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Zierhut Lab

@zierlab.bsky.social

Genome Stability and Innate Immunity Lab at the Institute of Cancer Research, London https://www.zierhutlab.org/

849 Followers  |  604 Following  |  30 Posts  |  Joined: 27.09.2023  |  1.6796

Latest posts by zierlab.bsky.social on Bluesky

Congrats Adrian! Cool to see this story develop with new and exciting results!

03.07.2025 07:59 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Fantastic joint lab meeting day with @eileenparkes.bsky.social and Ben O'Leary plus our groups. Lots of cool science and discussions! And that fancy dinner at Lincoln College!

27.06.2025 14:49 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

It was such a great and inspirational day! Thank you very much for having us!

27.06.2025 14:04 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

20.06.2025 09:38 β€” πŸ‘ 77    πŸ” 80    πŸ’¬ 1    πŸ“Œ 2

Fantastic news! Great to see this out now! Congratulations!

03.06.2025 08:05 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

29.05.2025 11:26 β€” πŸ‘ 23    πŸ” 35    πŸ’¬ 0    πŸ“Œ 0
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Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis - Nature Communications The authors establish the ChIP-CryoEM method, which combines chromatin immunopurification coupled with cryo-electron microscopy, to visualize native human RNAPII elongation complexes in action, with a...

Nice work by the Kurumizaka Lab in @natcomms.nature.com

Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis

www.nature.com/articles/s41...

29.05.2025 07:12 β€” πŸ‘ 34    πŸ” 8    πŸ’¬ 2    πŸ“Œ 0
DNA Repair | The replication stress response: mechanisms and functions | ScienceDirect.com by ElsevierScienceDirect High-fidelity DNA replication is constantly challenged by a diverse range of obstacles, including endogenous lesions and secondary structures in the DNA template, tightly bound protein-DNA complexes, ...

Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social.
www.sciencedirect.com/special-issu...

17.04.2025 04:01 β€” πŸ‘ 39    πŸ” 14    πŸ’¬ 1    πŸ“Œ 1

Congrats! Looking forward to reading this!

10.04.2025 08:46 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Cool! Looking forward to reading this!

10.04.2025 08:00 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Thank *you*, Bungo! It was such a stimulating seminar, and great discussions!

20.03.2025 18:21 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Congratulations!

19.03.2025 09:24 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Really looking forward to your visit as well!

19.03.2025 09:23 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1

Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info

12.03.2025 14:51 β€” πŸ‘ 7    πŸ” 15    πŸ’¬ 1    πŸ“Œ 0

Such a cool story!

07.03.2025 17:42 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...

If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites πŸ™„) www.nature.com/articles/s41...

05.03.2025 14:44 β€” πŸ‘ 34    πŸ” 11    πŸ’¬ 2    πŸ“Œ 0

Great work! Congratulations!

05.03.2025 15:01 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Yardimci Lab | Single-molecule visualisation of the eukaryotic replication machinery

A new PhD position is available in my lab to explore DNA replication mechanisms using single-molecule approaches. Apply by 19th of March:

www.crick.ac.uk/careers-stud...

04.03.2025 11:39 β€” πŸ‘ 9    πŸ” 14    πŸ’¬ 0    πŸ“Œ 0

Congratulations!!

01.03.2025 09:19 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

I exported every collection as a .ris file. This way, the imported records came along with their pdfs. But I had most pdfs locally on my computer so I don't know if the pdfs would be imported if you don't have them locally.

26.02.2025 14:58 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

In the end what worked best was to export/import the collections one by one. It's a bit painful (I have so many of them!) but it's already worth it. Zotero is so much better. Thanks for the suggestion!

26.02.2025 07:42 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

What a terrible loss!

25.02.2025 13:33 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Adrian, I'm just playing round with this at the moment, and haven't found a way to export from Papers that keeps collections intact upon import into Zoteo. Is there a way? (I've tried .bib .ris and .csv so far. Haven't yet tried to go via Mendeley intermediate).

24.02.2025 16:52 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Highly recommended!

21.02.2025 14:21 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Still a few days left to apply! I'm recruiting for two Postdoc positions in my lab at the University of Birmingham, investigating the Alternative Lengthening of Telomeres.

21.02.2025 07:49 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Postdoctoral Training Fellow – X-Ray Crystallography in Sutton | The Institute of Cancer Research View details and apply for this Postdoctoral Training Fellow – X-Ray Crystallography vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Future progression is base...

Are you interested to work in cancer drug discovery? Come and join us, we are recruiting a protein crystallographer to strengthen our structure-based drug discovery efforts.
jobs.icr.ac.uk/vacancies/11...

21.02.2025 09:12 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Higher Scientific Officer - Protein production, purification and assay specialist in Sutton | The Institute of Cancer Research View details and apply for this Higher Scientific Officer - Protein production, purification and assay specialist vacancy in Sutton. Salary : Commencement on the salary range is subject ...

We are recruiting a Higher Scientific Officer experienced in recombinant protein production and assay development to join an exciting collaboration to develop novel small molecule-controlled molecular switches to modulate CAR-T cell activity.
jobs.icr.ac.uk/vacancies/11...

21.02.2025 09:22 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Interested in exploring epigenetic cell memory? Join us!! 6 PhD and postdoc positions available in our new center, EpiC.

12.02.2025 23:11 β€” πŸ‘ 18    πŸ” 12    πŸ’¬ 0    πŸ“Œ 1

Dear all,

Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk

10.02.2025 14:45 β€” πŸ‘ 37    πŸ” 36    πŸ’¬ 1    πŸ“Œ 0
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Postdoctoral Training Fellow in Chelsea | The Institute of Cancer Research View details and apply for this Postdoctoral Training Fellow vacancy in Chelsea . Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performan...

At #EMBOinsitu and looking for a motivated postdoc joining an interdisciplinary project in my lab:
jobs.icr.ac.uk/vacancies/11...
the-alfieri-lab.co.uk
#cryoem #cryotem

05.02.2025 22:05 β€” πŸ‘ 9    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

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