@mayerlab.bsky.social
Associate Professor for Molecular Evolution at the University of Groningen. My group makes biomolecules to order by letting millions of them compete until a winner is crowned :) Sometimes it even works!
🥳🥳🥳 Our study on engineering enzymes to break C–F bonds is out in @angewandtechemie.bsky.social. Congrats to the brilliant & dedicated @suzannejansen.bsky.social for taking this step toward the remediation of #PFAS & other contaminating organofluorides!
onlinelibrary.wiley.com/doi/10.1002/...
📢 📢 📢 !!!Come and join us!! 📢 📢 📢
We are looking for a Postdoctoral Researcher with in-depth experience in next- and third-generation sequencing to help us understand the fitness landscapes of complex biomolecules! Please spread the word :)
werkenbij.rug.nl/vacature/pos...
Is today the day for phosphoramidite chemistry and/or next-gen sequencing??? #nobel #chemistry
08.10.2025 05:09 — 👍 0 🔁 0 💬 1 📌 0Was great seeing you again :)
16.09.2025 16:47 — 👍 1 🔁 0 💬 0 📌 0
Preprint alert! With #PFAS contamination becoming an environmental crisis, we dared to engineer natural defluorinases towards degradation of (un)natural organofluorides. How? Check out our robust growth-based selection platform here: www.biorxiv.org/content/10.1... thanks to @mayerlab.bsky.social !
17.07.2025 09:38 — 👍 10 🔁 5 💬 0 📌 0Overall, our study presents the first large-scale engineering campaign of FAcDs and introduces an operationally simple selection platform that paves the way toward adapting these enzymes for the sustainable degradation of contaminating organofluorides. (5/5)
17.07.2025 08:51 — 👍 0 🔁 0 💬 0 📌 0Forcing populations of bacteria expressing tens of thousands of distinct FAcD-variants to utilize various organofluorides as sole carbon source, we elicited a panel of FAcD variants with improved activities and drastically altered substrate profiles. (4/5)
17.07.2025 08:51 — 👍 0 🔁 0 💬 1 📌 0To expand the substrate scope of FAcDs for non-natural organofluorides, we designed and applied a robust growth-based selection, in which the FAcD-catalyzed C—F bond cleavage of synthetic organofluorides generates metabolizable C-sources. (3/5)
17.07.2025 08:51 — 👍 0 🔁 0 💬 1 📌 0While tailored biocatalysts able to cleave C—F bonds represent an attractive strategy to remediate organofluorides, Nature is largely agnostic to C—F bonds. Fluoroacetate dehalogenases (FAcDs) stands out by promoting the hydrolysis of single C—F bonds in fluoroacetate at high turnover rates. (2/5)
17.07.2025 08:51 — 👍 0 🔁 0 💬 1 📌 0
With #PFAS and other organofluorides wreaking havoc, we set out to engineer natural defluorinases for man-made organofluorides. All credit goes to the amazing @suzannejansen.bsky.social, who has outdone herself in this project! (1/5)
www.biorxiv.org/content/10.1...
In our recent publication, we describe a systematic framework leveraging the documentation of the quantum chemistry suite ORCA for developing large language models that are capable of providing input files based on user prompts with the help of prompt engineering, retrieval-augmented generation […]
11.02.2025 18:22 — 👍 11 🔁 5 💬 0 📌 0
Two weeks ago, we had a great group outing, including a city tour through Utrecht, a Mario Kart Wii tournament, and some Rock Band Wii fun! I am truly privileged to work with such a group of talented, dedicated, and smart individuals.
11.02.2025 19:55 — 👍 6 🔁 0 💬 0 📌 1Hello world, hello BlueSky 🙂
11.02.2025 16:09 — 👍 14 🔁 4 💬 2 📌 0
