Anestis Tsakiridis

Developmental origins of paediatric cancer symposium A one-day event showcasing the latest cutting-edge research on the modelling, biology and treatment of paediatric cancers in the context of their developmental origins.

I am co-organising a @cclguk.bsky.social @dmmjournal.bsky.social symposium on the developmental origins of paediatric cancers at the @crick.ac.uk on 8/6/2026. Great speaker line up, affordable registration and available slots for short talks-spread the word! www.cclg.org.uk/information-...

Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency In primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associate...

Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells.

In a new preprint, we share some clues about when, how, and why this happens!

www.biorxiv.org/content/10.1...

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Neuroblastoma-associated ALK variants have distinct cellular and biochemical activities https://www.biorxiv.org/content/10.1101/2025.09.25.677354v1

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...

Targeting USP7-PRC1 axis as a novel therapeutic approach in drug resistant Diffuse Large B-Cell Lymphoma at Queen’s University Belfast on FindAPhD.com PhD Project - Targeting USP7-PRC1 axis as a novel therapeutic approach in drug resistant Diffuse Large B-Cell Lymphoma at Queen’s University Belfast, listed on FindAPhD.com

We have an exciting, fully funded PhD studentship (UK and ROI) to investigate mechanisms of epigenetic regulation in drug resistant B-cell lymphoma.

We are looking for a highly motivated, driven candidate to join our team.

eur02.safelinks.protection.outlook.com?url=https%3A...

I am advertising for a #postdoc for a 3 year BBSRC-funded project exploring the role of macrophages in salivary gland development. The successful candidate will be based at @edinuni-irr.bsky.social at @uni-of-edinburgh.bsky.social. Closing date: 9th Oct. elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

A 6-month postdoc position is currently available in our group. The project involves the use of hPSC-based models to dissect the links between chromosomal copy number alterations, DNA damage and tumour initiation-please spread the word-closing date=29th Sept: www.jobs.ac.uk/job/DON353/r...

I'm a bit late to the party over here. I'll be advertising a BBSRC-funded postdoc position soon. So if anyone wants to solve some outstanding questions in limb development - please get in touch. We have a variety of models and approaches (everything from stem cells to sharks). towerslab.weebly.com

NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinction | The EMBO Journal imageimageSOX2 and NANOG are core transcription factors governing pre-implantation pluripotency in the developing embryo. Here, extensive in vivo imaging and genetic analysis uncovers a novel post-imp...

Really nice work by @fredwck.bsky.social and the groups of Val Wilson and Ian Chambers (including a small contribution from me from my Edinburgh postdoc years) showing how pluripotency factors can temporally orchestrate both pluripotency and it extinction: www.embopress.org/doi/full/10....

Postdoctoral Research Associate: Modelling Neural Crest Anomalies (mouse/human) - the Node The Liu lab is looking for a postdoc with a love of embryos and developmental biology! This post is part of an MRC-funded collaboration between Karen Liu’s lab at King’s College London and Marco Trizz...

Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab @marcotrizzino.bsky.social modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills @the-node.bsky.social #developmental @ccrb27.bsky.social

thenode.biologists.com/jobs/postdoc...

Application deadline for up to 5 @mrc-lms.bsky.social postdoc positions in developmental epigenetics closes soon - don’t miss out! Positions across both experimental and computational projects. Come and join our fantastic team science community!

📣 Cilia Lab is growing 📣 - we have 2️⃣ open positions at @uoe-igc.bsky.social @edinburgh-uni.bsky.social for talented and motivated researchers interested in disease modelling & genetic therapies which target #RareRespiratoryDiseases at their root cause. 🧪🧪#ciliopathies #PrimaryCiliaryDyskinesia 1/4

Ecstatic to share our paper on nutrient signaling in the #EntericNervousSystem published in Nature! 🧪

We explored how neurons in the gut respond to basic nutrients that we typically ingest and tested whether they can distinguish between different nutrients 🔬

Check it out 👉 tinyurl.com/3vc756dv

Looking foward to the Northern(ish) Developmental Biology Meeting 2025 next week @sheffielduni.bsky.social! Thanks to the organisers @shaneherbert.bsky.social Raman Das @tsakiridis.bsky.social @kyracampbelllab.bsky.social

ENS aficionados, mark your calendars: the next symposium on enteric nervous system development, function and repair, will be held at KU Leuven from 7–10 April 2026. Excellent line up of speakers and the website is now live so for more details check: ens-leuven2026.eu ‪

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

Congrats Vicki!

Today’s speaker in our DRN external seminar series is Dr Sissy Wamaitha from the University of California, Los Angeles (UCLA)

Sponsored by the Physiological Society @physoc.bsky.social

Host: Stan Strawbridge
@stanleystrawbridge.bsky.social

All welcome!

🚨 New paper out in Development! 🚨

We show that donor embryonic stem cells (ESCs) reshape the developing mouse embryo, not just by what they signal, but where they push.

📄 doi.org/10.1242/dev....

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1/10🧵 New preprint! 🚀
We built a resource of 20 clonal human naïve pluripotent stem cell lines from 10 blastocysts. Explore embryo-to-embryo and clone-to-clone variation in one place.
👉doi.org/10.1101/2025.06.02.657331

We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.

Today’s speaker in our DRN external seminar series is Dr Thorsten Boroviak (PDN, University of Cambridge) @pdncambridge.bsky.social , who will talk on early embryonic development in primates.

Host: Anestis Tsakiridis @tsakiridis.bsky.social

All welcome!

Congratulations to Dr Claire Turner @molmicrosheffield.bsky.social and DRN's Professor Ivana Barbaric on their excellent talks in the University of Sheffield @sheffielduni.bsky.social School of Biosciences Inaugural Lecture series today.

www.sheffield.ac.uk/biosciences/...

www.thebarbariclab.com

The UK Stem Cell Network has just launched registrations for the meeting in September: Find out more by visiting ukstemcellnetwork.org/2025-confere...

Early-bird deadline is 23rd June

Indeed, it was great to catch up again!

Fantastic to see @tsakiridis.bsky.social's excellent work on Neuroblastoma and to finally chat some science with a social acquaintance from my PhD years some 20 years later 😮

Such a pleasure to host you for the @uoe-igc.bsky.social seminar series @tsakiridis.bsky.social. It was great to hear about your latest exciting and impactful science and it was great to catch up! Thank you for visiting us and bringing the beautiful weather!

This is insane. Labour is making the very same mistake the Tories made but in a more catastrophic way. A left-leaning party adopting an ultra-right fascist agenda: what could go wrong?

Always a pleasure to return to Edinburgh and visit @uoe-igc.bsky.social, I had a fantastic day discussing science and meeting old and new friends. Many thanks to @hannahlong.bsky.social for the warm hospitality-even the sky was blue!