@pbleic.bsky.social
MD/PhD, Academia => Biotech => Pharma/HealthIT => PE/VC. Immunology, medicine,dermatology, clinical trials, EDC, RWE, AI
Protests against Israel started en masse with marches in the streets of major cities on October EIGHTH - literally the DAY AFTER the Oct. 7th attack, before Israel had done anything but defend its citizens and secure its border with Gaza.
18.10.2025 20:24 β π 0 π 0 π¬ 2 π 0Ophthalmologist. Not optometrist. Trained at Duke Medical School.
19.09.2025 00:32 β π 1 π 0 π¬ 1 π 0It is shocking how many confounded and poorly done observational studies are published and widely publicized, leading to premature or incorrect conclusions by physicians and the public alike. At OptumLabs, we worked on methodology to blind and standardized the conduct and analysis of RWD.
02.09.2025 10:15 β π 1 π 0 π¬ 0 π 0Heβs not alone.
www.nytimes.com/2025/08/16/m...
You are not the first to notice!
30.08.2025 15:19 β π 1 π 0 π¬ 1 π 0And beyond.
21.08.2025 03:27 β π 0 π 0 π¬ 0 π 0Even earlier.
21.08.2025 03:25 β π 1 π 0 π¬ 0 π 0Share your outrage and other emotions. But reading comprehension. The 2 yo did not die. She had a miscarriage.
16.08.2025 11:37 β π 0 π 0 π¬ 1 π 0Happening all over the country. When an expensive drug becomes widely used, price is no longer about making up research costs for that and other failed drugs. It is about excess profits, and demands a substantial price drop.
15.08.2025 14:18 β π 2 π 0 π¬ 0 π 0βIt was the best of times, it was the worst of timesβ
14.08.2025 13:06 β π 1 π 0 π¬ 0 π 0I dare you. Read the plot. Comment and tell me what you think.
en.wikipedia.org/wiki/It_Can%...
1935 novel by Sinclair Lewis
Ditto Strep pneumonia. Bacterial, not viral. Herd immunity is irrelevant.
10.08.2025 21:10 β π 2 π 0 π¬ 0 π 0This list is NOT a list of viral illnesses. Malaria is a parasite. Diphtheria, pertussis and tetanus are bacterial diseases. Herd immunity is irrelevant to them. Speak accurately if you are speaking definitively.
This is on par with RFK Jr talking about the phylum of all viruses.
Perplexity. Totally different experience. Not perfect but very reliable.
08.08.2025 22:50 β π 0 π 0 π¬ 0 π 0Use a better AI tool:
β’ To Kill a Mockingbird by Harper Lee
β’ The Golden Notebook by Doris Lessing
β’ The Bell Jar by Sylvia Plath
β’ The Magic Toyshop by Angela Carter
β’ The Group by Mary McCarthy
β’ We Have Always Lived in the Castle by Shirley Jackson
β’ A Wrinkle in Time by Madeleine LβEngle
Thought the same thing this am when I read the article. The counterpoint concerns the idea that life isnβt just about achievement in your field.
03.08.2025 17:48 β π 1 π 0 π¬ 1 π 0Omg.
01.08.2025 23:51 β π 59 π 11 π¬ 3 π 0This is, in fact, correct using the newest tactic of multi-year funding. NCI paylone dropped from 10% to 4%.
bsky.app/profile/pble...
Thwarted in efforts to reduce the NIH budget, the White House has adopted a new tactic. Force the NIH to pay out a multi-year grant all in the first year, exhausting the NIH budget with ~60% fewer grants. Labs will close everywhere and future year budgets can be spent on junk science.
29.07.2025 10:46 β π 2 π 1 π¬ 0 π 1New, from an anonymous NIH insider: Trump is being pushed to spend more NIH money. The White House is ordering NIH to do multi-year budgets for awards. This budget trick means fewer awards, fewer labs funded, and lower paylines for researchers. π§΅
donmoynihan.substack.com/p/alert-the-...
few outcomes, except for 99% of FDA-approved drugs, 174 recipients of 104 Nobel Prizes, training ~30K MDs and ~10K PhDs per year to enter the workforce, and a 34% reduction in age-adjusted cancer deaths since 1990 -- the largest decrease in history
29.07.2025 03:26 β π 807 π 343 π¬ 14 π 9Did you bother to read the article? Or even the headline?
17.07.2025 14:24 β π 1 π 0 π¬ 0 π 0Did you bother to read the article? Or even the headline?
17.07.2025 14:24 β π 1 π 0 π¬ 2 π 0The absurdity of doing a randomized efficacy trial for the DPT childhood vaccine is so clear. To perform such a trial, you would need to power it to show a reduction in the incidence of a disease. Are we to bring back tetanus (from zero) to test DPT in a placebo-controlled trial? Diphtheria?
15.05.2025 09:44 β π 1 π 0 π¬ 0 π 0Touche
20.03.2025 23:37 β π 0 π 0 π¬ 0 π 0Except in pregnant women and people undergoing urologic procedures.
20.03.2025 21:13 β π 0 π 0 π¬ 1 π 0You took 20 courses in physics and donβt understand why this is a major story? Why the Webb telescope has confirmed the Hubble tension? How this is related to the origin of the universe, particle physics and many of the potentially practical uses of modern physics?
20.03.2025 20:36 β π 0 π 0 π¬ 2 π 0