Kylene Harold

Can "glitches" in how the heart processes sugar lead to dangerous arrhythmias? 🍬➡️💔

Our new study now in preprint shows that glycolytic dysregulation at the PFK nexus is enough to cause electrical instability in the heart. Check out our findings here:

Incredible friend, peer mentor, adventurous collaborator (patcher of “bricks”), and now DR. Blankenship @harrisedwardb.bsky.social defended the most brilliant dissertation yesterday.

Excellent review highlighting maladaptive implications of sustained O-GlcNAcylation in the diabetic heart, as well as gaps in understanding of the mechanisms underlying cardiac O-GlcNAc regulation.

O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder Matheny-Rabun and colleagues discover that O-GlcNAc modification of rate-limiting enzymes within the N-glycosylation pathway impacts their function, drawing a connection between two spatially separate...

O-GlcNAc modification of enzymes within the N-glycosylation pathway impacts their function, revealing a connection between these two distinct glycosylation pathways.
www.cell.com/cell-reports...

Humphries lab, represent. Grad student, Kylene Harold, presenting her work on our PFKFB2 knockout mouse. 🫀

OMRF discovers new chemical link to Alzheimer’s Findings may explain mood changes that precede disease

How’s this for a first post?
New publication in Nature Communications about the role of dopamine in Alzheimer’s disease⤵️
omrf.org/2024/11/12/o...