Tim Julian

According to this paper, 8+ hours is adequate: "severe inadequate ...4.7 to 4.1 hours per night... moderate inadequate... (6.0 to 5.5 hours per night... , mild inadequate... 7.2 to 6.8 hours per night... and adequate... 8.4 to 8.0 hours per night."

Swiss wastewater - RSV GenSpectrum is an interactive dashboard to query and analyze pathogen sequences, currently available for Influenza H5N1, RSV, SARS-CoV-2 and the West Nile virus.

Check out the website here: genspectrum.org/swiss-wastew.... And follow our work tracking virus loads in #RSV here: wise.ethz.ch. We're still in the middle of an #RSV wave now, but it looks like the peak may be behind us.

So now back to our work sequencing #RSV, available from #Genspectrum website: We can track genomic changes in virus regions targeted by #Nirsevimab and the vaccines, to detect, within the population, whether or not the virus mutates in ways that may confer resistance to our available treatments.

But the good news is, in #Switzerland, we have monoclonal antibody Nirsevimab for infants to reduce risks of severe disease, or as a prophylaxis to prevent infections in at-risk infants. We also have two vaccines against #RSV approved for the elderly: www.bag.admin.ch/bag/en/home/...

RSV: Wegen diesem Virus sind die Kinderspitäler überfüllt Wegen des sogenannten Respiratorischen Synzytial-Virus (RSV) müssen immer mehr Kleinkinder und Säuglinge in der Schweiz im Spital behandelt werden.

«Wir haben momentan keine Reserve mehr an freien Betten mit pflegerischer Betreuung.» Christoph Berger said at the time, as reported in @20min.ch www.20min.ch/story/wegen-...

Another number that's important is #hospitalizations. #CDC estimates 130-260k hospitalizations in the #US. These are infections severe enough to require a hospital bed, which means that bed is not available for other illnesses. In 2022-23, #Switzerland, a huge RSV wave impacted hospitals...

#RSV is a common #respiratory virus. We've probably all had it at some point in our life. For most of us, its a nuisance* But for some people, including #children and the elderly, its deadly. #CDC reports an estimated 7k-16k deaths due to RSV this season alone. www.cdc.gov/rsv/php/surv...

Swiss wastewater - RSV GenSpectrum is an interactive dashboard to query and analyze pathogen sequences, currently available for Influenza H5N1, RSV, SARS-CoV-2 and the West Nile virus.

We are tracking mutations of #RSV in #wastewater: genspectrum.org/swiss-wastew.... Why this matters and why you should re-tweet for visibility (a 🧵).

The highest incidence rates of upper #Respiratory diseases is in children under 2 years old, again from The Lancet. www.thelancet.com/journals/lan...

Global, regional, and national burden of upper respiratory infections and otitis media, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021 The findings of this study highlight the widespread burden posed by URIs and otitis media across all age groups and both sexes. There is a continued need for surveillance, prevention, and management t...

As #Respiratory #Disease peaks in #Switzerland, a few notes. More than 12.8 billion upper respiratory infections are estimated globally every year, that's >1 per person per year! See www.thelancet.com/journals/lan...

#Wastewater in #Switzerland showing high levels of circulating #RSV, #InfluenzaA, and #InfluenzaB. A lot going around at the moment. See our dashboard at wise.ethz.ch, or the FOPH Infectious Disease Dashboard for integrated surveillance at idd.bag.admin.ch

Trump's DEI order leaves academic researchers fearful of political influence over grants President Donald Trump’s order declaring diversity, equity and inclusion policies illegal has thrown into doubt the future of research Kendra Dahmer has been doing on intestinal parasites in India and...

Postdoctoral scholar Dr. Kendra Dahmer discusses how the new administration's policies could affect her global health research apnews.com/article/trum...

"New infections in children were associated with preceding household detection of the same pathogen in soil (Odds ratio: 8.8, 95% confidence interval: 3.3, 23) and on child hands (Odds ratio: 5.0, 95% confidence interval 1.1, 17)."

📯 #Swiss wastewater dashboard through our #wise project is now updated with historic data within which you can overlay the seasons. #Influenza B is now high, after skipping a year. Check it out here: wise.ethz.ch

#Wastewater-based monitoring for #PublicHealth holds a lot of promise, but an outstanding challenge is to understand what public health relevant metrics can be derived, and how we translate data into impact. See our Viewpoint on #AMR #AntimicrobialResistance in #EST 👇

Quantification of Legionella pneumophila in building potable water systems: A meta-analysis comparing qPCR and culture-based detection methods Quantitative polymerase chain reaction (qPCR) offers a rapid, automated, and potentially on-site method for quantifying L. pneumophila in building potable water systems, complementing and potentially ...

If you're measuring #Legionella in a water system using qPCR, how do you relate your value to culture? We suggest a conservative 1:1 assumption! Unless you know more about your system, this seems accurate based on a systematic review. Led by Emile Sylvestre: journals.plos.org/water/articl...

The mutation impacts the digital PCR efficiency, resulting in an underestimate of the concentration (for N1). As a consequence, we now monitor the ratio as part of our weekly QA/QC. We observe some fluctuation from week to week, but the ratio has returned back to 1.

covSPECTRUM covSPECTRUM is an interactive platform aiming to help scientists investigate and identify variants of SARS-CoV-2.

We observed a decoupling in the ratio consistent with a mutation in the forward primer region, which increased and then decreased throughout 2023: cov-spectrum.org/explore/Swit...

Yes, we have data from mid-2022; we're working on updating our database to include older data, it should be up in a week or two.

From the #Swiss #Wastewater, signs of #SARS-CoV-2 receding, while both #influenza A and B continue an upward rise. #RSV looks to be staying stable, could be evidence that it has peaked. From: wise.ethz.ch

Everything is everywhere all at once: #Influenza A, Influenza B, and #RSV are all increasing in #Zurich wastewater, while #SARS-CoV-2 still circulates. From wise.ethz.ch.

Thanks for the digest, @elife.bsky.social 💥
How to combat pathogenic bacteria through iron starvation:
Read more ⬇️
#AMR #Siderophore

Here's the visual proof of why vaccines do more good than harm See year by year how vaccines beat back nine dangerous infectious diseases

Sadly, it’s a good time to once again share this amazing infographic that we ran at @science.org more than 7 years ago
🧪 #IDsky
www.science.org/content/arti...

Design, validation and implementation of multiplex digital PCR assays for simultaneous quantification of multiple targets Abstract. Quantitative PCR (qPCR) and digital PCR (dPCR) are applied for quantifying molecular targets in disease diagnostics, pathogen detection and ecolo

we've been working on multiplex #dPCR assays the last few years, and here are a few things we've figured out along the way. Lead by Jolinda de Korne-Elenbaas: academic.oup.com/lambio/advan...

College students get emotional about climate change. Some are finding help in class A recent survey finds that more than half of young people aged 16-25 are highly worried about climate change. Some universities are now trying to help them navigate those emotions in class.

interesting article about making teaching about climate change personal to students at @cornelluniversity.bsky.social, from @npr.org. www.npr.org/2024/12/22/n...

Wastewater monitoring meets with great interest Today, over 60 experts from research, federal and cantonal administration, the police, politics and hospitals are meeting to discuss the current status and future of wastewater monitoring in Switzerla...

💡 "Every time we think it's becoming routine, something new comes along."

Read our interview with Christoph Ort, who, together with @trj2.bsky.social, established the field of wastewater-based epidemiology at Eawag 💧🔬

👉 www.eawag.ch/en/info/port...

Clear signs in wastewater that RSV season is picking up as we enter end of year holidays. In past years, RSV has picked up before Influenza A and B. From: wise.ethz.ch.