Beyond excited to share our #NewPaper in @cellcellpress.bsky.social! Inflamed environments acidify intracellular #pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of #inflammation authors.elsevier.com/sd/article/S...
The big one is out! So over the moon to see our latest work with Stéphane Vassilopoulos published in Science. Check out how we reveal the unique architecture of clathrin-coated pits and endocytosis at the axon initial segment: www.science.org/doi/10.1126/...
The science being done in my lab right now is the best in my 20 years as a professor at UW. It's just incredible whiplash to flip between that the science funding situation here in the US, and to think about the societal abandonment of the brilliant young trainees who are pushing the work forward.
Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social.
This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
www.medrxiv.org/content/10.1...
The videos from the 8th Single-Cell Proteomics Conference (#SCP2025) will be joining this growing YouTube playlist.
www.youtube.com/playlist?lis...
🔬In this month's Editorial, we announce a cross-journal pilot at @natureportfolio.nature.com journals aiming to implement standardized light and fluorescence #microscopy reporting to improve methodological description and aid in #reproducibility efforts.
👉https://rdcu.be/esnOK
bit.ly/3TAzZIK
An exciting new paper from Pamela Ohashi, Hartland Jackson, et al, on CD103+CD56+ innate lymphoid cells in the tumor microenvironment.
aacrjournals.org/cancerimmuno...
#spatialbiology #TME #IMC #imagingmasscytometry @standardbiology.bsky.social #UHN_Research
⭐ OICR RESEARCH HIGHLIGHT ⭐
Check out this new research into multiplexed imaging by Drs. Kieran Campbell and Hartland Jackson that was recently published in Nature Communications.
@hartjackson.bsky.social @kieranrcampbell.bsky.social @sinaihealth.bsky.social @uoft.bsky.social
I agree the thymus likely presents all key epitopes for T cell tolerance. But studies based only on transcriptional data without testing each mimetic cell’s role should be viewed cautiously and given lower priority.
#thymus
#tolerance
#immunology
Hey there,
Our latest paper is out in Cell.
We made a knockout collection in a human fungal pathogen, performed over 140 screens, and developed 6 follow up stories.
Phenotypic landscape of an invasive fungal pathogen reveals its unique biology
Share link:
authors.elsevier.com/c/1lFMiL7PXu...
'Here, we report that Fc-optimized anti-CTLA-4 antibodies are potent remodelers of tumor vasculature that increase tumor-associated high endothelial venules (TA-HEVs), specialized blood vessels supporting lymphocyte entry into tumors'
#Immunology #Immunotherapy
www.cell.com/cell-reports...
Today marks the 44th anniversary of the publication in the MMWR of a new syndrome that we now know as AIDS www.cdc.gov/mmwr/preview... (MMWR 1981;30:250--2). Much progress since then but much remains to be done.
"If the proposal is enacted, Americans today and tomorrow will be sicker, poorer, and die younger”
an $18 Billion cut
Only 3 NIH Institutes will remain in place, and even they will have their funds markedly reduced
www.statnews.com/2025/05/30/n...
1/5 We introduce Movi Color, led by Steven Tan (a brilliant undergrad member of Langmead lab) for taxonomic and multi-class classification. It uses a full-text index based on the move structure and does not rely on predefined values (like k-mer length) for index building.
github.com/mohsenzakeri...
IRF7 promotes lupus-prone germinal center and plasma cell responses by regulating transcriptome, translation, and metabolism of B cells @jem.org @spt-gc.bsky.social @adamfike.bsky.social
rupress.org/jem/article/...
I am very enthusiastic for improving fragmentation spectra & the research this empowers.
This means increasing the sensitive and scope of sequencing the immunopeptidome ==> better cell therapies.
biorxiv.org/content/10.1...
1/2
The biggest reason we don't actually have a "replication crisis" is that science is a process of advancing what's working, and not fixing what hasn't. Sometimes it's slow, and we backtrack a bit. But it's never stalled.
That said, the strain on scientific publishing is generating a lot of crap.
A posttranslational modification cycle specific for SMAD2 drives proinflammatory T cell development
www.science.org/doi/10.1126/...
Highly recommend if you want to work with a fantastic group of innovative, kind, and generally outstanding scientist
🧬 We're hiring - join our lab in Toronto, Canada! 🇨🇦
Exciting postdoc joint with @hartjackson.bsky.social developing machine learning methods for the next generation of spatial histopathology technologies joint with industry partners in the Bay Area.
👉 apply.interfolio.com/168307
New Harvard alum group formed to fight back and form alliances with other unis
See link about an online organizing event this week
www.crimsoncourage.com
25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.
Postdoc opening in Pia Dosenovic's lab at Karolinska Institutet, "B cell-mediated immunity with a focus on basic immunological questions related to vaccine development"
#Immunology #ScienceJobs #ImmunoSky
ki.varbi.com/what:job/job...
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
'The US filmmaker Neil Halloran is known for short documentaries that combine illuminating data visualisation with powerful storytelling. In his latest work, The Plea, Halloran explores how smallpox went from perhaps the deadliest infectious disease in human history to a fading memory.'
I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too
mRNA-nanoparticle prime & heterologous boost drove early maturation (SHM) of HIV bnAb precursors in humans @science.org
www.science.org/doi/10.1126/...
The damage being done to the US scientific enterprise is massive.
"For young scientists, the impact of this crisis will ripple forward .... Some will leave science. Others will leave the country, searching for institutions that still believe in their future." www.statnews.com/2025/05/07/u...
This shot outperformed multiple existing, FDA-approved vaccines in a Phase 3 clinical trial in humans. But how will it perform against a saline injection? And how does it perform in mice?
A study in Nature Immunology explores soluble biomarkers, immune cell subsets, viral antibody responses and plasma proteomics to better define and understand long COVID in two independent cohorts. go.nature.com/3GVktnC #medsky 🧪
