Mathieu Bourdenx

Differential pathological dynamics triggered by distinct Parkinson patient–derived α-synuclein extracts in nonhuman primates Distinct α-synuclein assemblies trigger distinct neurotoxic cellular pathways.

I’m very happy 🥳 to share our new collaborative work, out today in Science Advances! Many thanks to all the co-authors!

Differential pathological dynamics triggered by distinct Parkinson patient–derived α-synuclein extracts in nonhuman primates | Science Advances www.science.org/doi/10.1126/...

It must be an April fool’s prank

Inside arXiv—the Most Transformative Platform in All of Science Modern science wouldn’t exist without the online research repository known as arXiv. Three decades in, its creator still can’t let it go.

"The biggest mystery is not why arXiv succeeded. Rather, it’s how it wasn’t killed by vested interests intent on protecting traditional academic publishing."

www.wired.com/story/inside...

I like that there is a camera just next to the sign … big brother is watching you!

Inside the Collapse at the NIH Administration officials pressured the NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.

Flabbergasting

www.theatlantic.com/health/archi...

RNA xkcd.com/3056

Sur les retraites, Bayrou a menti.

Le "déficit caché" des retraites n’a jamais existé.

Pour justifier son refus d'abroger la réforme des retraites, il avait inventé un déficit de 55 milliards en 2030.

La Cour des comptes dit que ce sera 5 fois moins. Maintenant : abrogation.

The ground truth for AD is a bit of a debate recently, to say the least! But I am a big fan of the intersection between a clinical diagnosis and a biological definition.

- we need to learn from system biology regarding the interpretation of gene hits. For too long we have relied on imprecise tools (gene ontology) that are often wrongly annotated and cannot sufficiently account for the redundancy of biological systems or the existence of feedback loops

Interesting read! Some thoughts: - a GWAS is only as good as the patient inclusion. There has been immense efforts for AD on that aspect, even doing small postmortem GWAS on path confirmed cases
- the absence of a coherent picture at the gene level might indicate multiple disease mechanisms

🚨Cool Job Alert 🚨consider joining this amazing and rocknroll lab

Tesla paid $0 in federal income tax last year.

2022: $0
2021: $0
2020: $0
2019: $0
2018: $0

Tesla reported $6.7 billion in profit in those years.

Splicing accuracy varies across human introns, tissues, age and disease - Nature Communications Inaccuracies in RNA splicing may play a significant role in aging and disease. Here, the authors present a comprehensive characterization of splicing accuracy across over 14,000 human samples, offerin...

New in @naturecomms.bsky.social: I'm thrilled to share with you our latest work that applies #srRNAseq to understand splicing accuracy across human introns, tissues and in the context of ageing and neurodegeneration www.nature.com/articles/s41...

After spending 4 years in the USA for my postdoc and my daughter being born there, it always felt (and still feels like!) a second home. So it’s utterly sad to see what’s happening now. I stand with all my American friends! Resist ✊💪

Avec son nouveau programme, LFI fait un pas de plus vers la présidentielle EXCLUSIF. Le mouvement de Jean-Luc Mélenchon a mis à jour son programme, l’Avenir en commun, et se prépare plus que jamais à une nouvelle él

Notre programme est prêt.
Nous sommes au travail.

Plutôt que des aventures personnelles, nous faisons des propositions concrètes pour dessiner un horizon souhaitable.

www.leparisien.fr/elections/pr...

That’s completely crazy ! And worrisome …

Still waiting to see most UK and French universities to do the same …

Our brains are very similar at 4am!

Overview of the LEMUR steps: (1) subspace alignment, (2) differential expression, (3) DE neighborhoods, (4) pseudobulking.

After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳

www.nature.com/articles/s41...

LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.

Some highlights⬇️

🔥 chatomics! I regret not learning this well in college—and it changed how I approach bioinformatics today. Here’s my story and why you should avoid my mistake. 🧬

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds - Nature Neuroscience Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least...

Paper alert from the Duff Lab 🚨🚨 My amazing colleagues showed that, in novel MAPTKI models, hyperphosphorylation (in absence of aggregation or even seeding) is sufficient to drive synapse loss and cognitive deficits. Huge implications for preclinical research and the way to therapies. Have a read!!

Congratulations all! Looks great!

Mindblowing paper creating spatial aging clocks 🤯🤯 ! Very neat use of spatial tx. Congrats to @brunetlab.bsky.social and all the authors

Thank you so much 👏🏻🙏😁😁 and well noted about the neurostar forum

Unfortunately so common … but at least you got an answer!!

Global and local ancestry modulate APOE association with Alzheimer’s neuropathology and cognitive outcomes in an admixed sample - Molecular Psychiatry Molecular Psychiatry - Global and local ancestry modulate APOE association with Alzheimer’s neuropathology and cognitive outcomes in an admixed sample

Absolutely! And this should be considered more in genetic studies and preventive medicine, as risk factors can have opposite effects in different ancestries.

www.nature.com/articles/s41...

Help from the MRI community needed: I would like to plot simple regional expression of a protein in the Schaefer atlas. I have a vector of values per region for the atlas. I can’t seem to find my way around that simple thing. Any help will be appreciated!! @nilearn.bsky.social ?

Do you also piece together entire lanes?? 🤣🤣🤣

It seems that a lot of people have transitioned from X to here, however I feel that institutes/centres/unis are still missing.
Did you try to convince yours to move? If so, how?

Phenomenal work! Congrats to all the authors. Is the pipeline already available?