Christian Zierhut

Christian Zierhut

@zierlab.bsky.social

Genome Stability and Innate Immunity Lab at the Institute of Cancer Research, London https://www.zierhutlab.org/

928 Followers 693 Following 69 Posts Joined Sep 2023
2 weeks ago
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👋 To all aneuploidy and chromosome instability aficionados check out the Consequences of Aneuploidy FASEB conference (Florida-USA 🏖️) co-organised with @peterlylab.bsky.social, Mike Lampson, Alison Taylor and myself: events.faseb.org/event/Aneupl...
👉 Deadline for abstract submission: August 3rd.

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2 weeks ago
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You are interested in immunology and how nucleic acid structures contribute to their function and how this impacts disease development - Rayk Behrendt and myself have open PhD positions for a joint PhD program between Bonn and Osaka.

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3 weeks ago
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To kickstart this new Bluesky account: We're hiring!
The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab.
Details in the flyer — get in touch! 👇

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1 month ago

NOW LIVE!: PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...

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1 month ago

Congratulations!!

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1 month ago
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Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity Ostendorf et al. show that activation of liver-X-receptors preconditions T cells to render them more receptive to adopting effector states upon activation.

Delighted to share our new paper on LXR agonism pre-conditioning T cells to more readily adopt effector states, out in @jem.org today. This was a long project started in @sohailtavazoie.bsky.social's lab and completed across the atlantic here in Berlin at Charité.

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1 month ago
Early Career Researchers Response to UKRI Investment Approach

If you're a physics researcher, please sign this letter. Anyone in the biomedical sciences know of a similar letter for our fields? Or anyone interested in putting one together? ecr-openletter-stfc.github.io#sign-form

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1 month ago
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UK ‘could lose generation of scientists’ with cuts to projects and research facilities UK’s research funding body says best scientists are taking posts overseas due to lack of job stability at home

Physics are hit worst, but it's not just physics. @ukri.org, it's not too late to reverse course. www.theguardian.com/science/2026...

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1 month ago
Postdoctoral Fellow - Cellular signalling and cytoskeletal function lab

2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...

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1 month ago

In any case, regardless of any potential future emphasis on commercial enterprises, nothing that was said by Ian Chapman justifies the pause in research funding. Surely re-orienting can be achieved without this pause?

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1 month ago

In contrast, in discovery science, research is published, and thereby available to benefit everyone, not just a few investors or company founders.

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1 month ago
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UK’s £8bn research fund faces “hard decisions” as it pauses new grants UKRI boss Ian Chapman said it had been told by the government to

As I predicted, the cutting of @ukri.org funding is to provide "more emphasis on commercialisation". This is an absolutely terrible decision. Most startups fail, or are bought by larger competitors. In both cases, their research is frequently lost from the public domain www.bbc.co.uk/news/article...

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1 month ago

Awesome! Congratulations!

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1 month ago

Congratulations!!

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1 month ago

Exactly. Apart from the madness of halting funding for a period of time, this seems to herald a shift from long-term research investment to supporting short-term business interests.

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1 month ago

It would be very helpful if this letter could be distributed to other news outlets as well, as it should be widely available and not paywalled.

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1 month ago

Yes @ukri.org, please provide clarity and reasons for this chain of events. It would be a huge disadvantage to UK innovation if we went down a path of science funding that is similar to Trump's USA.

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1 month ago

I wasn't even aware of that. Unbelievable.

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1 month ago

It's also absolutely devastating to observe the UK being taken down a Trumpian path in yet one more context. We all were abhorred by news of slashed NIH study sections. And now the same is being done to us...by a "Labour" government.

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1 month ago

This is an absolute outrage that should be discussed as widely as possible. I expect that this failing government will try and use the MRC to divert funding from academic research into commercial enterprises, killing UK research in the process.

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1 month ago

I don't understand why the current grant rounds cannot continue as planned whilst the UKRI is repositioning itself. I also do not understand how this is not discussed in any news outlets. It will massively set back UK-based biomedical research.

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2 months ago

Great news to see this out now! Congratulations!

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2 months ago

I would also like to say that this was the first time I wrote a review across research groups, combining complementary expertise. It was a lot of fun, and I also learned a lot in the process.

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2 months ago
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Mitotic errors as triggers of cell death and inflammation - Nature Cell Biology Rizzotto et al. discuss the causes and consequences of deregulated mitosis that allow cells arrested in mitosis to escape to the next interphase, where they can initiate inflammatory signalling or und...

Excited to announce a new review article that Andreas Villunger @villungerlab.bsky.social, Dario Rizzotto (not on bsky) and I wrote. In this article, we discuss mitosis as a central cell cycle stage for integrating DNA damage, cell death and inflammatory responses. www.nature.com/articles/s41...

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2 months ago
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Parkes lab pre-print alert! ‘TMEM33 deletion potentiates anti-tumor CD8⁺ T cell immunity.’ Led by mtjackson101.bsky.social. Full bluetutorial follows! 1/10 www.biorxiv.org/content/10.6...

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2 months ago
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Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...

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2 months ago
Deciphering genetic susceptibility to clear cell renal cell carcinoma - Communications Biology Integration of genome-wide association data with epigenomic and chromatin interaction data identifies target genes mediating clear cell renal cell carcinoma risk, implicating disrupted hypoxia signall...

We are pleased to present our manuscript on the annotation of clear cell Renal Cell Carcinoma #GWAS risk loci, recently published in @commsbio.nature.com

www.nature.com/articles/s42...

#ccRCC #cancer #genetics #genomics #KidneyCancer

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2 months ago

Fantastic! Congratulations!!

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3 months ago

And most of these appearances without even having won the mandate for a single constituency seat!

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3 months ago

Awesome!! Congratulations!!

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