Thomas Lecuit

Thomas Lecuit

@thomaslecuit.bsky.social

How are biological forms encoded? Group leader at IBDM Marseille, director of Turing Center for living systems (CENTURI). Professor at Collège de France, Paris: Dynamics of living systems

1,995 Followers 156 Following 79 Posts Joined Nov 2024
2 days ago
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Applications open for the CENTURI Hackathon for Quantitative Biology 2026!

🧬💻 Join us in Marseille (June 5–7) for a weekend of coding at the interface of CS & life sciences.

📝Apply by May 6: centuri-livingsystems.org/application-...

Event Details: centuri-livingsystems.org/hackathon-20...

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5 days ago
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"Forme et croissance" de D'Arcy Thompson : le vivant, mode d'emploi “Forme et croissance”, livre phare de D’Arcy Thompson paru en 1917, a marqué un tournant en biologie en expliquant la variété des formes du vivant par les lois physiques. Comment ce premier travail de...

A 16h sur @franceculture.fr Sciences Chrono parle de "Forme et croissance" de D'Arcy Thompson. Comment ce livre paru en 1917 a-t-il transformé l'histoire de la biologie et de notre compréhension de la morphogénèse? Quelles lois physiques et mathématiques sous-tendent les formes multiples du vivant ?

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1 week ago
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Wonderful to be part of exciting Program at Harvard University & CMSA, Mathematics &Biology: Morphometry, Morphogenesis and Mathematics. Thank you 🙏🏼 and congrats to organizers for their invitation. Great to see and discuss with wonderful colleagues, not least @akankshi.bsky.social! 🤩

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2 weeks ago
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Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate - Nature The choanoflagellate Choanoeca flexa forms motile and contractile cell monolayers purely clonally, purely aggregatively or through a combination of both processes depending on environmental condi...

Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate www.nature.com/articles/s41... #jcampubs

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2 weeks ago
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Spatial patterning of contractility by a self-organized mechanogen activity gradient underlies Drosophila gastrulation - Nature Communications During morphogenesis patterned contractility drives tissue shape changes. Here they show that GPCR signaling and integrin activation give rise to a dynamically translocating gradient of contractility ...

New paper out! In this project, we focused on the question how tissue mechanics is spatially controlled during development. We show that the GPCR ligand Fog acts as a “mechanogen” during Drosophila gastrulation, driving a self-organized wave of tissue invagination:
www.nature.com/articles/s41...

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2 weeks ago
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Spring is just around the corner in Marseille 😊

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3 weeks ago
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Very sad news. Gail Martin (1944-2026) was a figure in developmental biology. She pioneered the field of ES cells.
A great colleague, a friend and a lovely person.

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1 month ago
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Huge congrats to @manuelthery.bsky.social and all the Cytomorpho lab. The "Living Architectures" performance at @museeorsay.bsky.social was breathtakingly beautiful

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1 month ago
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A few seconds of eternity: From microscope to museum❣️
It was truly delightful to be part of this project, celebrating life as a continuous dance of creation, collapse, and renewal. 🔄
Kudos to @manuelthery.bsky.social @lblanchoin.bsky.social #cytomorpholab members, and @museeorsay.bsky.social

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1 month ago
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This weekend we projected cells and filaments on the roof of the @museeorsay.bsky.social in Paris, then we contracted it with a pinch of myosin.
And it was fabulous!

Grateful to have been part of this art/science project & thx to @manuelthery.bsky.social @lblanchoin.bsky.social & the CytoMorphoLab

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3 weeks ago
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Very nice dinner with colleagues from Institut Pasteur, Francois Schweisguth, Romain @levayerr.bsky.social , Thomas Gregor and @jeromegros.bsky.social 🤩. I look forward to more discussions and to giving my seminar tomorrow ! Thank you for the great invitation.

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1 month ago
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Bluesky Map Interactive map of 3.4 million Bluesky users, visualised by their follower pattern.

I made a map of 3.4 million Bluesky users - see if you can find yourself!

bluesky-map.theo.io

I've seen some similar projects, but IMO this seems to better capture some of the fine-grained detail

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1 month ago
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Last but not least, @NCBS_Bangalore hosts remarkable plants and biodiversity. The garden is beautiful, at any season. Always refreshing to be exposed to nature while working on « life in a lab »… a glimpse below 🤩

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1 month ago
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Another treat visiting ICTS, welcomed & stimulated by @vijaykrishnamurthy.bsky.social Exciting work on non-trivial & remarkable interactions btw mechanics & geometry in morphogenesis.
Check what will come out…
+ Do visit ICTS biological physics groups. 🙏🏼 for hosting me!

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1 month ago
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A very interesting article « De novo emergence of metabolically active protocols ». Complex chemistry, organisation from few input constituants. Very intriguing.
Congrats Shashi Thutupalli and colleagues @stpalli
Link:
arxiv.org/abs/2601.11013

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1 month ago
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Among outstanding scientists @ncbsbangalore.bsky.social are the physicists. Colleagues & friends Madan Rao, Mukund Thattai, @stpalli Shashi Thutupalli, w. visitors Shiva GV, Irene Giardina. Always learn from them. Great discussions on Information & computation in biology.

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1 month ago
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15 yrs ago, I spent 1y sabbatical @ncbsbangalore.bsky.social , with family, hosted by @kvijayraghavan.bsky.social , starting long standing coll. with Jitu Mayor & Madan Rao. The discovery of this exceptionally diverse, creative & energetic community transformed me 🤩. Huge 🙏🏼

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1 month ago
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Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion | PNAS Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is know...

Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...

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1 month ago
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In remembrance of Peer Bork  | EMBL EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.

very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...

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2 months ago
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Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de

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1 month ago
A screenshot of the 'The hard truth about how hard it is to publish in Development' article PDF.

The hard truth about how hard it is to publish in Development

Editor-in-Chief @jamesbriscoe.bsky.social leads our team of Academic Editors in addressing the perception that Development is ‘too hard to publish in’ by discussing the journal's review process.

doi.org/10.1242/dev....

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1 month ago
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Is there a mathematics of discontinuous behavior? Christopher Zeeman was a leading proponent of Catastrophe Theory, a topological approach to sudden change that underpins much of today’s work on tipping points. This is his beautiful 1976 paper in @sciam.bsky.social www.jstor.org/stable/pdf/2...

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2 months ago
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Wonderful dinner in Paris with Claude Desplan, 1st mentor (who led me to become a scientist because his lab was such a cool place) & friend. Thank you for your energy, shear passion for science and sense of humour 🤩. And see you soon at the College de France in May June for your lecture series.

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2 months ago
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How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? 🤔

We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.

buff.ly/w56OUJT

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2 months ago

Super nice to see this awesome set of lectures online! A really timely perspective on biology through the lens of information, which inspires much of our own research as well.

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2 months ago

The CENTURI PhD Call 2026 is still ongoing. Applications are open until the end of the month, on January 28th!

Visit centuri-livingsystems.org/recruitment/ to apply.

#PHD #CENTURI

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2 months ago
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Here is the link to download the PDF of my course#5 on Biological computation. I present & discuss Self-tuning, Adaptation and Learning in biological (non-neuronal) systems, in particular during embryonic development.
This course contains various personal ideas/proposals.
tinyurl.com/hcpwsbtm

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2 months ago
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Qu’est-ce que l’information biologique (suite) ? (5) - Thomas Lecuit (2025-2026) Enseignement 2025-2026 : Qu’est-ce que l’information biologique (suite) ? Cours du 18 décembre 2025 : Apprentissage non neuronal dans un système vivant Professeur : Thomas Lecuit Chaire Dynamiques du vivant Retrouvez les enregistrements audios et vidéos du cycle : https://www.college-de-france.fr/fr/agenda/cours/qu-est-ce-que-information-biologique Tous les enseignements du Pr Thomas Lecuit : https://www.college-de-france.fr/chaire/thomas-lecuit-dynamiques-du-vivant-chaire-statutaire https://www.youtube.com/playlist?list=PLOj9pZ2YNGZ84uMY6DhPnqpL1rq5qNAVJ Le Collège de France est une institution de recherche fondamentale dans tous les domaines de la connaissance et un lieu de diffusion du « savoir en train de se faire » ouvert à tous. Les cours, séminaires, colloques sont enregistrés puis mis à disposition du public sur le site internet du Collège de France. Découvrez toutes les ressources du Collège de France : https://www.college-de-france.fr Soutenir le Collège de France : https://www.fondation-cdf.fr/faire-un-don Suivez-nous sur : Threads : https://www.threads.net/@collegedefrance Bluesky : https://bsky.app/profile/college-de-france.fr Facebook : https://www.facebook.com/College.de.France Instagram : https://www.instagram.com/collegedefrance LinkedIn : https://fr.linkedin.com/company/coll%C3%A8gedefrance

Please find below the link to watch the VIDEO of my course#5 @college-de-france.fr on Biological computation. I present and discuss Self-tuning, Adaptation and Learning in biological (non/neuronal) systems, in particular during embryonic development.
Enjoy!

tinyurl.com/4pv95an9

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2 months ago
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#Science #Biologie
🧬 « Qu’est-ce que l’information biologique (suite) ? » 
🖥️ Le cours du Pr @thomaslecuit.bsky.social, titulaire de la chaire Dynamiques du vivant, est terminé... mais toutes les vidéos sont à retrouver sur notre site web !
👉 https://tinyurl.com/bddcxahd

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2 months ago
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And here is the PDF of the 4th course @college-de-france.fr. You will find the justification and presentation of geometric representation of cell decisions, a parsimonious mathematical model for signalling and cell state transitions

tinyurl.com/yc7u296j

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