Dr David Joffe MB BS(Hons), PhD, FRACP

Aggregation potency and proinflammatory effects of SARS-CoV-2 proteins - Scientific Reports Scientific Reports - Aggregation potency and proinflammatory effects of SARS-CoV-2 proteins

🧠 Daily Feed of Brain Damage 🧠

Endless carnage🤬‼️

www.nature.com/articles/s41...

Kids and Covid....

WTAF are we doing ‼️‼️🤬

brieflands.com/articles/irc...

Mapping the peripheral immune landscape of Parkinson’s disease patients with single-cell sequencing Changes in the immune system have been linked to Parkinson’s disease. By analysing more than 78 000 immune cells, Moquin-Beaudry et al. identify shifts in

Hmmmm.....

doi.org/10.1093/brai...

Thanks Ros....

I'm always grateful to those adding an explanation...

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🧠 Daily Feed of Brain Damage 🧠

With an editorial from @daniellebeckman.bsky.social

onlinelibrary.wiley.com/doi/10.1111/...

No end in sight❤️❤️🔥

www.nature.com/articles/s41...

Epigenetic differences at immune and type 1 diabetes susceptibility genes in blood from young children after COVID-19 infection Viral infections, including COVID-19, are associated with an increased risk for type 1 diabetes (T1D), but potential underlying mechanisms remain unex…

Tell me again how Cøvid is okay for kids 🤬🤬🤬💥

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www.sciencedirect.com/science/arti...

Faecal shedding is well described with many old lineages hanging around in immune compromised people.

Actually it's both. Just differing presentations.

I've been watching this since Carlo Brogna's group first published a suggestive article.

Frankly, I'm in his tent.

I think it's a bacteriophage. It explains much, but not everything about LC. Certainly a big reservoir.

More wonderful science from my amazing friends and colleagues ‼️

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portlandpress.com/biochemj/art...

‘If the hypothesis proposed, i.e., that under certain conditions SARS-CoV-2 may multiply at the expense of human gut bacteria, is further substantiated, it would drastically change the model of acting and infecting of SARS-CoV-2, and most likely that of other human pathogenic viruses.’

Evidence of SARS-CoV-2 bacteriophage potential in human gut microbiota In previous studies we have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in vitro in bacterial growth medium, that the viral replication follows bacterial growth,...

Cövid and your Gut.

Whilst still a contested space, its ability to act as a bacteriophage is increasingly important to note.

pmc.ncbi.nlm.nih.gov/articles/PMC...

Frontiers | Neuropsychiatric symptoms cluster as primary drivers of Long COVID complexity: a South Texas retrospective cohort study Long COVID, previously known as Post-Acute Sequelae of SARS-CoV-2 (PASC), refers to prolonged symptoms or diagnosable conditions following COVID-19 infection...

🧠 Daily Feed of Brain Damage 🧠

www.frontiersin.org/journals/neu...

FUCK Off

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The impact of acute COVID-19 symptoms on insomnia: A longitudinal study among medical students The COVID-19 pandemic has profoundly disrupted global mental health. Medical students, already vulnerable to high stress, experience heightened psycho…

Up your nose and into your prefrontal cortex.

The PFC is crucial for sleep initiation.

www.sciencedirect.com/science/arti...

Peripheral immune progression to long COVID is associated with mitochondrial gene transcription: A meta-analysis SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has led to millions of cases of Long COVID worldwide. Long COVID is a phenomenon characte…

Mitochondria and Long C-19.

www.sciencedirect.com/science/arti...

What you don't know will hurt you.

I would suggest you provide her with some science.

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

This paper should focus the mind‼️‼️

www.nature.com/articles/s41...

Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of Alzheimer’s disease-vulnerable regions | Journal of Clinical Sleep Medicine Study Objectives: Sleep deficiency is associated with Alzheimer’s disease (AD) pathogenesis. We examined the association of sleep architecture with anatomical features observed in AD: (1) atrophy of h...

Sleep studies in Long Covid are essential.

Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of Alzheimer’s disease-vulnerable regions | Journal of Clinical Sleep Medicine

jcsm.aasm.org/doi/10.5664/...

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Yeah....

It's a fucking irritation in many otherwise good science.

Cövid isn't good for anything...

bmjopen.bmj.com/content/15/7...

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😊🙏🏻

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Yep....

That's my people and our paper.

Awarded a prize from the Journal for the most read and download in 2024.

😂😂😂

UNSW was my Alma Mater... But access is through Sydney University

I have University of Sydney access...

Social Determinants of Health and Risk for Long COVID in the U.S. RECOVER-Adult Cohort | Annals of Internal Medicine Background: Social determinants of health (SDoH) contribute to disparities in SARS-CoV-2 infection, but their associations with long COVID are unknown. Objective: To determine associations between SDo...

Paywalled 🤬🤬

Poverty and LC aren't good friends 💔

www.acpjournals.org/doi/10.7326/...