Nilsson lab

287m USD - you could support a reasonable number of projects with that money.......

That is a lot of cash burned! Looks like the only thing they are moving forward with is a molecule that makes beta-catenin form condensates. This seems completely opposite to the vision statement of the company

CRISPR screening season before holiday season

PhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute. The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR

I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...

Polo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidy Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains i…

Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social

www.sciencedirect.com/science/arti...

congrats Carlos and team - pleasure to work with you as always

Black and white portrait of John Gurdon, 1971

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews

Arrived in Wurzburg to get the latest om phosphatases!

Nice. Intriguing with UBE2C - would think the protein is unstable so you would slow down APC/C and prolong arrest.

Returning from two great days at ICR in London to visit Norman Davey and many others. Need 20 days next time!

The @embo.org #chromoploidy2025 is over. It was an amazing workshop organized by a perfect match of scientists and friends @mcclellandlab.bsky.social @bendavidlab.bsky.social @stesantaguida.bsky.social @foijer-lab.bsky.social, Elsa Logarinho, Caroline Audouin and myself

Here we go - 4 days of excellent science in Italy

Back again TOMORROW (Thursday April 3rd) for another IDPSeminars!

Noon central time - sign up for the webinar here
forms.gle/3yCHeYvuuqLh...

Phosphatases: from basic research to translation Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…

Come join us for the phosphatase meeting this summer! Deadline approaching for signing up for this great meeting.
meetings.embo.org/event/25-pho...

this is crazy!

MSK also under DOGE investigations? I thought you would be safe. Hope to see you in Italy

In addition to uncovering CYB5R4 our functional map hints at many additional regulatory pathways and mechanisms that can now be explored by the community. Thanks to Norman Davey this will be facilitated through a website allowing exploration of the base editor screens slim.icr.ac.uk/base_editing...

We find that CYB5R4 mediated activation of PP4 is critical for controlling the response to the DNA damaging agents cisplatin and Illudin S that cause elevated levels of ROS. This extends earlier important observations from the @durocher1.bsky.social lab on CYB5R4 (Olivieri et al 2020).

We uncover CYB5R4 as an activator of PP4 and PP6 but not the closely related PP2A. CYB5R4 is a dedicated reductase for the catalytic metal ions and we show that this pathway is conserved from yeast to man. Thus PP4 and PP6 activity is regulated by oxidation and reduction of the metal ions.

A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions Serine/Threonine phosphoprotein phosphatases (PPPs, PP1-PP7) are conserved metalloenzymes and central to intracellular signaling in eukaryotes, but the details of their regulation is poorly understood...

Happy to share our latest work on phosphoprotein phosphatase (PPP) regulation. We integrate CRISPR knockout and focused base editor screens to uncover the regulatory landscape of PPPs (more below). Great collaboration with the Zhu, Davey, Kettenbach and Ogris labs.
www.biorxiv.org/content/10.1...

Opinion | American Science is Under Attack (Gift Article) The Trump administration hobbles research and endangers the public health.

www.nytimes.com/2025/02/14/o...

An eloquent defense of American science by Harold Varmus, a Nobel Prize winning scientist during his days at UCSF, former director of the NIH and NCI, and former President of Memorial Sloan Kettering Cancer Center (full disclosure — it’s where I work)

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC) The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

Goodbye to my office for the last 14 years. Time to pack down and head for new adventures

Congratulations to @andibrunner.bsky.social
and the team, and many thanks to the lab of Jan-Michael Peters for support!

We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:

In both stages big loops are built first, small ones second

Functional profiling of serine, threonine and tyrosine sites - Nature Chemical Biology The use of an adenine base editor enables identification of functional serine, threonine and tyrosine residues that impact cell fitness on a genome-wide scale with possible involvement in phosphorylat...

Interesting read - large scale base editor screen to probe S,T and Y function in RPE1 cells.
www.nature.com/articles/s41...

Postdoc of molecular data science

Want to come work with me? Short postdoc opportunity. Deadline tomorrow ⚡️ jobportal.ku.dk/videnskabeli...

POLO kinase inhibits Protein Phosphatase 1 to promote the Spindle Assembly Checkpoint and prevent aneuploidy Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains ill-defined. Here, we demonstrate in vitro and in D...

Just in time for Christmas. Latest from the lab www.biorxiv.org/content/10.1... great collaborative effort with @nilssonlab.bsky.social @andrea-musacchio.bsky.social and Mathieu Bollen.

Phosphatases: from basic research to translation Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…

In case you still haven't found the perfect Xmas present:
meetings.embo.org/event/25-pho...

Lad xmas party - merry xmas to everyone!