Thomas Robert

CKDx is a good start - But can we go further? Presented by Laurent Mesnard Article DOI: https://doi.org/10.1093/ndt/gfaf138

💡 CKDx is a good start — but can we go further?

Réflexion sur les forces et limites de la classification CKDx, et comment pousser plus loin la médecine de précision en néphrologie.

🎥 oup.cloud.panopto.eu/Panopto/Page...

#Nephrology #Genomics #CKDx #PrecisionMedicine

A timely and beautifully structured piece! As a nephrologist leading a clinical genomics unit in France, I strongly resonate with your call for a new kind of specialist who can bridge genomic data with kidney medicine.

CKDx: a necessary step—but can we go further? Thomas Robert, Mathieu Georget, Yannis Lombardi, Laurent Mesnard; CKDx: a necessary step—but can we go further?, Nephrology Dialysis Transplantation, , gfa

CKDx: a necessary step—but can we go further? url: academic.oup.com/ndt/article/... @nephroseeker.medsky.social

Very interesting paper ! Effect of haemodialysis on the brain and heart assessed using multiparametric MRI url: academic.oup.com/ndt/article/...

Before escalating immunosuppression, a repeat biopsy might help clarify the benefit-risk balance. With rising creatinine despite lower proteinuria, it’s key to know if we’re treating activity—or just chronic damage.

Nephrogenomics, precision medicine and the role of genetic testing in adult kidney disease management - Nature Reviews Nephrology This Review examines the use of pangenomic analysis to improve molecular diagnoses in adult nephrology, including available sequencing methods and their applications. The authors also discuss current ...

🧬 Notre Review sur la néphrogénomique chez l’adulte vient de paraître dans Nature Reviews Nephrology !
➡️ Nous y explorons comment le séquençage reconfigure le diagnostic des néphropathies d’origine indéterminée.
@laurentmesnard
📖 : doi.org/10.1038/s415...

🥝 Le potassium ne fatigue pas les reins
🚦Mais en cas de maladie rénale, il peut devenir un vrai danger s’il s’accumule.
🟢 Modéré 🟡 À surveiller 🔴 À limiter sévèrement
🍌 🍫 🥝 🍅 🥔… Apprenez à les repérer !
📄 Une fiche claire et pratique.
📥 -->: www.hopital-saint-joseph.fr/image/10579/...

How hyperkalemia affects the heart: clinical implications Hyperkalemia is a common and potentially life-threatening electrolyte imbalance, especially in patients with chronic kidney disease or in those on medicati

Distinct ECG signatures of hyperkalemia in AKI versus CKD have important clinical implications. Read the full paper here: academic.oup.com/ndt/article/...
#Nephrology #Hyperkalemia #ECG #KidneyDisease

🔬 Dernière Newsletter Néphrogénomique disponible !
✅ Taux diagnostique trimestriel : 24% 📊
✅ Focus sur les collagénopathies de type IV et l’évolution du concept de syndrome d'Alport 🧬 (COL4A3, COL4A4, COL4A5) #nephrogénomique
www.eurofins-biomnis.com/DOC-Biomnis/...

Oui, l’écart CSP est réel. Mais les catégories INSEE sont assez larges, ne captent pas toute la vulnérabilité sociale. Les données pointent aussi des surmortalités bien plus marquées chez les enfants de familles immigrées ou en grande précarité. Je trouve que c’est complexe que « cadre vs ouvrier ».

C’est sûr, si on pouvait régler la mortalité infantile en opposant ouvriers et cadres, ce serait simple. Mais la réalité, c’est qu’on réanime très tôt en France, un choix éthique qui plombe nos stats. Les inégalités touchent surtout les plus précaires, pas juste les catégories de l’INSEE

Infant mortality among native-born children of immigrants in France, 2008–17: results from a socio-demographic panel survey AbstractBackground. Within Europe, France stands out as a major country that lacks recent and reliable evidence on how infant mortality levels vary among t

Et un autre sur le point socio économique : academic.oup.com/eurpub/artic...

Un premier element qui peut aider à y voir plus clair : www.insee.fr/fr/statistiq...

Many adult patients with chronic kidney disease still lack a diagnosis. Nephrogenomics bridges that gap — combining clinical nephrology with genomic sequencing (short & long reads) to identify inherited kidney diseases. Precision medicine starts here. #Nephrogenomics #CKD #Genetics

Prudence avec ces chiffres : la France réanime très activement les grands prématurés, augmentant mécaniquement sa mortalité infantile comparée à d'autres pays européens. La vraie alarme reste les fortes disparités sociales et les populations précaires ou immigrées.

ACE Inhibition to Distinguish Low-Renin Hypertension From Primary Aldosteronism | Hypertension BACKGROUND: Primary aldosteronism (PA) is a distinct cause of low-renin hypertension (LRH), characterized by inappropriate aldosterone production. We investigated the distinction between LRH and PA by...

ACE Inhibition to Distinguish Low-Renin Hypertension From Primary Aldosteronism
#nephsky
www.ahajournals.org/doi/10.1161/...

Challenging the narrative of alport syndrome spectrum: no link with cystic phenotype - PubMed A 14.8% prevalence of MKC was found in our cohort of 257 patients with AS. MKC-AS patients exhibited clinical and histological characteristic akin to nephroangiosclerosis. Our comprehensive analysis, ...

There is contradictory data for collagen —> pubmed.ncbi.nlm.nih.gov/39694697/

Artesunate Alleviate Kidney Fibrosis by Restoring Klotho Protein and Suppressing Wnt/β-Catenin Signalling Pathway https://www.biorxiv.org/content/10.1101/2025.03.20.644310v1

Having a fabulous Bluesky day in Japan! Trip to Minamata with team #Alport & family @moumitabarua.bsky.social @jeffminerphd.bsky.social @alportuk.bsky.social

Beneficial Effect of Calcium Treatment for Hyperkalemia Is... : Critical Care Medicine P). However, the underlying mechanisms remain poorly understood. Our objective was to investigate the mechanisms underlying adverse electrophysiologic effects of hyperkalemia and the therapeutic effec...

Hard to say calcium is ineffective for hyperkalemia with conduction issues when your review focused only on cardiac arrest. This study [Piktel et al., CCM 2024] shows Ca²⁺ improves conduction in severe Hyperkalemia. A must-read! 📄🔗
journals.lww.com/ccmjournal/a...

Pseudo-hyperkalaemia in ambulatory samples: the never-ending story? Hyperkalaemia is a major electrolyte disturbance, which can be life-threatening [1, 2]. Pseudo-hyperkalaemia has been described since 1955 but remains a fr

In real life, recognizing pseudo-hyperkalemia risk is key! Home sampling, transport delays, and temperature impact results. 🚨 --> academic.oup.com/ndt/article/...

Our February Nephrogenomic Newsletter is out!
Note: This newsletter is in French – my apologies to our anglophone colleagues.
@laurentmesnard @biomnis @HopitalSaintJoseph
Read the full newsletter here: --> www.eurofins-biomnis.com/DOC-Biomnis/...

Challenging the narrative of alport syndrome spectrum: no link with cystic phenotype AbstractBackground. Alport Syndromes (AS) are the second leading genetic cause of Kidney Failure (KF). Whether multiple kidney cysts (MKC) phenotype belong

The proof is in the data: academic.oup.com/ndt/advance-...
Cysts are not caused by Alport syndrome, though patients with Alport syndrome can have cysts.

Somehow missed this excellent VA of the RaDaR study that has changed hearts and minds in IgA Nephropathy, breaking the sound barrier of 1g/day of proteinuria as are standard for high risk of progression

Challenging the narrative of alport syndrome spectrum: no link with cystic phenotype AbstractBackground. Alport Syndromes (AS) are the second leading genetic cause of Kidney Failure (KF). Whether multiple kidney cysts (MKC) phenotype belong

Collagenopathy is not a so rare disease—it just has a broad and poorly specific phenotype. academic.oup.com/ndt/advance-...