Anesthesia & Analgesia

Financial Implications of Methadone Use in Cardiothoracic Surgery: A Post Hoc Analysis of a Retrospective Cohort

📝 Intraoperative methadone w/ addition of shorter-acting opioids administration was associated with reduced postoperative costs in cardiac surgery.

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🫁Administration of exogenous B cells decreases severity of hyperoxic lung injury, improves oxygenation, & exerts broad immunomodulatory effects in the lungs.

🫁Adoptive B-cell therapy represents an innovative approach to the treatment of ARDS.

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⏱️In uniform pt groups w/ consistent procedures, extubation times follow a log-normal distribution, confirmed by Shapiro-Wilk tests. Awakening is viewed as a uniform distribution of inhalational agent in the brain, leading to a sudden return to consciousness

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Participate in PBLD sessions at the 2026 Annual Meeting hosted by IARS and SOCCA. Engage in intimate, scenario-driven discussions. Reserve your spot now: buff.ly/trw6P5M. Note: Pre-registration and extra fee apply. #IARS2026 #SOCCA2026 @iars360.bsky.social

📚️ The Anesthesiology Milestones evaluations by ACGME aim to track residents' readiness for board-certifying exams.

📚️Final Milestones ratings showed only a modest correlation with the ADVANCED & weak correlations with OSCE.

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🌀Differences in cytokine profiles were observed from day 1 to 1 yr post-surgery between patients w/ & w/o chronic postoperative pain. Those w/chronic pain showed higher levels of Rantes/CCL5 immediately after surgery & increased adipocytokines at 1 year
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🟠 Burnout syndrome affects 21.3% of perioperative healthcare providers in Rwandan public hospitals, with inadequate equipment being a key factor. Three burnout profiles were identified: overextended (38.0%), engaged (37.6%), and ineffective (17.6%).

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Critical care anesthesiology sessions at the 2026 Annual Meeting by IARS and SOCCA will feature emerging research, ICU management strategies, interdisciplinary collaboration and more. Explore sessions: buff.ly/2T3If4g #IARS2026 #SOCCA2026 #CriticalCare #AnesthesiaAndAnalgesia @iars360.bsky.social

🦵Deep neuromuscular blockade did not affect the quality of recovery-40 questionnaire score or the ex vivo cytokine production capacity on whole blood stimulation after total hip arthroplasty

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🫀 TTE revealed a high prevalence of cardiac abnormalities in early onset PreE with severe features, including systolic dysfunction, but unlike in late-onset preeclampsia, Pulmonary interstitial syndrome was not associated with elevated LVEDP.

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👨 🧔‍♀️ Preoperative vaginal estrogen in women and preoperative antiandrogen therapy in men are associated with reduced odds of postoperative AKI after noncardiac surgery.

👨 🧔‍♀️ Preoperative sex hormones might modify the odds of postoperative AKI

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🟥 Pao2 ≥150 mm Hg at 4/24 hours post-ECMO predicted acute brain injury, while Pao2 ≥300 mm Hg at 24 h predicted mortality

🟥 Avoiding hyperoxia during VA-ECMO support may reduce the risk of ABI & in-hospital mortality in pts w/ cardiogenic shock.

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The Role of Damage-Associated Molecular Patterns (DAMP) in Perioperative Neurocognitive Disorders (PND): A Narrative Review

This review offers a focused perspective on DAMP-specific mechanisms and emerging therapeutic interventions that modulate these pathways.

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Involved in #anesthesia research? IARS wants your input! Don't miss your chance to shape global resources! Take this quick survey before March 12: buff.ly/8iUe071 #Anesthesiology #PerioperativeMedicine #MedTwitter #ResearchSupport #IARS

Drs. Patrick Henthron and Thomas Henthorn's editorial "Pharmacogenomic-Based Oral Morphine Dose Adjustment: Is It Hard to Swallow?" is available:

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💊 Pharmacokinetic model-based simulations enhance dosing by accounting for pharmacogenetic variations. To match morphine exposure across genotypes, individuals with 2 loss-of-function alleles may need a 17% IV and 34% oral dose reduction.

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Check out the editorial "Phonomyography: A New Perspective in Perioperative Monitoring of Neuromuscular Blockade?" from Drs. Motamed, Demiri, and Colegrave.

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Join A&A workshops at the 2026 Annual Meeting, presented by IARS and SOCCA, to strengthen your skills in manuscript writing, peer review, and critical appraisal of research. Explore workshops and register:
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#IARS2026 #SOCCA2026 #MedicalResearch @iarsjournals.bsky.social

👉️For non-depolarizing NMBs, the Phonomyography-based neuromuscular monitoring device measured a significantly longer onset, and a shorter recovery time compared with TOF-Watch SX. For depolarizing NMBs, the same trend was also observed.

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Check out the editorial "Signal, Not Noise: Aperiodic Dynamics in the Electroencephalogram Under Anesthesia" from Dr. Christopher Connor.

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🧠Fitting oscillations & one-over-f and variational mode decomposition offer deeper insights into EEG analysis of propofol and fluranes anesthesia and show potential for refinement of future neuroanesthesia monitoring.

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📋️ Less than half of pediatric cardiac anesthesiologists receive formal mentorship or have been sponsored for leadership positions, publications, research opportunities, or speaking engagements.

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⁉️ What is the current state of Peds ❤️‍🩹 Cardiac ❤️‍🩹 #Anesthesiology staffing in the US?

🗝️ Takeaway: We need to recruit, retrain, and provide professional development!
@IARS_Journals @IARS360

Don't miss the editorial about multimodal analgesia in enhanced recovery after cardiac surgery from Drs. Abimbola Faloye & Stephanie Ibekwe:
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✅️ Add anesthesia-related variables to clinical databases
✅️ Develop prospective studies w/ patient-centered outcomes.

💙 In a cohort of elective cardiac surgical patients, use of multimodal analgesia was not associated with a lower maximum postoperative pain score 3 days after cardiac surgery but was associated with fewer initial mechanical ventilation hours after surgery.

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Checkout our February 2026 Video Summary outlining our featured articles in this month's issue:

💉 Spectral Differences of Anesthetic Agents
❤️ERAS in Cardiac Surgical Patients:
👶 Pediatric Cardiac US Anesthesiology Staffing

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Errors are inevitable.

How do we reinforce #professionalism while preserving #humility in #medicine?

This A&A Practice piece reflects on taking "an ethical pause". Beautiful read.

#MedHum #Humanism #Anesthesia

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Perioperative Health Care Disparities in the US: A Systematic Review

Disparities were found in peripartum management, mortality, complications, regional anesthesia use, and pain management, in Black & Hispanic women, older adolescents, & uninsured/Medicaid

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💉Different positional relationships between the probe, needle, and puncture model can affect the speed and success rate of in-plane puncture and the ultrasound-guided in-plane puncture difficulty followed the order VP > HP = VV > HV.

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Automated Robotic Airway Insertion Using Flexible Optical Bronchoscope in a Manikin: A Feasibility Pilot Study

🤖 First-attempt success rates & performance scores w/ robot-assisted modes were similar to manual insertion by experienced anesthesiologists

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