Dr David Joffe MB BS(Hons), PhD, FRACP's Avatar

Dr David Joffe MB BS(Hons), PhD, FRACP

@davidjoffe64.bsky.social

Respiratory and Sleep Medicine Neurobiology and Long CΓΆvid WHN Long Covid Working Group Vice Chair

12,068 Followers  |  512 Following  |  3,840 Posts  |  Joined: 19.09.2023  |  1.9909

Latest posts by davidjoffe64.bsky.social on Bluesky

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🧠 Daily Feed of Brain Damage 🧠

doi.org/10.1016/j.ge...

04.12.2025 06:50 β€” πŸ‘ 57    πŸ” 20    πŸ’¬ 1    πŸ“Œ 4
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Adipose Tissue in SARS‐CoV‐2 Viral Tropism, Viral Replication, and the Concept of a Viral Reservoir: An Update Adipose tissue as a potential reservoir for and modifier of SARS-CoV-2 infection and its complications. Schematic demonstrating the differences in subcutaneous and visceral adipose tissue and infecti...

The relevance of this observation in relationship to Long CΓΆvid, weight gain and availability of more fuel to burn the ongoing cytokine storm should be lost on no one.

Waste of precious mitochondria... Just fat being stored. Clever virus

doi.org/10.1002/oby....

04.12.2025 06:45 β€” πŸ‘ 35    πŸ” 18    πŸ’¬ 0    πŸ“Œ 0
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Sleep phenotypes of Ξ±-synucleinopathies and tauopathies with Parkinsonism In neurodegenerative Parkinsonism, biomarkers of Ξ±-synucleinopathy (Syn) or tauopathy (Tau) are an unmet need. Rapid eye movement (REM) sleep behavior disorder (RBD) strongly indicates Syn. However, i...

People keep wondering why I am concerned about RBD in Long C-19

www.prd-journal.com/article/S135...

02.12.2025 22:04 β€” πŸ‘ 29    πŸ” 9    πŸ’¬ 0    πŸ“Œ 2
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Adolescent Depressive Symptom Trajectories Before and After the COVID-19 Pandemic This cohort study examines depression symptom trajectories from before, during, and after the lockdown stages of the COVID-19 pandemic and identifies factors associated with risk and resilience among ...

🧠 Daily Feed of Brain Damage 🧠

jamanetwork.com/journals/jam...

02.12.2025 11:21 β€” πŸ‘ 24    πŸ” 6    πŸ’¬ 0    πŸ“Œ 1
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<em>Acta Paediatrica</em> | Paediatrics Journal | Wiley Online Library Aim We aimed to investigate if the incidence of type 1 diabetes increased in children during the SARS-CoV-2 pandemic and whether SARS-CoV-2 antibodies were more frequently present at diagnosis compa...

CΓΈvid is DEFINITELY not cool for kids

πŸ€¬πŸ€¬β€ΌοΈ

onlinelibrary.wiley.com/doi/10.1111/...

02.12.2025 11:13 β€” πŸ‘ 36    πŸ” 12    πŸ’¬ 0    πŸ“Œ 1

@gtconway.bsky.social

He's a completely unhinged and dangerous dickhead... Just like the POTUS who appointed him.

I have come to realise that America is in the throes of democratic death....

Watching a once decent people committing suicide in real time is ugly.

I expect zero accountability

02.12.2025 08:36 β€” πŸ‘ 19    πŸ” 3    πŸ’¬ 2    πŸ“Œ 0

πŸ˜‚πŸ˜‚πŸ€¦πŸ»β€β™‚οΈ

02.12.2025 07:56 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Redirecting

Long C-19 just got a whole lot LOOOOONGERπŸ˜³πŸ˜³β€ΌοΈ

Good thing we've closed all the Clinics
🀬🀬

doi.org/10.1016/j.la...

02.12.2025 04:44 β€” πŸ‘ 24    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0

Kill-Dorp...

A special kind of stupid

02.12.2025 04:20 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Well, 5 years later we are still blaming immunity debt πŸ€¦πŸ»β€β™‚οΈπŸ€¦πŸ»β€β™‚οΈ

30.11.2025 18:52 β€” πŸ‘ 69    πŸ” 16    πŸ’¬ 2    πŸ“Œ 0

Tell me again how CΓΈvid is cool for kids?

www.mdpi.com/1648-9144/61...

30.11.2025 11:19 β€” πŸ‘ 47    πŸ” 14    πŸ’¬ 2    πŸ“Œ 3

You went to great lengths for this crap paper to be pulled. Even then, the Academic ranks closed around the authors to protect them from the punishment they richly deserved 🀬🀬

29.11.2025 23:04 β€” πŸ‘ 33    πŸ” 9    πŸ’¬ 0    πŸ“Œ 0

Whatever happened to

"RCT or STFU"???

Grifting scientists have a way of gathering.

@gavinyamey.bsky.social the collective noun is MAHA πŸ™πŸ»

29.11.2025 19:32 β€” πŸ‘ 13    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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Fatigue in children and young people up to 24 months after infection with SARS-CoV-2 - Scientific Reports Scientific Reports - Fatigue in children and young people up to 24 months after infection with SARS-CoV-2

🧠 Daily Feed of Brain Damage 🧠

Tell me again that CΓΆvid doesn't effect children πŸ€¬β€ΌοΈ

www.nature.com/articles/s41...

29.11.2025 19:29 β€” πŸ‘ 119    πŸ” 61    πŸ’¬ 4    πŸ“Œ 2

πŸ˜ŽπŸ˜‚πŸ˜‚πŸ’–

29.11.2025 12:33 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

πŸ™πŸ»πŸ™πŸ»πŸ˜Š

29.11.2025 12:21 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Thank you πŸ’–πŸ™πŸ»

21 and "some months" πŸ˜‚πŸ˜‚

29.11.2025 12:06 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

It was lovely not to be working πŸ˜ŠπŸ˜ŠπŸ‘πŸ»

29.11.2025 12:05 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Not Bad, Ian

Had a birthday on Wednesday... Gave myself two days off...

Really needed a break!

Set up a new PC for the Boss, in her refurbished office, finally got shit done🦾

Spent two hours getting my "Working with Children" check sorted. FMD🀬

Services NSW... Where🧠's went to dieπŸ˜‚

29.11.2025 10:47 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 3    πŸ“Œ 0

😘😘

29.11.2025 09:29 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Altered Brain Tissue Microstructure and Neurochemical Profiles in Long COVID and Recovered COVID-19 Individuals: A multimodal MRI Study Diverse neurological symptoms are experienced by long COVID and COVID-19 recovered individuals. However, the long-term effects of SARS-CoV-2 in the br…

🧠 Daily Feed of Brain Damage 🧠

www.sciencedirect.com/science/arti...

28.11.2025 18:50 β€” πŸ‘ 39    πŸ” 15    πŸ’¬ 0    πŸ“Œ 1

Thankfully, home delivery is free for us.

28.11.2025 18:25 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19 - Nature Communications Post-acute sequelae of SARS-CoV-2 (PASC) have been linked to brain alterations, but association with cognitive problems are not well understood. Here, the authors analyze blood proteins and brain MRI ...

🧠 Daily Feed of Brain Damage 🧠

www.nature.com/articles/s41...

28.11.2025 02:37 β€” πŸ‘ 25    πŸ” 11    πŸ’¬ 0    πŸ“Œ 1

The Grenfell flats catastrophe in the UK was a stark warning....

Humans are poor learners when developers can cut corners.

27.11.2025 19:21 β€” πŸ‘ 30    πŸ” 9    πŸ’¬ 2    πŸ“Œ 0

Like I said....

Fort once, it's not CΓΈvid related brain science

27.11.2025 11:26 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Biased histamine signaling selectively gates fat preference Zheng et al. uncover the neural basis for specific food preferences, showing that separate thalamic populations mediate intake of high-fat and high-sugar diets. They identify a histamine H3 receptor-m...

Might explain much about the weight gain following C-19

www.cell.com/neuron/fullt...

27.11.2025 11:24 β€” πŸ‘ 35    πŸ” 15    πŸ’¬ 1    πŸ“Œ 0
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Topological turning points across the human lifespan - Nature Communications Researchers discovered five phases of brain rewiring across the lifespan. The eras of childhood, adolescence, adulthood, early aging, and late aging each have characteristic rewiring of structural con...

Really fascinating science...

For once, not CΓΈvid brain damage

www.nature.com/articles/s41...

27.11.2025 10:58 β€” πŸ‘ 21    πŸ” 7    πŸ’¬ 2    πŸ“Œ 0
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Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19 - Nature Communications Post-acute sequelae of SARS-CoV-2 (PASC) have been linked to brain alterations, but association with cognitive problems are not well understood. Here, the authors analyze blood proteins and brain MRI ...

🧠 Daily Feed of Brain Damage 🧠

@atranscendedman.bsky.social πŸ’”

www.nature.com/articles/s41...

27.11.2025 08:56 β€” πŸ‘ 37    πŸ” 12    πŸ’¬ 1    πŸ“Œ 2

There's the added issue of repeated infections within that window...

And that's the kicker‼️

26.11.2025 22:28 β€” πŸ‘ 8    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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T cell-driven sustained inflammation and immune dysregulation mimicking immunosenescence for up to three years post-COVID-19 - Immunity & Inflammation Long COVID has emerged as a major global health concern, yet the long-term trajectory of immune recovery and its contribution to persistent symptoms remain to be elucidated. Here, we conducted a three...

The #Leonardi_Effect is very long‼️

link.springer.com/article/10.1...

26.11.2025 21:11 β€” πŸ‘ 55    πŸ” 17    πŸ’¬ 5    πŸ“Œ 1

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