VGLUT2 in Parkinson’s disease: an emerging therapeutic target Parkinson’s disease is among the most common age-related neurodegenerative disorders today and characterized by midbrain dopamine neuron degeneration. However, this cell loss is not uniform. Though...

Excited to share a new paper with #EmilyRocha and #MaryTorregrossa on mechanisms of #dopamine neuron resilience in #Parkinson's disease! We discuss the therapeutic potential of targeting the vesicular glutamate transporter 2, VGLUT2, to boost neuroprotection.

www.tandfonline.com/doi/10.1080/...

Ultimately, this workflow can be applied to not only examine spatiotemporal actions of drugs of abuse on neuronal activity across the brain, but also mapping neuronal activity more generally.

We identified distinct patterns of morphine-induced regional brain activation across both time and sex, highlighting key regional and sex differences in opioid actions.

This workflow enabled us to comprehensively characterize the global anatomical expression patterns of the cellular activity marker gene c-Fos in response to the opioid morphine.

Excited to share new work with the labs of #AlanWatson #RyanLogan and led by #IanaVasylieva #ReeseSmith with amazing collaborators in @commsbio.nature.com!
We developed a whole brain imaging and analysis workflow which we applied to study opioid actions across brain.
www.nature.com/articles/s42...

TANGO: Analysis and curation of particles in cryo-electron tomography - Nature Communications Cryo-electron tomography visualizes molecules inside cells, but it lacks flexible tools to study their spatial organization. The authors present TANGO, a framework that utilizes neighborhoods of parti...

Today in #journalclub we learned that it takes two to TANGO: particle lists and spatial analysis! 💃🕺 Check out this new open-source Python package that lets you get more information from your cryo-ET data.
www.nature.com/articles/s41...

The NIH Summer Internship Program (SIP) will open on 12/8 to accept applications from students studying biology, engineering, epidemiology, psychology, math, chemistry, pharmaceutical sciences, nursing, physics, computer science, bioinformatics, and health-related fields #chemsummer

Dr. Zoe Donaldson — Stories of WiN studies the neural circuits that govern social bonding and social loss, and how variations in these circuits shape emotional outcomes

Our latest profile is here! Dr. Zoe Donaldson (@neurozoe.bsky.social) studies the neural circuits that govern social bonding & social loss, and how variations in these circuits shape emotional outcomes.

Follow the link to listen! #StoriesOfWiN #WomenInNeuroscience

storiesofwin.org/profiles/202...

We are pleased to announce Doppio version 1.4! Available here www.ccpem.ac.uk/software/dow...

Excited about a new paper by the amazing #EvaMartinSolana #SoniaFrendi #JiyingNing #TabithaBanksTibbs and #JerryVockley where we offer a step-by-step protocol for preparing cells for #cryo-electron tomography!
#TeamTomo
onlinelibrary.wiley.com/share/author...

The Giant Synapse Symposium - a free, one-day event focused on synaptic function - will place on Nov. 14th, the day before the start of SFN: shorturl.at/AwLqE. Please consider attending or spreading the word.

Fellowships & Early Career Awards Awarded to encourage young scientists, clinicians and students to devote their talents to the study of PD.

⏰The clock is ticking to get your LOI submitted for the
2026 Parkinson's Foundation Postdoctoral Fellowship! Applications close Wednesday, 10/22 at 3:00pm 😱

For more information and to apply, please visit: www.parkinson.org/advancing-re...

Senior Director - Scientific Officer Primary Work Address: 4000 Jones Bridge Road, Chevy Chase, MD, 20815 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the disco...

Great Job - Great Colleagues - Great Science👍
Help us pick the next generation of @hhmi.org Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows
Relocation to DC is required, perfect for academic PIs looking for their next chapter
hhmi.wd1.myworkdayjobs.com/External/job...

Awards for Independent Investigators Awards for independent investigators that we offer to advance Parkinson's research.

Our Impact Award LOI applications close THIS FRIDAY at 3:00pm Eastern! 😮 For more information and to apply, please visit: www.parkinson.org/advancing-re...

@parkinsondotorg.bsky.social

Antipsychotic Drugs and Dysregulated Glucose Homeostasis This systematic review and meta-analysis examines the association between antipsychotic drug use and glucose homeostasis while considering weight gain propensity, medication type, and treatment durati...

Antipsychotic Drugs and Dysregulated Glucose Homeostasis

#psychiatry #metabolism #drug-response #antipsychotics 🧪

jamanetwork.com/journals/jam...

Applications are now open for our UMMC Graduate Program in Neuroscience! Join a dynamic and collaborative environment where students work at the forefront of neuroscience—from molecules to behavior. 🧬🧠✨Application deadline: December 15. Apply here! lnkd.in/eSe2rwG

The RNAscope image shows expression of the gene encoding the dopamine transporter in the brain of a fly that had butyrate supplemented in its diet.

The new issue of #ScienceSignaling is out!

A study of fruit flies shows a common gut bacterium can enhance the rewarding properties of amphetamines, researchers uncover how proteins in extracellular vesicles can offer clues to HIV blockade, and more. https://scim.ag/45Up9V6

⚠️ART. "Fármacos antipsicóticos y homeostasis de glucosa desregulada
Una revisión sistemática y un metaanálisis"¿Existe una asociación entre el uso de fármacos antipsicóticos (FA) y las alteraciones de la homeostasis de la #glucosa? ➡️https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2837755

Antipsychotic Drugs and Dysregulated Glucose Homeostasis This systematic review and meta-analysis examines the association between antipsychotic drug use and glucose homeostasis while considering weight gain propensity, medication type, and treatment durati...

Exposición a antipsicóticos altera la homeostasis de la glucosa independientemente del tiempo de exposición, dosis, diagnóstico y propensión al aumento del peso #antipsychotics #glucose jamanetwork.com/journals/jam...

We hope that these findings will increase awareness of antipsychotic drug-induced dysregulations in glucose homeostasis alongside ongoing metabolic monitoring and potential treatment.

This is the largest systematic review to date examining disruptions in glycemic control associated with #antipsychotic drugs. We show that that antipsychotic drug treatment significantly disrupts glucose homeostasis independent of exposure time, dose, diagnosis, and weight gain.

Antipsychotic Drugs and Dysregulated Glucose Homeostasis This systematic review and meta-analysis examines the association between antipsychotic drug use and glucose homeostasis while considering weight gain propensity, medication type, and treatment durati...

Excited to share new work with #Margaret_Hahn #Emily_Smith #Mahavir_Agarwal #Christoph_Correll and collaborators. @jamapsychiatry.com
jamanetwork.com/journals/jam...

Thrilled to be part of an exciting new paper detailing work of the #Ernst_Strüngmann_Forum on #metabolic_neuropsychiatry providing new perspectives on roles of metabolism in brain and body and their therapeutic potential in #psychiatry
@ymilaneschi.bsky.social
t.co/CqsSNCPg4c

In May 2024, I joined an inspiring week at the Ernst Strüngmann Forum on #Metabolic #Neuropsychiatry.

Our first outcome is now in Nature Mental Health:
🧠 A Perspective on energy metabolism in psychiatric disorders
🔗 www.nature.com/articles/s44...

More to come in an upcoming volume—stay tuned!

Volume electron microscopy reveals 3D synaptic nanoarchitecture in postmortem human prefrontal cortex Neuroscience

Excited about our collaboration with #JillGlausier @thermofishersci.bsky.social and colleagues establishing volume electron microscopy approaches to map 3D synaptic nanoarchitecture in postmortem human prefrontal cortex in nanometer detail!
@cp-iscience.bsky.social
www.cell.com/iscience/ful...

We were honored to attend the 2025 Parkinson’s Disease Gordon Conference in Waterville Valley, NH. It was wonderful to bring together some of the best and brightest scientists to discuss the most exciting developments in PD research, including many of our own awardees and SAB members!

Symposia submissions for #Dopamine2026 conference have been extended. You now have until Monday June 23rd to submit your abstract. dopaminesociety.org/abstract-sub...

Investigating the Polygenic Relationship Between Cannabis Use and Schizophrenia in the All of Us Research Program Objective Decades of research have identified a strong association between heavy cannabis use and schizophrenia, with evidence of correlated genetic factors. However, many studies on the genetic relat...

Excited to share another piece of the chicken-or-egg puzzle: Investigating the Polygenic Relationship Between Cannabis Use and Schizophrenia in the All of Us Research Program
www.medrxiv.org/content/10.1...

Hello bluesky people from the Collaborative Computational Project for Electron cryo-Microscopy!

In this new study, we discovered sex-specific and regional differences in mitochondrial generation of cytotoxic reactive oxygen species and their relevance to dopamine neuron resilience.