Adrián Gómez Suárez

Halogen Bonding in Solution: Under Pressure The first study of the high-pressure behavior of organic halogen bond donors in solution is presented: HP-NMR titrations were performed in various solvents, primarily with a neutral tridentate halogen...

A paper with a Queen song title? Check! (Even though that was an easy one).
We've investigated the high pressure behavior of halogen bonding and found some unexpected solvent @solvationsci.bsky.social dependence:
pubs.acs.org/doi/10.1021/...

Author profile in Helvetica

Today is the 1st of August, National day of Switzerland and I am happy to share my profile author in @helvchimacta.bsky.social , as a part of their Early Career Board. Have a read if you want to know a bit more about me 😊 doi.org/10.1002/hlca... and happy 1st of August 🇨🇭

#PhDposition #OrganicChemistry #ChemBio - deadline 03.08 - please RT ❤️ Application online stellenangebote.uni-marburg.de/jobposting/d...

A postdoctoral position, funded by @leverhulme.ac.uk for up to 36 months, is available to join my group @edinburghchem.bsky.social. The project focuses on biomimetic approaches to natural product synthesis.

Deadline: 28th August 2025.

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

JOB ALERT! 🚨 Are you interested in organic synthesis and catalysis? We have an open PhD position in our group at Philipps-Universität Marburg in Germany. 👩‍🔬👨‍🔬 Deadline: 10th August 2025. For more details and to submit an application, please refer to the official posting here: lnkd.in/e_f3Xerq
#chemsky

Bridging the pyridine-pyridazine synthesis gap by skeletal editing Pairs of heterocycles differing by a single constitutive ring atom can exhibit stark differences in the retrosynthetic disconnections available for their preparation. Such a synthesis gap is exemplifi...

It’s pyridazine day at @science.org as two groups make double-N hexagonal rings! @levinchem.bsky.social and @mikusp.bsky.social do it by orchestrating an N-for-C swap in pyridines

chemsky 🧪

www.science.org/doi/10.1126/...

Meanwhile Hongjian Lu’s group insert nitrogen into 5-membered pyrrolidines

chemsky 🧪

www.science.org/doi/10.1126/...

Statistik der Chemiestudiengänge in Deutschland: Mehr internationale Studierende Das Chemiestudium in Deutschland genießt international einen ausgezeichneten Ruf. Im Jahr 2024 stammten rund 30 Prozent der Promotionsstudierenden aus dem Ausland. Auch die Zahl der ausländischen Stud...

gdch.app/article/stat...

Predictable C–H Functionalization of Complex <italic toggle="yes">beta</italic>-Fused Azines: A Mechanistically Bound Site-Specific Oxidation Direct manipulation of C–H bonds enclosed in complex scaffolds persists today as an elusive disconnection when aiming for high and predictable site-selectivity. Its development toward the late-stage d...

Check out this new direct #CHfunctionalization method for fused azines at #ACScentralscience : broad, metal-free and proceeding with exclusive and predictable #regiocontrol! Executed in #parallelmode for its immediate application to #drugdiscovery! 💊

pubs.acs.org/doi/10.1021/...

🚫 Current self-driving labs (SDLs) cost >$100K, blocking access for most researchers.

💡 Enter RoboChem-Flex: A fully modular, AI-driven lab for under €5K.

Built to democratize automation in chemistry. Open, affordable, and powerful.

🔗 chemrxiv.org/engage/chemr...

Our paper on the synthesis of >50 iodine reagents, and the systematic analysis of their electrochemical properties, is just out in Synthesis @synthesis1969.bsky.social 🤩

⚠️Full disclosure: this is my very first paper without transition metals! 😜 read it here: www.thieme-connect.com/products/ejo...

New @chemrxiv.bsky.social preprint!

RoboChem-Flex is a powerful, low-cost (<5k EUR), modular self-driving lab for chemical synthesis

We showcase 6 studies (photochemistry, biocatalysis, cross coupling, ee ...), all optimized with different configurations & ML

🔗 chemrxiv.org/engage/chemr...

Harnessing carbene polarity: Unified catalytic access to donor, neutral, and acceptor carbenes Metal carbenes are highly useful intermediates in organic synthesis. However, not all classes of carbene polarity are catalytically accessible, nor are there common precursors known to synthesize all ...

In @science.org this week, THE @nagiblab.bsky.social makes all the carbenes (no, seriously!) and classifies their electronic properties on a common basis

chemsky 🧪

www.science.org/doi/10.1126/...

Check out our latest contribution in
ChemElectroChem: a work on intensifying the electrochemical hydrocarboxylation of activated alkenes. Interesting findings regarding the impact of current density on reaction selectivity!

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Some Items of Interest to Process R&D Chemists and Engineers

Happy Items of Interest Day! The July issue of #OPRDItems is out today. Fantastic synth from academia & industry. Tons of strained rings in here and even #Mechanometallaphotoredox (say it 3 times fast). Great read for pharma & anyone interested in methodology or just good/usable chemistry #Chemsky

Congrats to Florian, Stone and Sam for publication of Part 1 in our collaboration with Laura Bohn's lab to explore the pharmacology of GB18, a Galbulimima alkaloid that we identified as a novel opioid in 2022.
pubs.acs.org/doi/10.1021/acscentsci.5c00573

Versatile Open-Source Photoreactor Architecture for Photocatalysis Across the Visible Spectrum Adoption of commercial photoreactors as standards for photocatalysis research could be limited by high cost. We report the development of the Wisconsin Photoreactor Platform (WPP), an open-source phot...

#chemsky, have you used a Wisconsin Photoreactor? I designed them and will soon defend my PhD. I’d like to include photos of Wisconsin Photoreactors in use by other chemists in my defense. Please share (reply to this post or DM me) a photo of your photoreactor in action!

doi.org/10.1021/acs....

Probing substrate binding and release events in iridium-catalysed hydrogen isotope exchange reactions Directed, metal-catalysed C–H activation reactions rely on the binding of a Lewis basic functional group to the metal centre to ensure precise control of regioselectivity. However, groups that bind th...

Daria's collaborative paper with Professor Billy Kerr and Dr Dave Lindsay was published today in @chemicalscience.rsc.org. This explores how many C-H deuteration events occur per binding event in iridium-catalysed hydrogen isotope exchange.

The article is open access: doi.org/10.1039/D5SC...

Research Position (PhD) in organic chemistry and b... <div style="text-align: justify;">The&nbsp; research&nbsp; group&nbsp; „Organic&nbsp; Chemistry&nbsp; and&nb...

Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)

Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group

uni-bielefeld.hr4you.org/job/view/433...

Accessing sulfonamides via formal SO2 insertion into C–N bonds - Nature Chemistry Despite recent advances in primary sulfonamide synthesis, approaches using primary amines as starting points for direct sulfonamide construction remain elusive. Now a formal SO2 insertion into the C–N...

Online today @natchem.nature.com - we show how to turn a deletion reaction into an insertion reaction:

www.nature.com/articles/s41...

We are hiring! 🔔📝 We have an opening for a new PhD student to join the group to harness photochemistry to make some new bridges bicycle motifs. Application deadline is the 10th July and applications should be sent to the email address given in the advert. www.uni-goettingen.de/de/644546.ht...

🦋RPC@BCB: Our work on strain-enabled radical-polar crossover annulation to access hetero-bicyclo[3.1.1]heptanes just out in @angewandtechemie.bsky.social . Thanks to @iiscbangalore and @ANRFIndia for the financial support.
🔗https://doi.org/10.1002/anie.202506747

Direct Pd-Catalyzed β-C(sp3)–H Hydroxylation of Aliphatic Carboxylic Acids β-Hydroxy carbonyl scaffolds are of paramount importance due to their presence in a variety of natural products and bioactive molecules. In this study, we present a direct palladium-catalyzed β-C(sp3)–H hydroxylation of aliphatic carboxylic acids. The reported method employs convenient and readily available TBHP as an oxidant and provides an efficient, one-step route to a diverse range of β-hydroxy acids. Key aspects include the compatibility of this method with challenging α-non-quaternary carboxylic acids as substrates and excellent functional group tolerance. This newly developed method is expected to prove useful for generating compound libraries relevant to multiple disciplines.

Five years after reporting the direct acyloxylation of carboxylic acids, we could now finally achieve the direct hydroxylation, just out in Org. Lett. Huge congratulations to @sourjyamal.bsky.social and Tianxiao Xu!
pubs.acs.org/doi/10.1021/...

New paper in #GreenChemistry!

We developed a recyclable ionic liquid photocatalyst based on decatungstate (DT-IL) 💡

✅ Easy synthesis ✅ Broad solvent compatibility
✅ 100× higher concentrations ✅ Fully recyclable

🔗 pubs.rsc.org/en/content/a...

#Photocatalysis #FlowChemistry

Free registration is now open for the Virtual @chembiotalks.bsky.social. We have an amazing program for you. Stay tuned for more information coming very soon!

One photon or two photons, that is the question. We discuss mechanistic challenges, pitfalls, and opportunities for future research in two-photon photocatalysis @angewandtechemie.bsky.social. Many thanks to first-authors Julian and Sophie.

onlinelibrary.wiley.com/doi/10.1002/...

Alternatives to Dichloromethane for Teaching Laboratories New US regulations restricting dichloromethane (DCM), also called methylene chloride, may prompt instructors of teaching laboratories to avoid its use entirely. This commentary addresses the hazards, ...

Yay! J. Chem. Educ. paper out on removing DCM from teaching labs! It was a delight to work with Dr. Vosburg and his students, especially because I graduated from Mudd, which is where David teaches now (he started the year after I graduated so we didn't overlap). pubs.acs.org/doi/10.1021/...

Development of an Organoautocatalyzed Double σ‐Bond C(sp2)‐N Transamination Metathesis Reaction Organoautocatalyzed transamination metathesis of cyclic tertiary amines is disclosed as a high-yielding, scalable reaction that proceeds under mild, catalyst-free conditions. It operates via a multi-....

Happy to share the final version of our paper! We report #waste-reducing, #cost-efficient synthesis of N-substituted #dihydropyridines. No catalysts or harsh reagents needed! #Organoautocatalysis #Transamination #GreenChem #AngewChem

#ChemSky #AcademicSky

onlinelibrary.wiley.com/doi/10.1002/...

Synthesis and Nucleophilic Ring-Opening of 1,1-Dicyanocyclopropanes: Accessing β-Aminocarbonyl Derivatives from Olefins We report an atom-transfer radical addition-ring closure sequence for the preparation of 1,1-dicyanocyclopropane electrophiles and demonstrate their nucleophilic ring-opening with alkyl amines under mild conditions. The resulting aminomalononitrile products were converted to complex β-aminocarbonyl derivatives in one pot under aerobic conditions.

Incredibly proud to finally see @sebastianuitbe.bsky.social first corresponding author paper online! Congrats to Jan (worked on this during MSc thesis) and Mohit for helping to get it done. I must say, I really enjoyed working on this paper!

pubs.acs.org/doi/10.1021/...