Christophe Biot

From Molecule to Meaning: Click and Bioorthogonal Chemical Reporters for Plant Systems, Biological Imaging, and Artistic Expression At the intersection of chemical biology, plant imaging, and contemporary art, this review introduces the concept of chembioart. By tracing how chemical reporters illuminate plant biomolecules in vivo...

From Molecule to Meaning: Click and Bioorthogonal Chemical Reporters for Plant Systems, Biological Imaging, and Artistic Expression - Hinnebo - ChemBioChem - Wiley Online Library chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Check out the Readers' Choice collection over at #ChemBioChem and browse their top articles from recent years: chemistry-europe.onlinelibrary.wiley.com/doi/toc/10.1...

#ChemBio #ChemSky #Chemistry

Optical Control of Membrane Viscosity Modulates ER-to-Golgi Trafficking The lipid composition of cellular membranes is highly dynamic and undergoes continuous remodeling, affecting the biophysical properties critical to biological function. Here, we introduce an optical a...

Excited to share our new @pubs.acs.org paper! We engineered cells with ~10% photolipids in the ER membrane. This enabled optical control of membrane viscosity to study its impact on ER→Golgi protein transport. @dirktrauner.bsky.social @noemijimenezrojo.bsky.social

pubs.acs.org/doi/10.1021/...

Alejandro Martin-Hoyas receiving his poster prize

Athi Welsh receiving his poster prize

And congratulations to Athi Welsh (University of York) and Alejandro Martin-Hoyas @imdeananociencia.bsky.social , winners of the Poster Prize sponsored by Metallomics!

Sreejani Ghosh receiving a poster prize

🎉 Bravo also to Astrid Dagmar Bernkop-Schnürch (Medical University of Innsbruck) and hats off to Sreejani Ghosh (VIT, India), who both were awarded a @chemistryeurope.bsky.social Poster Prize!

And here are the five winners of the Poster Prizes, congrats to all starting with Alfonso Annunziata @imdeananociencia.bsky.social, Poster Prize Winner at #ISBOMC25, sponsored by @chemistryeurope.bsky.social Europe, for his outstanding research and presentation.

🌸 Every 2 years, the orchid event not to be missed is back in Wallers! Sept 26-28, 2025: growers from all over the world, orchid show & sale, talks and workshops 🌍 Collectors, beginners or families – join us for the great orchid celebration! 🌱
#orchidshow #orchidaddict #orchidlover #orchids #Wallers

🌸 Tous les 2 ans, l’événement orchidophile à ne pas manquer revient à Wallers ! Les 26-28 sept. 2025, producteurs du monde entier, expo-vente, ateliers et conférences 🌍
Passionnés, curieux ou familles : rejoignez la fête des orchidées ! 🌱✨

#orchidées #Wallers #exposition #nature #plantes #fleurs

Photoactivatable Cyclometalated Ir(III) Compound Penetrates the Blood-Brain Barrier in 3D Spheroidal and Advanced 3D Organoid Models of Inherently Resistant and Aggressive Brain Tumors The blood-brain barrier represents a significant challenge in delivering anticancer drugs for glioblastoma treatment. The study investigates the potential of a series of octahedral photoactivatable cyclometalated iridium complexes (Ir1–Ir10) with the general formula [Ir(ttpy)(C∧N)Cl]PF6 as photoactivated therapy candidates for the treatment of this aggressive tumor. These complexes, which include the terdentate ligand 4′-(p-tolyl)-2,2′:6′,2″-terpyridine (ttpy), and a C∧N ligand based on the deprotonated 2-arylbenzimidazole backbone, were tested on human glioblastoma using 2D cell cultures and 3D spheroidal models, including a fusion system comprising cerebral organoids from nonmalignant human-induced pluripotent stem cells and spheroids derived from malignant brain cells. The iridium complexes catalyze NADH photooxidation and photogenerate 1O2 and/or •OH under blue light irradiation. Blood-brain barrier penetration was assessed using various in vitro models. The complex Ir4, containing deprotonated methyl 1-butyl-2-phenylbenzimidazolecarboxylate, shows promise for targeted therapy of resistant brain tumors when photoactivated with blue light. Ir4 induces rapid and sustained ROS-mediated cytotoxicity and selectively accumulates in tumor tissue. This suggests its potential for fluorescently guided-PDT cooperative resection of glioblastoma. Notably, Ir4 significantly reduces glioblastoma growth even under dark conditions compared to conventional Temozolomide treatment without affecting healthy brain tissue.

Glad to share our last studies in collaboration with Viktor Brabec.
Photoactivatable Ir(III) Compound Penetrates the Blood-Brain Barrier in 3D Spheroidal and Advanced 3D Organoid Models of Inherently Resistant and Aggressive Brain Tumors | ACS Pharmacol & Transl Science pubs.acs.org/doi/full/10....

Happy to see the new paper from our great collaboration with @kargesgroup.bsky.social on #PDT, #Iridium and #HSA conjugation! Thanks to all-coauthors & also to @ruhr-uni-bochum.de, @UMU & @AEI

Honored to give an invited talk at @isbomc25.bsky.social in Paris on iridium-based photodynamic therapy for cancer. Huge thanks to the organizers for the opportunity! @gassergroup.bsky.social

How International is the International Symposium on BioOrganometallic Chemistry ?
30 countries from all continents are represented!
The first four talks of this morning session already made us jump from Houston, to Paris, to Cape Town, to Macau!

Group picture at ISBOMC25

Group picture at ISBOMC25 in Chimie ParisTech Library

What a beautiful sunny day in Paris, perfect for a group picture! (@chimieparistechpsl.bsky.social Library is also a nice setting for an inside group picture).

The many modes of action of Gold Complexes against cancer

Prof. Maria Contel @contellab.bsky.social starts the 3rd day, discussing gold complexes for anticancer applications and showcasing the many modes of action they can exert.

The first pictures of the conference are online, food science and smiles!

isbomc25.sciencesconf.org/resource/pag...

Recent progress of glycomimetics in drug development Naturally occurring carbohydrates and glycomimetics have been extensively studied in the treatment of various diseases in which carbohydrates are the lead compound, as glycomimetics can simulate the…

Take a look at this Review article by Xiaolei Wang & co discussing the recent progress of glycomimetics in drug development⬇️

pubs.rsc.org/en/content/a...

📍Lanzhou University and Wuhan Textile University 🧪

Voyage auditif au cœur de la terre : redécouvrir Derinkuyu par l’acoustique 3D Voyage auditif au cœur de la terre : redécouvrir Derinkuyu par l’acoustique 3D

www.archeologie-actualites-et-decouvertes.fr/2025/05/voya...

Voyage auditif au cœur de la terre : redécouvrir Derinkuyu par l’acoustique 3D

#archéologie #histoire #voyage

"Les marchés nous amènent des tarifs négociés !"

123€ pour une chambre sans petit déjeuner dans un motel au bord d'une route sans trottoir.

Si je réserve moi-même pour lundi prochain c'est 84€

The annual @icbschembio.bsky.social conference, alternating between Northern America and other continents since 2011, returns to Europe in Paris, Oct. 6-9, 2025. This joint edition with the European Chemical Biology Symposium marks its first European appearance since Berlin 2015.

A ne pas rater demain 28 avril - 14h
Andrea Rentmeister, recipient of the 2024 Franco-German “Georg Wittig - Victor Grignard” Prize, awarded by the Société Chimique de France, with the support of @scf-chembio.bsky.social, on the @univparissaclay.bsky.social campus, at @institutcurie.bsky.social.

Ne ratez pas cette conférence exceptionnelle - Institut Curie - Orsay - Amphithéâtre Nelly Riguet - Bat 111 - 14h - 28/04/2025

Whaou!! So cool!! Congrats Anne!! 🎉🎊

Hi @carolynbertozzi.bskyverified.social . A 500 pieces puzzle that was made for Glycobiology GRC students using a #glycotime illustration from you ! Now ready for you to try it (tell me if someone from your lab is at glyco27 or SFG 2025 for delivery)

Not just obesity: GLP-1 receptor agonists advance on addiction - Nature Biotechnology GLP-1 agonists may lessen alcohol, smoking and possibly drug addictions. Evidence from clinical trials remains sparse, but that is about to change.

Will the 'skinny jabs' become known as the 'buzz killers'? GLP-1 receptor agonists have curbed some people's #addictions to #alcohol, #smoking, #cocaine, or #opioids. Research is gaining real momentum. Just out in Nature Biotechnology @natbiotech.nature.com www.nature.com/articles/s41...

The Cure: Neue Musik an Robert Smiths Geburtstag Am Dienstag wird Robert Smith 66 Jahre alt. Dann soll von The Cure auch „MOALW“ erscheinen: „Mixes of a Lost World“

" #TheCure: New music on Robert Smith's birthday.

On Tuesday, #RobertSmith will be 66 years old. Then The Cure will also release "MOALW": "Mixes of a Lost World".

Meet Arthur, the first deep-sea robot archaeologist

#CNRSnews 📰 Designed for underwater archaeology, the new remotely-operated vehicle Arthur explores the seabed at unprecedented depths of up to 2500m and recovers objects without damaging them, while providing invaluable information on deep-sea ecosystems 🐚

"Big surprise": astronomers find planet in perpendicular orbit around pair of stars Astronomers have found a planet that orbits at an angle of 90 degrees around a rare pair of peculiar stars. This is the first time we have strong evidence for one of these ‘polar planets’ orbiting a s...

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Source : www.eso.org/public/news/...

Image d'artiste d'artiste de l'orbite inhabituelle de l'exoplanète 2M1510 (AB) b autour de ses étoiles hôtes, deux naines brunes. La planète récemment découverte possède une orbite polaire, perpendiculaire au plan dans lequel évoluent les deux étoiles.

Image, prise en lumière visible, du Système 2M1510. On voit 2 points rougeâtres : l'étoile 2M1510 C, et juste au-dessus un autre point, le système binaire qui nous intéresse : 2M1510 AB, une paire de naines brunes en orbite l'une autour de l'autre. Ces deux naines brunes, A et B, apparaissent comme une seule source sur cette image, mais elles sont bien deux car elles s'éclipsent mutuellement, périodiquement.

Surprenante découverte d'une exoplanète orbitant à un angle de 90 degrés autour d'une paire de naines brunes (des étoiles "ratées" trop petites pour s'allumer).

C'est la 1ère fois qu'on dispose de preuves solides de l'existence d'une « planète polaire » en orbite autour d'une paire d'astres.

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1905, après la découverte de Planck en 1900.
On en parle dans le dernier exposé mis au point par l'unité de Physique du Palais de la découverte : "introduction à la mécanique quantique".
Prochaines séances : jeudi 24 avril à 14h20 et dimanche 17 mai à 13h.
C'est aux Étincelles du Palais #Paris15