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Jake Choby

@jakechoby.bsky.social

Assistant Professor, University of North Carolina Antibiotic heteroresistance in Enterobacterales chobylab.org

389 Followers  |  142 Following  |  6 Posts  |  Joined: 11.11.2024  |  1.6765

Latest posts by jakechoby.bsky.social on Bluesky

Super excited to share our paper online 🚨today🚨 in Cell Host & Microbe‬! Xiaomei Ren @xiaomeiren.bsky.social and Mason Clark @rmasonclark.bsky.social‬ co-led discovery of ecological factors for Acinetobacter baumannii carriage in the gut, a reservoir for pathogen spread. πŸŽ‰

tinyurl.com/443kfefk

04.08.2025 20:26 β€” πŸ‘ 84    πŸ” 40    πŸ’¬ 11    πŸ“Œ 2

Thanks to my colleagues, friends, and especially mentors @dweisslab.bsky.social and Eric Skaar for guidance along the way

02.07.2025 14:48 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

It's a good time to mention that I’ve just started as an assistant professor at the University of North Carolina SOM, Micro & Immuno, where we will work to understand mechanisms that generate heteroresistance and phenotypic heterogeneity in Enterobacter and other multi-drug resistant Gram- pathogens

02.07.2025 14:43 β€” πŸ‘ 15    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting Ξ²-lactamase genes in heteroresistance enables resistance of continua of cellular...

Excited to share the work with @dweisslab.bsky.social‬ and great collaborators on how gene amplification generates dynamic heteroresistance to new beta-lactams, like cefiderocol. We hope drug developers will consider heteroresistance during antibiotic development rdcu.be/euijW

02.07.2025 14:43 β€” πŸ‘ 24    πŸ” 12    πŸ’¬ 2    πŸ“Œ 3
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So much joy to see everyone today coming together to celebrate 20 years of the Skaar Lab. Thank you to Eric for the leadership and mentorship over the years! πŸ₯°

05.04.2025 23:00 β€” πŸ‘ 53    πŸ” 11    πŸ’¬ 1    πŸ“Œ 0

Congrats! Such a cool story

21.03.2025 15:48 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Zinc-dependent Ξ²-lactam resistance at a cost - Nature Microbiology Chemical genomics reveals the fitness cost of bacterial metallo-Ξ²-lactamase in zinc-deplete environments, with implications for treatment options.

News & Views πŸ“„ - Zinc-dependent Ξ²-lactam resistance at a cost

By Jacob Choby & David Weiss

www.nature.com/articles/s41...

06.01.2025 22:50 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

pleased to share our (with @dweisslab.bsky.social) News & Views perspective on this exciting paper
nam11.safelinks.protection.outlook.com?url=https%3A...

06.01.2025 17:20 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Enteropathogenic E. coli (EPEC) Transfers Its Receptor for Intimate Adherence into Mammalian Cells Enteropathogenic E. coli (EPEC) belongs to a group of bacterial pathogens that induce epithelial cell actin rearrangements resulting in pedestal formation beneath adherent bacteria. This requires the secretion of specific virulence proteins needed for signal transduction and intimate adherence. EPEC interaction induces tyrosine phosphorylation of a protein in the host membrane, Hp90, which is the receptor for the EPEC outer membrane protein, intimin. Hp90–intimin interaction is essential for intimate attachment and pedestal formation.

Discussed this awesome paper as a student years ago and still think about it www.cell.com/fulltext/S00...

13.12.2024 02:05 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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