Zierhut Lab

Senior Research Technician at University of Birmingham Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...

PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) in Chelsea | The Institute of Cancer Research View details and apply for this PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) vacancy in Chelsea . Salary: Dependent on relevant Postdoctoral exp...

We're hiring ! Specifically....we are seeking to appoint a creative and motivated Postdoctoral Training Fellow to study how drug resistance emerges in homologous recombination defective (HRD) breast cancers and how this could be targeted. jobs.icr.ac.uk/vacancies/13...

#Jobalert 🚨: looking for a #computationalbiology expert with track record in analysis, integration and interpretation of #omics datasets, in particular #epigenomics, #singlecellgenomics, #proteomics data. uni-freiburg.de/stellenangeb... short deadline 30th September!

🎉🎉🎉

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...

US drugmaker Merck scraps £1bn London research centre and cuts 125 science jobs New blow to UK’s key life science sector as industry body says country is losing ground on investment and research

Academic research generates almost all intellecutal innovation in the life sciences. With big pharma refusing to contribute, maybe it's time to stop giving them our research outputs cheaply, and instead having globally nationalised means of translating innovation?
www.theguardian.com/business/202...

Congratulations!!

Congratulations, Uli! Really interesting!

Great story from our fantastic neighbour Jörg Mansfeld!

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase controls its stability. Loss of C41 oxidation increases p21 stability, impairs proliferation, and promotes senescence after irradiation.

Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:

Excellent! See you there!

Yes absolutely! You going to the Mechanobiology of the Nucleus meeting?

Congratulations, Abby!

Congrats Adrian! Cool to see this story develop with new and exciting results!

Fantastic joint lab meeting day with @eileenparkes.bsky.social and Ben O'Leary plus our groups. Lots of cool science and discussions! And that fancy dinner at Lincoln College!

It was such a great and inspirational day! Thank you very much for having us!

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Fantastic news! Great to see this out now! Congratulations!

Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis - Nature Communications The authors establish the ChIP-CryoEM method, which combines chromatin immunopurification coupled with cryo-electron microscopy, to visualize native human RNAPII elongation complexes in action, with a...

Nice work by the Kurumizaka Lab in @natcomms.nature.com

Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis

www.nature.com/articles/s41...

Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social.
www.sciencedirect.com/special-issu...

Congrats! Looking forward to reading this!

Cool! Looking forward to reading this!

Thank *you*, Bungo! It was such a stimulating seminar, and great discussions!

Congratulations!

Really looking forward to your visit as well!

Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info

Such a cool story!

PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...

If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...

Great work! Congratulations!