Dr David Joffe MB BS(Hons), PhD, FRACP

Genome-wide DNA methylation profiling in COVID-19 positive patients reveals alterations in pathways linked to neurological dysfunction - Clinical Epigenetics Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible RNA betacoronavirus, causing coronavirus disease-19 (COVID-19). Infection with SARS-CoV-2 can result i...

🧠 Daily Feed of Brain Damage 🧠

link.springer.com/article/10.1...

ISLC-PAIS Conference 2026 in Amsterdam The ISLC-PAIS Conference brings together reseachers, clinicians and patient leaders working together to improve outcomes for people with Long COVID and other PAIS.

For those wanting the very best in Long C-19 Science‼️

💥 Registration opens very soon 💥

islc-pais.org

Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and comp... Objective M1 macrophage activation is crucial in chronic inflammatory diseases, yet its molecular mechanism is unclear. Results Our study showed that hemizygous deletion of the early autophagy gene at...

Complicated but really decent paper adding some additional context to PEMS.

Happy Saturday, Peeps 👋🏻👋🏻

doi.org/10.1007/s000...

She's a nasty vaneer of Anti-Vaxxer and Wellness Grifter wrapped in a sack of shit

Ondine's Curse is a form of Central Apnoea.

I mentioned that when we spoke Amanda. It can be brainstem related to stroke or inflammation. When patterned with periods of hyperventilation it's referred to as Cheyne-Stokes. Common in heart failure

Yep....

MRTB -> XRTB

Incoming

💥💥 Keeper 💥💥

😂😂 Breaks the Internet 😂😂

And the curtain has not even risen

🙏🏻👌🏻

🔥🔥👍🏻

I've become numb to this government.

Thankfully, we matter so little in a global sense... They could shutter parliament tomorrow and save us a fortune.

The "Art of Nothing"

The most secretive vacuous government on record...

Shitful on Climate Change and their adherence to " America First... Us second" is completely at odds with the people I see everyday, Steve

Please, Buddy...

You know how Albo Pty Ltd grates on me 🤬

Vote wasted!!

Everyday he pops on his Bradbury Award and choofs off to a photo-op. Fuck all policies or testicular fortitude... Four years later and still a spineless twat.

Gifted the majority by the timely self-emolation of the right

Those casualties are belly button fluff and merely fillers for the Celebrity shit rags...

A moment of grief... Then business as usual.

In reality, it's not deaths... We've become cynically immune to that.

It's crippling disability that will bring change

I think so 🧐🙏🏻

I'm pretty sure this isn't isolated to capitalist/fascists

This is a point of global stupidity. There are no sides in a Pandemic.

The virus gives no fucks.

No public holidays
No time in lieu
No affiliations
Doesn't vote

Spatial multiomics dissects the SARS-CoV-2-induced disruption of cell adhesion and immune dynamics in the human hippocampus - Journal of Neuroinflammation Journal of Neuroinflammation - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological complications, yet the underlying mechanisms remain poorly...

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The hippocampus 💀

link.springer.com/article/10.1...

Until there are casualties at the highest levels of power... Themselves or their nearest and dearest...

Until the mounting costs of disability and chronic health become unable to be conveniently dismissed??

No

We are still some time away from the inflexion point

The COVID generation: the neurodevelopmental consequences of in-utero COVID-19 exposure In historical viral epidemics, such as the H1N1 influenza and Zika viruses, prenatal exposures were correlated with risk for neuropsychiatric conditio…

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Cøvid in utero... Oh My Goodness 🤬

www.sciencedirect.com/science/arti...

Frontiers | Plasma proteomic profile reveals persistent immune activation in post-acute sequelae of SARS-CoV-2 infection Plasma proteomic profiling of 92 individuals with Post-Acute Sequelae of SARS-CoV-2 infection (PASC), assessed a mean of 34 months after acute infection, rev...

If you want to read one paper on Long C-19 today?

Make it this one 👍🏻

Plenty to unpack

www.frontiersin.org/journals/imm...

Assessment of dynamic cerebral blood flow changes during cognitive tasks in patients with post-COVID-19 syndrome Kutz et al. found that post-COVID-19 syndrome patients had altered cerebral blood flow, which was quantified using sample entropy (for temporal variability

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With thanks to @jencurtinmd.bsky.social

academic.oup.com/braincomms/a...

Post-MIS-C cardiovascular outcomes: a systematic review - European Journal of Pediatrics Limited knowledge and variability in findings exist regarding the resolution of cardiovascular outcomes following Multisystem Inflammatory Syndrome in Children (MIS-C). We conducted a systematic revie...

Post M-ISC.

Cardiac data.
Kids.

Looks can be deceived. Better? Not entirely

@atranscendedman.bsky.social 🙏🏻

link.springer.com/article/10.1...

😎🦾🦾

🧠 Daily Feed of Brain Damage 🧠

Part 2

doi.org/10.1016/j.bb...

🔥🔥Breaks the Internet today🔥🔥

Significant brain atrophy following new-onset refractory status epilepticus: A rare case of COVID-19 encephalitis The novel coronavirus (SARS-CoV-2) is a highly infectious respiratory virus with significant pathogenicity. Although its impact has lessened in many countries, its ongoing mutations and sporadic outbr...

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Levelling Up‼️

@atranscendedman.bsky.social 😳🙏🏻

www.cell.com/heliyon/full...

NSW parliament also has Far-UVC

I fear this will fall upon deaf ears.

If the Minister for Health cannot implement masks in hospitals and clinics, I sincerely doubt the Education Minister would be any better informed.

They don't care because it's not personally relevant to their entitled disconnected lives

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Now with metrics!

@atranscendedman.bsky.social 😎🙏🏻

doi.org/10.1038/s415...

😣🙏🏻