UGSF-Glycobiology

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID-related Rounds), which have witnessed the transition to AI-driven predict...

🧬 New paper out from our Computational Molecular Systems Biology team at @UGSF-lille !
Proud to have contributed to the CAPRI 8 challenge

🔗 Read it here: onlinelibrary.wiley.com/doi/10.1002/...

#CAPRI8 #AlphaFold #ProteinStructure #StructuralBiology #AIinBiology #Bioinformatics #UGSF

🔬 Les équipes lilloises d’Isabelle Landrieu et Luc Buée ont montré l’intérêt de nanobodies™ qui lient la protéine tau et empêchent sa pénétration dans les cellules cérébrales, bloquant ainsi sa propagation.
🚀Une avancée pour des thérapies ciblées contre Alzheimer 👉 pasteur-lille.fr/2025/04/30/p...

Novel Click Coupling Chemistry to Explore Glycan Recognition Specific recognition of glycans by proteins is important in many biological processes and immune responses. Here we present a general approach for derivatizing free glycans with a novel linker MTZ (3-...

📢 Our latest work describing a new versatile click chemistry glycan linker which enabled us to create glycan derivatives for use in microarrays, Luminex (bead based arrays) and ELISA assays.

Check it out in @acs.org ACS Central Science doi.org/10.1021/acsc...

#glycotime #clickchemistry #luminex

YouTube video by Ylizur - Journaliste Scientifique Ô Labo ! 🧪Au cœur du vivant avec l'équipe de l'UGSF !

Vous avez toujours rêvé de visiter un laboratoire de biologie ? 🧐

Découvrez l' @ugsf-lille.bsky.social en compagnie de @ylizur.bsky.social, Corentin Spriet et les équipes de l'unité dans ce replay du live du 20 mars !
youtu.be/SqTEuVX8HF0

@cnrsbiologie.bsky.social @univlille.bsky.social

👋 @lkremer1.bsky.social @cnrs-hautsdefrance.bsky.social @inserm.fr @univlille.bsky.social @ugsf-lille.bsky.social @umontpellier.bsky.social

👉 Lire l'article dans @naturecomms.bsky.social

buff.ly/Z5szsdt

Thank you to the Mizutani Foundation for Glycoscience for partnering with #Glyco27, taking place May 25-30, 2025 in Edmonton!

Join us to explore the latest in #glycoscience and #biotechnology: www.glyco27.org/en/begin

Want to partner? glyco27.org/en/sponsor

@glycotime.bsky.social

yes, please read the reply to the first message 😀

A glycosylated lipooctapeptide promotes uptake and growth of Mycobacterium abscessus in the host Nature Communications - Leclercq et al report the structure of a glycosylated lipooctapeptide (GL8P) produced by Mycobacterium abscessus. GL8P is shown to induce a strong humoral response in...

Here is the link to the open access manuscript : www.nature.com/articles/s41...

New study in Nature Communications: We identified a novel surface glycoconjugate essential for Mycobacterium abscessus virulence—a potential diagnostic target. Huge thanks to the amazing collab btw @lkremer1.bsky.social, JL Herrmann & @yguerardel.bsky.social
@cnrsbiologie.bsky.social

🚴‍♂️ Lille, Glycoscience capital of France ! 🚴‍♂️

95km cycling around Lille by our colleague @yguerardel.bsky.social today, following glucose's path. Rough pavements between C1 and C2 & headwinds between C5 and hemiacetal oxygen.

Next goals: add the C6 and train hard for sialic acid (9 carbons😓)!

🚀 Ready to boost your glycobiology skills?

Join our INSERM-backed workshops, “Glycobiology: the sweet side of life in heath and disease”, led by top experts!

📍Theory: Bordeaux - Oct 15–17, 2025)

📍Practice: Lille/Nancy Nov 12–14, 2025

Register now until June 27 : tinyurl.com/2mzf5dy3

The Late-Stage Steps of Burkholderia cenocepacia Protein O-Linked Glycan Biosynthesis Are Conditionally Essential. Periplasmic O-linked protein glycosylation is a highly conserved process observed across the Burkholderia genus. Within Burkholderia , protein glycosylation requires the five gene cluster known as the...

for my first bluesky post I'm happy to share a fun project from the lab we have been working on for a few years exploring the essentiality of genes involved in o-linked protein glycan biosynthesis in Burkholderia! www.biorxiv.org/content/10.1...

🌾 Our new research shows that vibrational spectroscopy (FT-IR) effectively monitors flax dew retting, crucial for high-quality fibers. Using multivariate analysis, we identified key spectral changes, revealing more candidates than traditional methods. tinyurl.com/3sjdnb29

@cnrsbiologie.bsky.social

If, like us, you love getting lost in the Tree of Life, check out the updated version of 🌳🔍 lifemap.cnrs.fr — developed by @damdevienne.bsky.social at @cnrsbiologie.bsky.social. It's more amazing than ever! 🌟 #TreeOfLife #Science #Biodiversity

If, like us, you love getting lost in the Tree of Life, check out the updated version of 🌳🔍 lifemap.cnrs.fr — developed by @damdevienne.bsky.social at @cnrsbiologie.bsky.social. It's more amazing than ever! 🌟 #TreeOfLife #Science #Biodiversity

When beauty overshadows scientific genius

#CNRSnews 📰 As the world celebrates International Women’s Day, CNRS News looks at the scientific achievements of Hollywood actress Hedy Lamarr and the little consideration her findings were given, like those of other female scientists throughout history

Merci @juliencherfils.bsky.social pour cette excellente collaboration avec les équipes de notre laboratoire, et félicitations pour ces superbes résultats. Glycolipids rock!

The ‘very moment’ when UDG recognizes a flipped-out uracil base in dsDNA - Scientific Reports Scientific Reports - The ‘very moment’ when UDG recognizes a flipped-out uracil base in dsDNA

New paper out! 🚀 Our latest publication from the ANR project DYPROSOME is now published in *Scientific Reports*. Check it out: www.nature.com/articles/s41...
Project link: anr.fr/Project-ANR-...

How are calcium and glycosylation linked? Dr. Foulquier’s team reveals SLC10A7’s role in balancing calcium in the ER & Golgi, essential for proper glycosylation. SLC10A7 regulates COSMC/C1GALT1, impacting mucin-type glycosylation. More coming soon!
Full story here link.springer.com/article/10.1...

How are calcium and glycosylation linked? Dr. Foulquier’s team reveals SLC10A7’s role in balancing calcium in the ER & Golgi, essential for proper glycosylation. SLC10A7 regulates COSMC/C1GALT1, impacting mucin-type glycosylation. More coming soon!
Full story here link.springer.com/article/10.1...

UGSF is excited to announce our paper in RSC Chemical Biology on developing multimodal molecular probes for glycosylation bioimaging. This work, with LASIRe (Lille) & ESRF (Grenoble), is featured on the March 2025 cover! Read more: doi.org/10.1039/D4CB...

Research taps into sugary secrets of plant nectar to bite back against mosquito-spread disease In a study published in Scientific Reports, researchers from the Royal Botanic Gardens, Kew, working with partners in Africa and the UK, present a novel plant-host identification method that could hel...

SUGARS, again
phys.org/news/2025-02...

Poste d’ingénieur(e) de recherche CNRS – 18 mois – Marseille
Rejoignez notre équipe sur un projet de prématuration du CNRS ! Nous recherchons un(e) ingénieur(e) de recherche spécialisé(e) en microbiologie, biologie moléculaire et en microscopie.
🫵 🔬👨‍🔬👩‍🔬

emploi.cnrs.fr/Offres/CDD/U...

🐠✨ Comment le poisson-clown échappe-t-il aux toxines de son anémone protectrice ? Grâce à… son mucus ! 🧐

Un nouvel épisode passionnant du podcast Avec Sciences sur @franceculture.fr explore cette incroyable adaptation. 🌊🔬

🎧 À écouter ici 👉 buff.ly/3XoPQwj

New MassiveFold release 1.4.0: it is now possible to model ligands and glycosylations with AlphaFold3!

MassiveFold is a software for molecular structure prediction with AlphaFold2, ColabFold and AlphaFold3.

More details : github.com/GBLille/Mass...

Publication : www.nature.com/articles/s43...

#ResultatScientifique 🔎| Découvrez la dernière publication de Sébastien Léon et de ses collaborateurs ⤵️

🤝 @cnrs-idf-villejuif.bsky.social @upcite.bsky.social @ijmonod.bsky.social
📕 Biology of the Cell | https://buff.ly/41pMQ5m

A POGase is a huge advance in the glycomics field, which has typically relied on chemical or incomplete enzymatic releases (no Sia).
Expect a lot of multi-omic studies enabled by this (N-glycomics, O-glycomics, and proteomics) since the peptide backbone is left intact.
www.nature.com/articles/s41...

Happy to share a new publication from our UGSF collaborator David Dauvillée @chlamyd0.bsky.social

Please follow the work of Shubham Semwal ESR at UGSF and his co-supervisors. Thank you @glycojones.bsky.social for the interview!

A new UGSF study, in collaboration with our Japanese partners, unravels a century-old mystery about clownfish symbiosis—and yes, sialic acid plays a role! 🐠🔬 #Glycoscience #Clownfish #Research