David Breslow Lab

“The Senate Committee on Appropriations is scheduled to release its proposal for NIH’s 2026 budget later this week…The committee could include language that would prohibit the multiyear funding plan or extend the timeline for the transition.”🧪

Want to publish a NIH-funded paper in Nature? Well - unless your institution has an agreement with Springer, you'll have to be mega-rich to be compliant with NIH's new no-embargo policy. Springer is insisting on gold OA - that's $12,690 and that's extortion.

That is very helpful! Colleague here was just persuaded to pay a >$10k APC for a Cell Press journal - nice to know this may be unnecessary

Nice that JCB / RUP has clear guidance with their ‘Green’ option. Any idea if Cell Press or Nature journals allow this?

the word alert is in a purple circle ALT: the word alert is in a purple circle

ACTION ITEM-----ACTION ITEM

Implementation of Schedule F

This is what a lot of us have been worried about.

This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.

BUT THERE IS A COMMENT PERIOD...

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We're live! @inikon.bsky.social used modular proximity labeling to identify ciliary EV cargo in #celegans. This EV-TurboID approach can be applied in cell- & tissue-specific manners to define the composition of distinct EV subtypes, a major challenge of the EV field.

www.nature.com/articles/s41...

Trump promised scientific breakthroughs. Researchers say he’s breaking science. NIH funding for biomedical research has abruptly fallen by billions of dollars, with many grant decisions on hold. Trump officials say they’re reviewing the agency.

Powerful new Washington Post story up...

wapo.st/426d9fT

(Gift link)

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Application at NINDS now shows Apr 10 council date in eRA Commons. NIGMS application shows May 22, which is the date that was planned by GM for the following cycle. Both apps were originally supposed to have Council in Feb...

Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms The flagellum of Trypanosoma brucei drives the parasite’s characteristic screw-like motion and is essential for its replication, transmission, and pathogenesis. However, the molecular details of this ...

Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms | Science www.science.org/doi/10.1126/...

Congrats to Anna Seminara on her paper out today in @cp-cellchembiol.bsky.social reporting a new approach to metabolite depletion using a bacterial ABC transporter, applied to study the antioxidant ergothioneine in H. pylori!

Stand up for science event on March 4th at 5:30pm at East Rock Brewery!

CT folks! Let’s come together and make signs for #standupforscience! @luskinglab.bsky.social

A versatile cohesion manipulation system reveals CENP-A dysfunction accelerates female reproductive age-related egg aneuploidy. Female reproductive aging is accompanied by a dramatic rise in the incidence of egg aneuploidy. Premature loss of chromosome cohesion proteins and untimely separation of chromosomes is thought to unde...

Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...

Trump's illegal NIH cuts mean cancer researchers would be laid off, sick kids going without treatment, and more. These cuts would be DEVASTATING for lifesaving research.

Some Republicans have said they agree—but they just blocked my amendment to reverse Trump's NIH cuts anyway.

Trump Administration Stalls Scientific Research Despite Court Ruling (Gift Article) Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.

Trump Administration Stalls Scientific Research Despite Court Ruling. Story by Ben Mueller. Gift link: nyti.ms/435szDm

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget.


https://go.nature.com/4gM6oW4

So can anyone shed light on how long they can legally keep the NIH communications freeze in place? It's been a long time since February 1 came and went. Is there any legal recourse?

Federal Register hold makes ‘end run’ around court pause on NIH funding freeze NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

A large portion of grants awarded by the U.S. National Institutes of Health cannot be funded for the foreseeable future because of an indefinite hold on submissions to the Federal Register, according to an email reviewed by The Transmitter.

By @avaskham.bsky.social

bit.ly/3X8ngz8

Tomorrow!! Join us in New Haven, CT at 5:15 on the green or find one near you. @aaup.bsky.social

I still don't think it's sunk in to many that after February 20th, there ain't no study sections.

Are these meetings going to be rescheduled for Mar/Apr or skipped entirely? NIGMS council was maybe moved to Apr but is this confirmed? @jeremymberg.bsky.social A de-facto funding freeze on new and renewal grants if there are no council meetings...

National Advisory Council (NANDSC) Meeting - Winter 2025 - Postponed Time: TBDLocation: Remote/ZoomContact: Tim LydenThe 225th meeting of the National Advisory Neurological Disorders and Stroke Council is postponed.

Today the NINDS council meeting site was updated to indicate postponement (was scheduled for today).
www.ninds.nih.gov/news-events/...

Looks like today's NINDS council meeting was canceled...

Deep Cuts to Medical Research Funds Could Hobble University Budgets Grants from the National Institutes of Health come with additional money for overhead. Proposed funding cuts would leave colleges with large budget gaps.

NEW: The N.I.H. will cut about $4 Billion from federal research grants that support cancer, virus and heart disease research.

#Project2025 called for the cuts to end subsidies to "leftist" university agendas.

www.nytimes.com/2025/02/07/u...

iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...

Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel.

Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.