Check out 🧐 our new preprint 📜:
www.biorxiv.org/content/10.1...
Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠
#microsky #teamtomo #Chloroflexota

#MicroSky: Flu season? Fast, simple & accurate tests are vital. Fan et al developed a tech that detects influenza A & B genes plus controls in just 35 min, matching PCR accuracy. It seems easy to use, works in low-resource settings, and could transform flu diagnosis worldwide doi.org/10.1111/1751...

#MicroSky: Wu et al discovered AMM-1, a novel metallo-β-lactamase (MBL) from Alteromonas, that confers broad β-lactam & carbapenem resistance, shares features with clinical MBLs, & points to hidden environmental reservoirs. Urgent need for Antibiotic Resistance surveillance! doi.org/10.1111/1751...

#MicroSky: Longhi et al analyzed the upp gene, key for pyrimidine salvage, across 107 Bifidobacteria. Its unique evolution vs. 16S rRNA hints at adaptation to low-uracil environments, possibly giving bifidobacteria an edge in nutrient-limited human guts. doi.org/10.1111/1751...

#MicroSky: Active transposable elements destabilise Shewanella oneidensis genomes under stress, often hitting megaplasmids. Blocking these with CRISPR/dCas9 cuts transposition, paving the way for more stable strains in industry. Read Fritz et al in Micro Biotech. doi.org/10.1111/1751...

#MicroSky: Thanks to a dampened inflammatory innate immune response, various bat species frequently carry diverse viruses that can cause severe diseases in humans. The reasons why bats are a pivotal virus reservoir for emerging viral diseases are discussed by Brüssow in MBT. doi.org/10.1111/1751...

#MicroSky: Microbial biotechnologies impact health in many ways—via food, nutrition & our environments. Yet health impact assessments (HIAs) are rarely used. Routine HIAs can help maximise benefits, avoid risks & cut health inequalities. doi.org/10.1111/1751...

#MicroSky: Stable microbial bioproduction is key for green biomanufacturing, but genetic heterogeneity limits scale-up. In B. subtilis, Cao et al developed SiteMuB & ChassisLMR to reduce mutations & boost stability. They raised titers up to 16×. doi.org/10.1111/1751...

#MicroSky: Enhanced PhzO hydroxylase activity in P. chlororaphis by expressing Flavin reductase. Boosted biocatalysis & produce new 3,4-dihydroxy-PCA. PhzO showed FAD-dependent promiscuity, making 2-OH & 3,4-OH phenazines, with product ratios based on substrate levels. doi.org/10.1111/1751...

#MicroSky: High-traffic spaces can boost infection spread, while chemical disinfectants may fuel drug resistance. Probiotic-based cleaning offers a novel, eco-friendly way to control bioburden and prevent infections. Read the OPINION of Soffritti et al in MBT. doi.org/10.1111/1751...

#MicroSky: Synthetic biology: A novel methanol-free system using the HSP70 promoter in K. phaffii enables safe, heat-induced expression of recombinant proteins. Fe₃O₄ nanoparticle-immobilized cells boost secretion—ideal for food/pharma-grade production! doi.org/10.1111/1751...

#MicroSky: GUT HEALTH _One Health: Bifidobacterium infantis converts tryptophan into beneficial indole derivatives (ILA, IAA, ICA), with yields boosted by higher substrate levels. This highlights its key role in gut health via metabolic modulation. doi.org/10.1111/1751...

#MicroSky: Special Issue on “Recent advances in anaerobic digestion processes for energy recovery and production of value-added products". Submit your manuscript online at: mc.manuscriptcentral.com/microbio. Deadline 📆 30 November 2025. Thanks for RT

#MicroSky: DIAGNOSTIC: MALDI-TOF MS + machine learning enables rapid detection of carbapenem-resistant K. pneumoniae via key mass peak. A faster, smarter alternative to traditional resistance tests. Read Ye et al in MBT. doi.org/10.1111/1751...

#MicroSky: Yu et al studied how bacteria cope with high levels of hydrogen peroxide. By tracking gene activity, it was found they boost defences, repair DNA & adjust metabolism to survive. Relevant info for biotech processes and industrial production of toxins! doi.org/10.1111/1751...

#MicroSky: Chicken manure is a rich, underused source of bile acids! Holert et al show chenodeoxycholic acid can be extracted & directly converted into valuable ursodeoxycholic acid for pharma use. doi.org/10.1111/1751...

#MicroSky: Special Issue on “The Contribution of Microbial Biotechnology to Sustainable Development Goal 3: Ensure healthy lives and promote well-being for all at all ages". Submit your manuscript online at: mc.manuscriptcentral.com/microbio. Deadline 📆 20 December 2025. Thanks for RT

#MicroSky: Molecular and functional assays highlight the relevance of species-specific polymorphisms in a B12 riboswitch of the Mycobacterium genus. Campos-Pardos et al provide proof-of-concept to engineer a whole-cell biosensor capable of detecting vitamin B12. doi.org/10.1111/1751...

#MicroSky: Synthetic Biology: Zhang et al. introduce a modular strategy employing toehold switches for screening optimal synthetic acid-tolerance modules from a large library. Stepwise evaluation confirms enhanced robustness and productivity. Broad application power! doi.org/10.1111/1751...

#MicroSky: Special Issue on “Innovations in Microbial Biotechnology for Sustainability". Submit your manuscript online at: mc.manuscriptcentral.com/microbio. Deadline 📆 31October 2025. Thanks for RT

#MicroSky: Brewer's spent grain (BSG), a by-product of beer-making, poses an environmental challenge—but also holds untapped nutritional value. Fermentation by non-conventional starters is the key to unlocking its potential! doi.org/10.1111/1751...

#MicroSky: Enzyme engineering: D-Acylases revisited and D-methionine successfully produced!. First structural insight into KleDacyl’s α/β domain unlocks engineering potential! doi.org/10.1111/1751...

#MicroSky: Harding et al explore the use of bacteriophage P22 virus-like particles to encapsulate recombinantly expressed bioactive peptides, enabling the production of therapeutically valuable linear and cyclic peptides in Escherichia coli. doi.org/10.1111/1751...

#MicroSky: Special Issue on “Recent advances in anaerobic digestion processes for energy recovery and production of value-added products". Submit your manuscript online at: mc.manuscriptcentral.com/microbio. Deadline 📆 30 November 2025. Thanks for RT

#MicroSky: P. aeruginosa poses a major challenge due to drug resistance. Ofori et al report that aminoglycoside efficacy is waning, but they describe new strategies: combinational therapies, adjuvants, silver and others show promise in re-sensitizing resistant strains. doi.org/10.1111/1751...

#MicroSky: Amino acids in cucumber root exudates trigger Bacillus spore germination via GerA, enhancing root colonization and plant growth. Tao et al have identified key germinators and receptors, advancing targeted biofertilizer applications for improved agriculture. doi.org/10.1111/1751...

#MicroSky: Gu et al report that PEG pre-treatment boosts colonization, oral gavage sustains it, and enema resolves dysbiosis faster. Selective colonization remains a challenge, highlighting the need for tailored FMT strategies in preclinical models. . doi.org/10.1111/1751...

#MicroSky: Boosting biovanillin – the most demanded flavoring compound! P. putida KT2440 was engineered to convert ferulic acid to vanillin. Using a polystyrene-based resin to remove toxic vanillin during conversion raised yield from 0.6 g/L to >3.3 g/L. doi.org/10.1111/1751...

#MicroSky: Special Issue on “Innovations in Microbial Biotechnology for Sustainability". Submit your manuscript online at: mc.manuscriptcentral.com/microbio. Deadline 📆 31October 2025. Thanks for RT

#MicroSky: Boya et al reveal halogenated that anilines 4B3CA & 3,5-DBA are promising antimicrobial & antibiofilm molecules against ESKAPE pathogens (biofilm IC₅₀ = 10 μg/mL). They inhibit virulence factors & target adenylate cyclase. In silico data open further development. doi.org/10.1111/1751...