Patrick Reeves

Beyond excited to share our #NewPaper in @cellcellpress.bsky.social! Inflamed environments acidify intracellular #pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of #inflammation authors.elsevier.com/sd/article/S...

The actin-spectrin submembrane scaffold restricts endocytosis along proximal axons Clathrin-mediated endocytosis has characteristic features in neuronal dendrites and presynapses, but how membrane proteins are internalized along the axon shaft remains unclear. We focused on clathrin...

The big one is out! So over the moon to see our latest work with Stéphane Vassilopoulos published in Science. Check out how we reveal the unique architecture of clathrin-coated pits and endocytosis at the axon initial segment: www.science.org/doi/10.1126/...

The science being done in my lab right now is the best in my 20 years as a professor at UW. It's just incredible whiplash to flip between that the science funding situation here in the US, and to think about the societal abandonment of the brilliant young trainees who are pushing the work forward.

A systems immunology analysis of Alzheimer’s disease reveals an age- and environmental exposure-independent disturbance in B cell maturation Alzheimer’s disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinica...

Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social.

This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8

www.medrxiv.org/content/10.1...

The videos from the 8th Single-Cell Proteomics Conference (#SCP2025) will be joining this growing YouTube playlist.

www.youtube.com/playlist?lis...

🔬In this month's Editorial, we announce a cross-journal pilot at @natureportfolio.nature.com journals aiming to implement standardized light and fluorescence #microscopy reporting to improve methodological description and aid in #reproducibility efforts.
👉https://rdcu.be/esnOK

bit.ly/3TAzZIK

CD103+CD56+ ILCs are associated with an altered CD8+ T-cell profile within the tumour microenvironment Abstract. Immunotherapies have had unprecedented success in the treatment of multiple cancer types, albeit with variable response rates. Unravelling the complex network of immune cells within the tumo...

An exciting new paper from Pamela Ohashi, Hartland Jackson, et al, on CD103+CD56+ innate lymphoid cells in the tumor microenvironment.

aacrjournals.org/cancerimmuno...

#spatialbiology #TME #IMC #imagingmasscytometry @standardbiology.bsky.social #UHN_Research

OICR research highlight Segmentation aware probabilistic phenotyping of single-cell spatial protein expression data. Segmentation errors in multiplexed imaging makeit difficult to interpret single-cell expression profiles. This is an important existing limitation for spatial biology assays as well as the development of patient biomarkers. The research team introduce evaluation metrics, a gold-standard dataset, and a probabilistic machine learning method to tackle these issues. They showed that true single-cell expression profiles may be recovered from these tissues in the absence of additional prior knowledge. Published in Nature Communications, January 2025 Authors: Dr. Kieran Campbell OICR Associate Dr. Hartland Jackson OICR Investigator

⭐ OICR RESEARCH HIGHLIGHT ⭐

Check out this new research into multiplexed imaging by Drs. Kieran Campbell and Hartland Jackson that was recently published in Nature Communications.

@hartjackson.bsky.social @kieranrcampbell.bsky.social‬ @sinaihealth.bsky.social @uoft.bsky.social

I agree the thymus likely presents all key epitopes for T cell tolerance. But studies based only on transcriptional data without testing each mimetic cell’s role should be viewed cautiously and given lower priority.

#thymus
#tolerance
#immunology

Hey there,

Our latest paper is out in Cell.

We made a knockout collection in a human fungal pathogen, performed over 140 screens, and developed 6 follow up stories.

Phenotypic landscape of an invasive fungal pathogen reveals its unique biology

Share link:

authors.elsevier.com/c/1lFMiL7PXu...

Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade Blanchard et al. reveal that Fc-optimized anti-CTLA-4 antibodies remodel tumor vasculature and increase tumor-associated high endothelial venules (TA-HEVs) that support T cell recruitment into tumors....

'Here, we report that Fc-optimized anti-CTLA-4 antibodies are potent remodelers of tumor vasculature that increase tumor-associated high endothelial venules (TA-HEVs), specialized blood vessels supporting lymphocyte entry into tumors'
#Immunology #Immunotherapy
www.cell.com/cell-reports...

Today marks the 44th anniversary of the publication in the MMWR of a new syndrome that we now know as AIDS www.cdc.gov/mmwr/preview... (MMWR 1981;30:250--2). Much progress since then but much remains to be done.

"If the proposal is enacted, Americans today and tomorrow will be sicker, poorer, and die younger”
an $18 Billion cut
Only 3 NIH Institutes will remain in place, and even they will have their funds markedly reduced
www.statnews.com/2025/05/30/n...

1/5 We introduce Movi Color, led by Steven Tan (a brilliant undergrad member of Langmead lab) for taxonomic and multi-class classification. It uses a full-text index based on the move structure and does not rely on predefined values (like k-mer length) for index building.
github.com/mohsenzakeri...

IRF7 promotes lupus-prone germinal center and plasma cell responses by regulating transcriptome, translation, and metabolism of B cells @jem.org @spt-gc.bsky.social @adamfike.bsky.social
rupress.org/jem/article/...

I am very enthusiastic for improving fragmentation spectra & the research this empowers.

This means increasing the sensitive and scope of sequencing the immunopeptidome ==> better cell therapies.

biorxiv.org/content/10.1...
1/2

The biggest reason we don't actually have a "replication crisis" is that science is a process of advancing what's working, and not fixing what hasn't. Sometimes it's slow, and we backtrack a bit. But it's never stalled.

That said, the strain on scientific publishing is generating a lot of crap.

A posttranslational modification cycle specific for SMAD2 drives proinflammatory T cell development
www.science.org/doi/10.1126/...

Highly recommend if you want to work with a fantastic group of innovative, kind, and generally outstanding scientist

🧬 We're hiring - join our lab in Toronto, Canada! 🇨🇦

Exciting postdoc joint with @hartjackson.bsky.social developing machine learning methods for the next generation of spatial histopathology technologies joint with industry partners in the Bay Area.

👉 apply.interfolio.com/168307

Crimson Courage Crimson Courage is a growing community of Harvard alumni from all schools and decades united in standing up for academic freedom at Harvard and beyond.

New Harvard alum group formed to fight back and form alliances with other unis

See link about an online organizing event this week

www.crimsoncourage.com

“America First” Will Destroy U.S. Science The U.S. government has sought to restrict immigration under the “America First” doctrine. These policies severely harm American science by stripping it of talent and eliminating a major driver of its...

25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.

Postdoctoral studies in Immunology (scholarship) Do you want to contribute to top quality medical research?  The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, inf

Postdoc opening in Pia Dosenovic's lab at Karolinska Institutet, "B cell-mediated immunity with a focus on basic immunological questions related to vaccine development"
#Immunology #ScienceJobs #ImmunoSky

ki.varbi.com/what:job/job...

YouTube video by Amanpour and Company Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏

youtu.be/8YhJM6zxYDw?...

Humanity eradicated smallpox 45 years ago. It’s a story worth remembering | Aeon Videos Smallpox went from a feared killer to a fading memory. Its eradication is one of humanity’s greatest collective triumphs

'The US filmmaker Neil Halloran is known for short documentaries that combine illuminating data visualisation with powerful storytelling. In his latest work, The Plea, Halloran explores how smallpox went from perhaps the deadliest infectious disease in human history to a fading memory.'

I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too

mRNA-nanoparticle prime & heterologous boost drove early maturation (SHM) of HIV bnAb precursors in humans @science.org
www.science.org/doi/10.1126/...

What am I supposed to say to this generation of young scientists? Undermining the future of American science is not a path to accountability — it’s a path to decline.

The damage being done to the US scientific enterprise is massive.
"For young scientists, the impact of this crisis will ripple forward .... Some will leave science. Others will leave the country, searching for institutions that still believe in their future." www.statnews.com/2025/05/07/u...

This shot outperformed multiple existing, FDA-approved vaccines in a Phase 3 clinical trial in humans. But how will it perform against a saline injection? And how does it perform in mice?

This is figure 6, which shows the shared signatures of plasma proteome dysregulation associated with respiratory symptoms in healthy convalescent individuals and individuals with long COVID.

A study in Nature Immunology explores soluble biomarkers, immune cell subsets, viral antibody responses and plasma proteomics to better define and understand long COVID in two independent cohorts. go.nature.com/3GVktnC #medsky 🧪