Antonio J. Pérez Pulido 🧬🦠💻🦼

Leyendo la novela de @sotocolas.bsky.social. Gran trama y especialmente me está gustando mucho la ambientación. Realmente te crees que estás en la Sevilla de después de la época de los descubrimientos. Me está enganchado...

Una enzima del metabolismo lipídico se revela como nueva vía para elevar los niveles de la proteína clave en la Atrofia Muscular Espinal

www.upo.es/diario/cienc...

As always, thanks to @agarvil.bsky.social (the protagonist of this serendipitous discovery), Antonio Moreno, Alex Rubio, and the original work of the group's new thesis candidate, Elisa Luque.

But it was contamination. Bit by bit, we pieced it together — and here it is, the complete genome assembly of a new A. guillouiae strain.

This project began by pure serendipity: while analyzing a soil mite genome, Oppiella nova. We found sequences from an Acinetobacter bacteriophage. It initially led us to believe that this was a case of horizontal transfer.

Discovery of a bacteriophage sequence in a mite genome assembly reveals bacterial contamination and opens new possibilities for exploring arthropod symbionts While studying the integration site of a bacteriophage associated with the bacterium Acinetobacter baumannii, we found a genome assembly of the mite Oppiella nova that contained a homologous sequence ...

New article from our UPOBioinfo group! 🧬
We’re now exploring bacteria hidden in arthropod genome assemblies @microbiologysociety.org @cabd-upo-csic.bsky.social

www.microbiologyresearch.org/content/jour...

Gracias por el apoyo y financiación a @FundameNet @ElcaminodeElena y @galici_ame

This suggests that sphingolipids such as ceramide could be a possible biomarker for disease progression and monitoring.

We have found a modifier of SMN, acid sphingomyelinase, and drugs that inhibit it and increase SMN protein levels. Most importantly, we have linked sphingolipid metabolism to SMA for the first time.

Inhibition of acid sphingomyelinase increases SMN levels and connects sphingolipid metabolism to Spinal Muscular Atrophy Spinal Muscular Atrophy (SMA) is a moderately rare disease that causes progressive motor neuron degeneration and presents the highest neonatal death r…

We are proud to present our multidisciplinary collaboration (bioinformatics, nematodes, cell cultures) on Spinal Muscular Atrophy (SMA). It has been fascinating to work on my disease with this great team!

New photo of UPOBioinfo Group 2025-2026 - Bacteriophages and their relationship with CRISPR-Cas and other defense systems in bacteria.

Looking forward to a year of fascinating stories about bacteria and phages!

Visual description: Features a background image of Belfast City Hall at night. Text reads 'Annual 2026 Conference' and 'ICC Belfast, UK 13 - 16 2026'. Features the 'Get Involved' logo, as well as the 'Microbiology Society' logo and 'visit Belfast' logo.

Join us for Annual Conference 2026!

Abstract submission and registration are open for the UK’s largest annual gathering of microbiologists.
Held in Belfast, UK, this year’s Conference also features two-day attendance tickets.

Me apunto el libro, @lluismontoliu.bsky.social

Un tipo llamado Fred Sanger - Gen-Ética Este verano hemos pasado unos días en Cambridge (Reino Unido), ciudad universitaria por excelencia y sede de prestigiosos e históricos centros de investigación. Estos centros convierten a Cambridge en...

Un tipo llamado Fred Sanger montoliu.naukas.com/2025/08/24/u...

Un científico de los de verdad, no de los que quieren ahora. En esos tiempos, publicar era sinónimo de hacer Ciencia y sólo publicar no era hacer Ciencia.

🆘 #Flybase needs YOUR help🪰

Now reading... At last I can travel around Australia!!!

This is a great result from Antonio Moreno's thesis, with the essential help of Alex Rubio and Andrés Garzón, and the invaluable collaboration of Younes Smani.

The evolutionary replacement of restriction-modification by Ssp antiviral systems is associated with the distribution of prophages in the major clonal group of Acinetobacter baumannii | mBio Acinetobacter baumannii is a bacterium of great concern in clinical contexts due to the plasticity of its genome and its resistance to antibiotics. Its cells are infected by a multitude of bacteriophages, and the bacterium defends itself with dozens of ...

Today, our UPOBioinfo group presents the defensome of Acinetobacter baumannii.
Do you know about its concerning Global Clone 2? Well, part of its success could be due to the replacement of restriction-modification systems by Ssp antiviral systems.

What a wonderful book for summer! It has been amazing. Thanks @edyong209.bsky.social

Registration is open for the Microbial Genomics of Eukaryotes meeting in Glasgow! This event will showcase diverse scientific achievements in eukaryotic genome research. Register now and submit your abstract by 12 August: microb.io/MicroGenomic...

sorry, in here it is better than multiplied (X)...:
@microbiologysociety.org

And proud that it has been published in Microbial Genomics, the journal of @MicrobioSoc, a membership charity and not-for-profit publisher that supports inclusive research.

#Irene has been an excellent student of our master's degree in Advanced Bioinformatics Analysis and this has been the result of her Master's Thesis, tutored by #AlexRubio and myself.

Bacteriophages in Pseudomonas aeruginosa evade the CRISPR-Cas I-F system by depletion of PAM sequences Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins systems provide bacteria with an adaptive immune system against exogenous sequences, such as pla...

New paper published in our computational biology group for the study of phages, of which we are especially proud: "Bacteriophages in Pseudomonas aeruginosa evade the CRISPR-Cas I-F system by depletion of PAM sequences".

Qué orgulloso de mis niñ@s, que se van haciendo mayores 🤍

YouTube video by Fundame España Lo que enseñan virus y bacterias para curar enfermedades. Antonio J Pérez Pulido . AMEnízAME

Gran Video Podcast de Rubén en Fundame. Si quieres saber más sobre AME y lucha entre fagos, dejo por aquí la entrevista que me hicieron y que acaba de ser publicada.
youtu.be/hEl1PnVJl5I?...

Por qué sufro la enfermedad más bonita del mundo (y la más cara de tratar) La atrofia muscular espinal, que sufre el autor del artículo, es una de las enfermedades genéticas con mayor mortalidad asociada. Y también la más cara de curar, lo que no le quita su “encanto especial” a nivel molecular.

Hoy es el Día Mundial de las #EnfermedadesRaras y recordamos que @ajperezpulido.bsky.social (@pablodeolavide.upo.es) ya nos contó que sufre la 'enfermedad más bonita del mundo':

Convendría parar un poco y tomar decisiones unánimes (que por otro lado, no las va a haber). Pero es claro que las revistas nacieron en las sociedades científicas con el objetivo de publicar Ciencia. Y lo de ahora, con las editoriales, tod@s sabemos que se llama negocio.

Actualización: por si te parecía poco escándalo no poder publicar, ahora ya tampoco podrás acceder gratis (por lo visto había alguna ONG que pagaba las suscripciones)

Y mientras tanto dejamos que la bola de nieve siga y siga creciendo...