Christian Heckmann

Beautiful cover art by @allisonwolder.bsky.social

Transaminase‐Triggered Cascades for the Synthesis and Dynamic Kinetic Resolution of Chiral N‐Heterocycles A single-step biocatalytic route to complex indolizidine and quinolizidine alkaloids is described that relies on transaminase-triggered double intramolecular aza-Michael methodology. In one case, a r...

Controlling five stereocentres in one go😎 Extremely excited to finally share our work from the O’Reilly group in UCD on the assembly of chiral heterocycles via a DKR cascade🙌🏻
doi.org/10.1002/anie...
#chemistry #biocatalysis #catalysis #synthesis

NextGenBiocat Visit the post for more.

Are you an early career researcher in #biocatalysis? Do you want to showcase your work to your peers? The deadline to submit an abstract for an oral presentation at #NextGenBiocat is this Sunday ⏰️. Go to nextgenbiocat.org to register.

NextGenBiocat Visit the post for more.

Are you a #youngresearcher working in #biocatalysis? Do you want to share your work with #internationalscientists? Come to the #nextgenbiocat 8-9 of May in Milan! For more details on deadlines for abstract submission and how to register, see nextgenbiocat.org

Asymmetric Enantio-Complementary Synthesis of Thioethers via Ene-Reductase Catalysed C-C bond formation Enzymes are attractive catalysts due to their high chemo-, regio-, and enantio-selectivity. In recent years the application of enzymes in organic synthesis has expanded dramatically, especially for th...

Pleased to share our pre-print on using ene reductases to synthesise chiral thioethers: doi.org/10.26434/che...