Jan Hartmann, M.D.

Contemporary Operator Procedural Volumes and Outcomes for TAVR and MTEER in the US This cohort study determines whether an operator-level association of volume and outcomes exists for transcatheter aortic valve replacement (TAVR) and mitral transcatheter edge-to-edge repair (MTEER) ...

Contemporary Operator Procedural Volumes and Outcomes for TAVR and MTEER in the US url: jamanetwork.com/journals/jam...

Age-Adjusted D-Dimer Cutoff in Suspected Deep Vein Thrombosis This prospective management outcome study conducted at multiple centers in Belgium, Canada, France, and Switzerland assesses whether using an age-adjusted D-dimer cutoff allows clinicians to safely ru...

Age-Adjusted D-Dimer Cutoff in Suspected Deep Vein Thrombosis url: jamanetwork.com/journals/jam...

#anesthesiology #anesthesiologist #anesthesia #medicalresearch | Anesthesiology Journals A heparinase-containing cartridge for the TEG® 6s system to neutralize this effect was recently cleared by the U.S. Food and Drug Administration, but validation in clinical settings had been limited. ...

Our article on the trial of the HN cartridge for the TEG® 6s system featured in current issue of @anesthesiology.bsky.social.
A big thank you to our team of co‑authors, local PIs and their teams, and all the participating patients who made this possible.
www.linkedin.com/posts/anesth...

#teg6s #cardiacsurgery #patientbloodmanagement #hemostasis #medicalresearch | Haemonetics A multicenter study highlighted in Anesthesiology Journals clinically validated our TEG® 6s Global Hemostasis – HN cartridge by demonstrating high correlation with established assays in heparinized pa...

www.linkedin.com/posts/haemon...

Liberal or Restrictive Postoperative Transfusion in Cardiac Risk This randomized clinical trial tests whether a liberal compared with a restrictive transfusion strategy lowers the risk of a cardiac event 90 days after major vascular or general surgery among patient...

Liberal or Restrictive Postoperative Transfusion in Cardiac Risk
jamanetwork.com/journals/jam...

Preparing the Civilian Health Care System for Wartime This Viewpoint discusses the need for the US health care system to prepare for war casualties through military and civilian health care collaboration.

Preparing the Civilian Health Care System for Wartime url: jamanetwork.com/journals/jam...

Monoclonal gammopathy of undetermined significance is a common, asymptomatic plasma-cell disorder in older adults that can progress to cancer or systemic illness. Diagnosis warrants follow-up, but treatment is not required unless progression is confirmed. Learn more: nej.md/473uOsj

Transformative Research in Cystic Fibrosis | NEJM Michael Welsh, Jesús González, and Paul Negulescu have won the 2025 Lasker–DeBakey Clinical Medical Research Award for their roles in developing treatments for cystic fibrosis.

“For physician–scientists conducting early clinical trials, the results could best be described as miraculous.” 🧪
2025 #LaskerAward winners M. Welsh, J. González, & P. Negulescu developed life-saving #cysticfibrosis treatments. @nejm.org
#Lasker2025

Surprisingly Complex Assemblies from Low-Complexity Domains | NEJM Drs. Görlich and McKnight have won the 2025 Albert Lasker Award for Basic Medical Research for showing that low-complexity domains of proteins lack structure on their own and yet can form assembled .....

“The insights of Görlich, McKnight, and their colleagues are being harnessed in medical research.” 🧪
Read how low-complexity domains of proteins impact human health in @nejm.org
#LaskerAward #Lasker2025 @mpi-nat.bsky.social
#phaseseparation #biophysics
www.nejm.org/doi/full/10....

Soluble tissue factor generated by necroptosis-triggered shedding is responsible for thrombosis - Cell Research Cell Research - Soluble tissue factor generated by necroptosis-triggered shedding is responsible for thrombosis

www.nature.com/articles/s41...

Impact of Race on Profiles of Platelet Reactivity and Clinical Outcomes in Clopidogrel‐Treated Participants Black individuals undergoing percutaneous coronary intervention (PCI) experience higher rates of major adverse cardiovascular events (MACE) than non-Black individuals. This study assessed the racial ...

"Impact of Race on Profiles of Platelet Reactivity and Clinical Outcomes in Clopidogrel-Treated Participants"

ascpt.onlinelibrary.wiley.com/doi/abs/10.1...

Long-Term Outcomes of the DanGer Shock Trial | NEJM In patients with STEMI with cardiogenic shock, early mechanical support with a microaxial pump reduced the risk of death at 180 days, with the survival benefit persisting up to 10 years despite dev...

"Long-Term Outcomes of the DanGer Shock Trial"

www.nejm.org/doi/full/10....

Discontinuation of Anticoagulant Therapy After Catheter Ablation for Atrial Fibrillation This randomized clinical trial compares discontinuing vs continuing oral anticoagulant therapy in patients without documented atrial arrhythmia recurrence after catheter ablation for atrial fibrillati...

"Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation"

jamanetwork.com/journals/jam...

Clopidogrel versus aspirin for secondary prevention of coronary artery disease: a systematic review and individual patient data meta-analysis These findings add to the evidence that clopidogrel monotherapy is superior to aspirin monotherapy for MACCE prevention with no increase in the risk of bleeding, and support the preferential use of cl...

"Clopidogrel versus aspirin for secondary prevention of coronary artery disease: a systematic review and individual patient data meta-analysis" www.thelancet.com/journals/lan...

Study Reveals Caffeine May Undermine Blood Transfusion Effectiveness Study Reveals Caffeine May Undermine Blood Transfusion Effectiveness

Good thing I don't drink coffee...
news.cuanschutz.edu/news-stories...

In patients with heparin-induced thrombocytopenia, pathogenic antibodies were found to be monoclonal, which challenges previous views of HIT as a polyclonal disorder and suggests new avenues for diagnosis and treatment. Full study results: nej.md/4pkaYAq

#MedSky #CardioSky

Rainbow over Sandy Bay – Rockport, MA 🌈

Sex differences in dual antiplatelet therapy de-escalation strategies after percutaneous coronary intervention: a network meta-analysis AbstractBackground and Aims. Dual antiplatelet therapy (DAPT) de-escalation strategies improve outcomes after percutaneous coronary intervention (PCI) comp

Sex differences in dual antiplatelet therapy de-escalation strategies after percutaneous coronary intervention: a network meta-analysis url: academic.oup.com/eurheartj/ar...

A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery | NEJM Patients undergoing cardiac surgery often receive red-cell transfusions, along with the associated risks and costs. Early intraoperative normovolemic hemodilution (i.e., acute normovolemic hemodilu...

A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery | New England Journal of Medicine www.nejm.org/doi/full/10....

In the BATURA phase 3b trial, as-needed albuterol–budesonide resulted in a lower risk of severe asthma exacerbation than as-needed albuterol among participants with disease that was uncontrolled despite treatment for mild asthma. Full trial results and Research Summary: nej.md/43uVpwK

Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation | NEJM Transcatheter aortic-valve implantation (TAVI) is associated with procedure-related stroke. Cerebral embolic protection (CEP) devices may reduce embolization to the cerebral circulation and hence t...

Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation | New England Journal of Medicine www.nejm.org/doi/abs/10.1...

Later last night at #ISTH2025, we had the privilege of honoring a gentle giant of the field—Dr. | Jan Hartmann, M.D. Later last night at #ISTH2025, we had the privilege of honoring a gentle giant of the field—Dr. Hau Kwaan, MD, PhD, FRCP, FACP, Professor Emeritus at Northwestern University - The Feinberg School of M...

Last night at #ISTH2025, we honored a gentle giant—Dr. Hau Kwaan, Professor Emeritus at ⁦‪⁦‬⁩Northwestern. A true #Fibrinolysis pioneer with 400+ articles since the 1950s—still contributing posters in his 90s. Thanks, Mark Walsh, for a moving laudatio.
@isth.org
www.linkedin.com/posts/janhar...

Opinion | It’s Code Red for Vaccines in America (Gift Article) How to make sense of all the vaccine policy changes.

It’s Code Red for Vaccines

The number of changes to vaccine policy is dizzying & RFK Jr is just getting started!

Dissolving the group of experts that drive policy is declaring war on “what was”

I write in @nytimes.com about what is and is not working

www.nytimes.com/2025/06/11/o...

This tiny device can shrink dangerous blood clots. It’s called the ‘milli-spinner’ and its invention was partly an accident…

NHS calls for 200,000 new blood donors as supplies run low The health service issued an "amber alert" last year and stocks remain low ever since.

bbc.com/news/article...

2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP url:https://academic.oup.com/ejcts/article/67/5/ezae352/7815985

Public radio in Boston… 📻 ⁦‪ ⁦‬⁩ #BumpaSticka @npr.org @wbur.org

Bruins turn to ex-forward Sturm as head coach The Boston Bruins hired Marco Sturm as coach on Thursday to help the Original Six franchise get back to the playoffs after missing them for the first time since 2016.

🇺🇸 🇩🇪 www.espn.com/nhl/story/_/...

Platelet Transfusion International Clinical Practice Guidelines This Special Communication discusses the updated Association for the Advancement of Blood and Biotherapies and the International Collaboration for Transfusion Medicine Guidelines international clinica...

jamanetwork.com/journals/jam...

If you read one thing today, make it this: an epochal speech by the German President on the occasion of the 80th anniversary of Germany's capitulation at the end of WW2.

www.bundespraesident.de/SharedDocs/R...