

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Pangenomes, really?

Most early โ€œpangenomesโ€ = oligogenomes (oligo, Gr., few).

More recent โ€œpangenomesโ€ generally = poligenomes (polis, Gr., many).

True pangenomes (pas, Gr., every/all) would be rare indeed.

๐Ÿ™๐Ÿผ @zbao.bsky.social for pointing out his review.

www.nature.com/articles/s41...

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3 weeks ago

Finally published! We first uploaded this preprint in 2022 but dropped it after frustrating reviews.
It was well received and cited, motivating us to revisit it.
We added new content, including simulations and a proof-of-concept genomic green status assessment.
#consgen #popgen #PopulationGenomics

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Quote by Luthando Dziba: This yearโ€™s World Wildlife Day theme, โ€œMedicinal and Aromatic Plants: Conserving Health, Heritage and Livelihoodsโ€, focuses attention on the vital contributions that plants make to human wellbeing, and the roles they play in culture as well as the global economy. But with a million species of plants and animals currently threatened by extinction, medicinal and aromatic plants โ€” including plants which have not yet been described by science โ€” are also in jeopardy.

On this #WorldWildlifeDay, we can recommit to action that recognizes natureโ€™s values in all their forms โ€” as a source of medicine and culture, pillars of healthy ecosystems, and foundations of resilient communities. ๐ŸŒ

๐Ÿงช Read more from ๐Ÿก IPBES ES, Luthando Dziba: https://www.ipbes.net/node/97615

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Discover the new SIB learning paths ๐Ÿงฌ Structured #Bioinformatics training from beginner to advanced levels, including machine learning and omics data analysis. Plan your next learning step and share within your network

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Convergent evolution of hexenal isomerases in Lepidoptera and plants - Nature Ecology & Evolution Phylogenetic and functional analyses across 34 Lepidoptera and 183 plant species show that hexenal isomerases found in Lepidoptera exhibit functional convergence with those found in plants despite hav...

Phylogenetic and functional analyses across 34 Lepidoptera and 183 plant species show that hexenal isomerases found in Lepidoptera exhibit functional convergence with those found in plants despite having evolved independently from unrelated enzyme families ๐Ÿงช www.nature.com/articles/s41...

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We can help protect insect biodiversity by:
๐Ÿž Expanding research
๐Ÿœ Monitoring insects & related species across landscapes
๐Ÿชฐ Promoting improved pest management techniques
๐Ÿฆ— Protecting & restoring habitat
๐Ÿ Facilitating collaboration between entomologists, other scientists, policymakers & citizens

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The image is a collage of five insect photos (an oak treehopper, desert ironclad beetle, red-blue checkered beetle, blue morpho, and dragonfly). In the center, there is white text on a blue background that says, โ€œโ€œThe little things that run the world.โ€ -E.O. Wilson.โ€ There is also the hashtag #WorldWildlifeDay and the ESA logo.

Today, March 3, is #WorldWildlifeDay! More than half of all species on Earth are insects and their relativesโ€”or in the words of conservationist E.O. Wilson, "the little things that run the world."

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A sedge. It may look unassuming but its genome has several unusual features.

Why do the chromosomes of cyperids (sedges & rushes) split and fuse so regularly on evolutionary timescales?

Is it because they have so many centromeres?

Our new preprint, the first major paper of my PhD, addresses this question. ๐Ÿงตโฌ‡๏ธ 1/12

www.biorxiv.org/content/10.6...

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#biodiversity #bioinformatics Summer School ... 21-26 June in Siegen, Germany co-organised by @sib.swiss & @denbi.bsky.social
www.sib.swiss/training/cou...
๐ŸŸข eDNA & ecosystems
๐ŸŸฃ pangenome diversity
๐Ÿ”ต population genetics
๐ŸŸก comparative genomics
Register to apply, selections will start from March 16th

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1 week ago

#biodiversity #bioinformatics Summer School ... 21-26 June in Siegen, Germany co-organised by @sib.swiss & @denbi.bsky.social
www.sib.swiss/training/cou...
๐ŸŸข eDNA & ecosystems
๐ŸŸฃ pangenome diversity
๐Ÿ”ต population genetics
๐ŸŸก comparative genomics
Register to apply, selections will start from March 16th

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Actions and actors driving transformative change for global sustainability - Nature Sustainability A bibliometric analysis of more than fourโ€‰million scholarly documents highlights the need for a more inclusive approach to research on actors and actions needed for transformative change towards a jus...

Drawing on work from the @ipbes.net ๐“๐ซ๐š๐ง๐ฌ๐Ÿ๐จ๐ซ๐ฆ๐š๐ญ๐ข๐ฏ๐ž ๐‚๐ก๐š๐ง๐ ๐ž ๐€๐ฌ๐ฌ๐ž๐ฌ๐ฌ๐ฆ๐ž๐ง๐ญ & bibliometric analysis of >4โ€‰million scholarly documents - a more inclusive approach needed to research on actors and actions www.nature.com/articles/s41...

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One million of the worldโ€™s estimated 8 million species are threatened with extinction.

But hope is not lost.

#GenerationRestoration is reviving habitats bringing back homes for threatened species.

This #WorldWildlifeDay, discover six species making a comeback: www.unep.org/news-and-sto...

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Biodiversity Genomics Europe (BGE) Project โ€“ Abridged Grant Proposal The Biodiversity Genomics Europe (BGE) Project has the overarching aim of accelerating the use of genomic science to enhance understanding of biodiversity, monitor biodiversity change, and guide inter...

The #Biodiversity #Genomics #Europe project comprised activities focused on #DNA Barcoding (Barcoding Stream) and Reference #Genome Generation (Genomes Stream) for eukaryotic species across Europe riojournal.com/article/1875...

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Annotating genomes at increased scale and resolution - Nature Reviews Genetics In this Review, Ji et al. overview how rapidly advancing experimental and computational methods are enabling improved and automated annotation of gene structure and function, providing researchers wit...

The growing number of sequenced #genomes provides a positive feedback loop, in which database searches become more effective and shared sequence patterns emerge more clearly www.nature.com/articles/s41... #biodiversity #genomics

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Be part of the global biodiversity genomics community ๐ŸŒ๐Ÿงฌ๐Ÿš€

Join the conversation by referencing biodiversity genomics or ๐ŸŒ๐Ÿงฌ

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Limitations of molecular dating using constant birthโ€“death rate priors in deep time reflected in Brachiopoda evolution Molecular dating often struggles to align with fossil records when divergence times are estimated in deep evolutionary history, particularly during thโ€ฆ

Limitations of molecular dating using constant birth-death rate priors in deep time reflected in Brachiopoda evolution www.sciencedirect.com/science/arti...

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Huge news ๐ŸŒ๐Ÿงฌ
The Protist 10,000 Genomes Project is joining the Earth BioGenome Project.
Protists may represent the majority of eukaryotic diversity โ€” yet only a tiny fraction have reference genomes.
Time to change that. ๐Ÿš€โœจ
Learn more ๐Ÿ‘‰ ngdc.cncb.ac.cn/p10k/
#EBP #Protists #Genomics #TreeOfLife

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The biodiversity, genomics, ecology and evolution of mushroom-forming fungi - Nature Reviews Biodiversity Mushroom-forming fungi have along evolutionary history and a suite of important ecological roles. This Review highlights advances in understanding of Agaricomycetes evolution and ecology driven by gen...

Everything you always wanted to know about mushroom-forming fungi! Great collab with amazing mycologists. Thanks Laszlo Nagy for leading this effort!

www.nature.com/articles/s44...

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New #OpenAccess research by M. Prous, @niinakiljunen.bsky.social et al. in #RESSystematicEnt found that multiple full-length variants of the mitochondrial COI DNA barcode region are prevalent in north European sawflies.
doi.org/10.1111/syen.70031

@gkergoat.bsky.social @wileyecology.bsky.social

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Evolution, genomicsย and conservation of butterflies and moths - Nature Reviews Biodiversity Butterflies and moths are key indicators of functioning and healthy ecosystems around the world. This Review describes the evolutionary history of the order Lepidoptera and tracks shifts in researcher...

Evolution, genomics and conservation of butterflies and moths
www.nature.com/articles/s44...

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European red list of bees - Publications Office of the EU

European Red List of Bees
op.europa.eu/en/publicati...

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