Oscar Marcelo Lazo

Random chat last night...

— Dad, I'm not vaccinating. They say the HPV vaccine is the most painful one!
— Do you know what a papilloma is?
— No...
— A cause of cancer
— x___x
— A type of cancer that use to cause a lot of trouble and now you can avoid just getting vaccinated.
— Ok

Tengo que hacer algunas clases este semestre. Afortunadamente son algunas de las cosas que más me entusiasman en el mundo, así que simplemente espero poder transferir algo de ese mismo entusiasmo.

¡Se viene el segundo semestre!

I've been culturing intact explants of embryonic mouse basal forebrain. It's a pretty cool way to model interactions between the different BFN populations in vitro, both in physiology and disease, specially in Alzheimer's where these neurons are particularly vulnerable.

[Confocal— DAPI+Phalloidin]

This Thursday 31st/July at 3.30 pm we have another session of our Journal Club on Psychology and Neuroscience. This month we are led by Prof. @pauladagnino.bsky.social to discuss mental health outcomes monitoring in the public system.

Join us!

Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons https://www.biorxiv.org/content/10.1101/2025.07.15.664857v1

For Epistemic Respect – Against Reviewer 2 - Impact of Social Sciences Gorgi Krlev & Andre Spicer draw on an encounter with reviewer 2 and the subsequent twitterstorm, to explain what epistemic respect means and how to uphold it.

I came across this concept today and I liked this blog post on epistemic respect and peer-review: blogs.lse.ac.uk/impactofsoci...

Coming to London on a summer Saturday—when Pride celebrations were in full swing, and everyone was out with friends in all sorts of playful attire—has been absolutely vivifying!

Tomorrow!

I grew up one little bit today.

I'm going back to the lab in London in a couple of weeks, and instead of booking a bed in a noisy backpackers' hostel as usual, I evolved to booking myself a room in a proper family-run hotel next door.

Yeahp... getting old.

🙏 to editor Sian Lewis for this @natrevneuro.nature.com highlight on our recent paper

www.nature.com/articles/s41...

Today, in news that surprise no one...

www.nature.com/articles/d41...

Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series The findings suggest the safety and possible efficacy of jacifusen for treating FUS-ALS. The efficacy of jacifusen is being further evaluated in an ongoing clinical trial.

True that the promising story about jacifusen still requires more data to weight its impact in the real world, but I can't help thinking about the 16-y.o. kid with ALS that after a year of treatment is breathing again and recovering movement. Unprecedented progress! www.thelancet.com/journals/lan...

I feel you. I hope you comprehend.

😂 Qué talento.

If I were an elected Dem today, here’s what I’d be doing:

- Not cooperating with anything administration wants to do. No bailing the GOP out. Shut it down.

- Daily fireside chats explaining how/why I’m fighting.

- Calling them fash.

- Attending protests. Calling for protests (at their homes?)

Actually, if I go higher up the nih.gov website doesn't work either. :/

Works for me, but the main domain of the NCBI doesn't:

Asunto aparte es el declive de @theclinic.cl desde que fue adquirido por sus nuevos propietarios. Francamente triste. Ya nada es lo que era.

Post transplataforma desde LinkedIn sobre los traspasos de capital de CORFO a las arcas fiscales, a propósito de un excelente comentario de Eduardo Bitrán: www.linkedin.com/posts/omlazo...

Corrected, just because it was a small molecule and not ASO. Equally transformative step forward!

bsky.app/profile/omla...

First splicing therapy in utero for spinal motor atrophy (SMA). Massive achievement.

True! My mistake. I assumed it was an ASO but when I went to the paper I realised it was a small molecule. Thanks for noting it!

(I always wonder if these tiny compounds are really as specific as we want them to be)

Intracellular Trafficking SNARE Protein, Syntaxin-6, is a Modifier of Prion and Tau Pathogenesis in vivo and in Cellular Models https://www.biorxiv.org/content/10.1101/2025.02.19.635172v1

About to repeat the classic stories of cobras in Delhi and rats in Hanoi.

People will breed mosquitoes for cash.

Got baked beans from England just to pair them with Chilean merluza austral.

Coordination between ESCRT function and Rab conversion during endosome maturation | The EMBO Journal imageimageEarly endosome maturation requires Rab conversion and ESCRT function; however, how these processes are coordinated remains largely elusive. This study proposes that Rab conversion in both C....

Interested how events are coordinated during #endosome maturation? Check out our latest paper! Congrats Daniel, Samit and Jachen!
www.embopress.org/doi/full/10....

“Out of office” message put on. Limited connectivity, minimal meetings, sun, family and fresh air. 😌 Also time to read and plan for the future.

Todo indica que voy en el mismo vuelo que Dua Lipa. 😱