Xavier Graña Lab

Here we are, happy to join the community!

Doctors Thought They Knew What a Genetic Disease Is. They Were Wrong. Mutations that happen throughout a person’s life may contribute to disease more than we realized.

OK I am annoyed by these misleading science graphics

swiping a sequencing gel up and down?
playing a few frames of a timelapse movie ad nauseam?

nothing is explained
everything is 'spooky' and 'weird'

it all reflects the easy seduction of scientific illiteracy

I can’t wait for 1-800-ALPHAFOLD wher eyou can just shout “Siri: Met-Asp-Arg…” and it will fold for you 🤣

Download our database of 313 different postdoctoral fellowships.

For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).

Download our database here: research.jhu.edu/rdt/funding-...

A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase https://www.biorxiv.org/content/10.1101/2024.07.23.604754v1 Serine-threonine phosphatases have been challenging to study because of the lack of specific inhibit

A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase https://www.biorxiv.org/content/10.1101/2024.07.23.604754v1

The PNUTS phosphatase complex controls transcription pause release Kelley et al. discover that the PNUTS phosphatase complex plays an essential role in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves this through its TND, which recog...

Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)

bsky.app/profile/did:...

Users working on #phosphatases. Keep up to date with all posts from the community. If you want adding/removing let me know. If you can't decide whether you should be included, then ask yourself - would I go to a phosphatase meeting in person? If yes, then sign up!
bsky.app/profile/did:...

Understanding the origin of eukaryotic cells is one of the biggest puzzles in biology 🧩 As genomic data expand, painting a clear picture of LECA requires analytical resources and a commitment to data sharing. This paper led by T. R. emphasizes a community-driven approach to tackle this complexity.

🎨 In case anyone need…

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!

Check it out 👇
bioart.niaid.nih.gov

Bluesky Starter Packs - Bluesky Directory Browse a list of Bluesky Starter Packs. Discover and connect with your community on Bluesky

Did you know there’s a site to search for starter packs of people to follow? Built by @mubashariqbal.com

blueskydirectory.com/starter-pack...

Like ‘old Twitter’: The scientific community finds a new home on Bluesky After recent changes to Elon Musk’s X, a gradual migration turns into a stampede

“Like ‘old Twitter’: The scientific community finds a new home on @bsky.app

Commentary in #Science

www.science.org/content/arti...

"Dark TFs": new manuscript mapped 166 uncharacterized human transcription factors, finding half bind genomic "dark matter," often closed chromatin rich in transposable elements.
www.biorxiv.org/content/10.1...

Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment - Nature Reviews Molecular Cell Biology In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific recruitment of enzymes to the plasma membrane, exploiting the cell cycle’s natura...

Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment.

Nice review #mitosis #CellCycle

www.nature.com/articles/s41...

This is great thanks!

A list of people interested in cell cycle entry and exit. Reply to this post if you want to be added. #senescence #cellcycle

go.bsky.app/7hEivbt

Looking to expand this group if you can help spread the word or add anyone I missed… @alexisbarr.bsky.social @dnatarheel.bsky.social @purvislab.bsky.social

Tough to abandon Twitter (can’t bring myself to call it “X”), but the time is well past.

Sky Follower Bridge Instantly find and follow the same users from your 𝕏 followers on Bluesky

Hi, I started moving from X. I used www.sky-follower-bridge.dev. It help me find about 20% of the people who I was following on X. Thanks, Adrian.