David MacPherson Lab

Fred Hutch study finds genetic driver of drug resistance in small cell lung cancer A study of human tumor cells implanted in mice from the MacPherson Lab at Fred Hutch describes a new way to screen for the genes that matter in chemotherapy resistance in small cell lung cancer.

In work published in Science Advances, researchers in the @davidmacphersonlab.bsky.social used #CRISPRCas9 on #SCLC tumor cells to better model how tumors that initially respond to chemotherapy become resistant. www.fredhutch.org/en/news/cent...

Not a small part! Thanks to you and Noah for such a fantastic collaboration

This work was jointly led by graduate students Lauren Brumage and Scott Best @fredhutch.bsky.social. Grateful for key collaborators including @barzin-nabet.bsky.social, @lucasbsullivan.bsky.social as well as reviewers and editors at Science Advances and funding from the NCI and Fred Hutch 2/2

Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2

Postdoc salaries at FH follow a WA state law for exempt employees - big jumps in salary coming this jan 2025 and in 2 years

Fred Hutchinson Cancer Center Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

The MacPherson lab at Fred Hutch is hiring a postdoc to study the biology of small cell lung cancer. We employ in vivo models, genetic screens and genomic approaches to understand + therapeutically target subsets of SCLC. $78K salary ⬆️ to >$90K after 2 yrs
careers-fhcrc.icims.com/jobs/28757/p...

Very cool Trudy and Abbie, exciting to model and understand origins of this SCLC subset!

You, too, Amy, thanks!

Hello Bluesky! I’m a Professor at Fred Hutch and our lab studies the biology of small cell lung cancer. Using mouse and PDX models, cell-based and in vivo genetic screens, and genomic approaches, we seek to understand biologically distinct subsets of SCLC and their therapeutic vulnerabilities.

Starting a list of oncology related peopl. Please tell me more to add. Or any similar listd go.bsky.app/GKXp9Fy @n8pennell.bsky.social

go.bsky.app/7xTwrrn

Can you please add me?