Jorge Domínguez Andrés

Off-target beneficial effect of live-attenuated herpes zoster (shingles) vaccine (Zostavax).

#IDSky #vaccination

Today, I dropped my phone on the street while cycling to work. Luckily, a kind soul found it and took it with her to her workplace so I could pick it up. That kind soul turned out to be my department director, @middeldorps.bsky.social. What were the chances? Many thanks!

This. We need to stop the fever of needing lots of preliminary data in grant applications.

Friends to remember: innate immune memory regulation by the microbiota Innate immune memory (IIM) is the process by which, upon a primary challenge, innate immune cells alter their epigenetic, transcriptional, and immunom…

📃Friday publication alert!

Our latest review paper
"Friends to remember: innate immune memory regulation by the microbiota" Trends in Microbiology @cp-trendsmicrobiol.bsky.social

Brief paper tutorial below 👇

@anguitalab.bsky.social @cicbiogune.bsky.social
www.sciencedirect.com/science/arti...

An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses, but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this q...

📢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc Eloïse Marques. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n
www.biorxiv.org/content/10.1...

Si hay que interactuar, se interactúa

"A study of federally funded research projects in the United States estimated that principal investigators spend on average about 45% of their time on administrative activities related to applying for and managing projects rather than conducting active research"

www.pnas.org/doi/10.1073/...

Thanks, sure thing!

Not this year, I had a child half a year ago and that's too far from home now!

Funny Elephant Toothpaste (Chemical Reaction) YouTube video by DIY bama

I'd say try to make something practical, individually or in pairs. They will not listen to you at all if they just sit down! Sth like a DNA extraction or the elephant toothpaste: youtu.be/p5qvi20J5IM?...

Pls RT. The organizers of #GDTcellclub webinar series are looking to welcome new #GDTcell scientists to join the team. Pls comment below to be added to the upcoming informational meeting. Looking for driven grads/postdocs/faculty to join us in keeping this platform alive. @forum-gd.bsky.social

Apollo astronauts left their poop on the moon. We gotta go back for that shit. What 50-year-old dirty diapers can teach us about the potential origins of life on Earth.

Attended a beautiful talk by @dominjor.bsky.social at the @cnb-csic.bsky.social workshop for young scientists abroad. We think of Earth as the only place in Universe with life, but... did you know astronauts left 96 bags of 💩 on the Moon? Who knows what 🦠 are there now!
www.vox.com/science-and-...

Thanks! 😁

Cool! Can I be added as well?

There's still time to apply for this postdoc position in our lab. Ideally suited to someone wanting to develop some independent research, we have lots of new projects to select from! #immunosky 🧪

On Thursday 19th, I will be back to @cnb-csic.bsky.social 7,5 years later to give a talk about the work we have been conducting since I left. If you are around and want to talk about evolution, metabolites and space... don't miss it!🚀

Breaking news: Enterococcus faecalis just got promoted from 'gut squatter' to 'immune system personal trainer.' Turns out this bacteria can journey to the bone marrow and whip your immune cells into shape. Gut bugs: sometimes freeloaders, sometimes coaches. 🦠💪 #MicrobiomeMagic

Translocation of gut Enterococcus faecalis trains myeloid bone marrow progenitors via the C-type lectin receptor Mincle Impairment of the intestinal barrier allows the systemic translocation of commensal bacteria, inducing a pro-inflammatory state in the host. To address potential mechanisms underlying this link, we ex...

What is the effect of increased bacterial dissemination in distant organs?
Check our www.biorxiv.org/content/10.1...
1 Gut barrier disruption induces trained immunity in bone marrow progenitors
2 Enterococcus faecalis translocates to the bone marrow inducing trained immunity

Publishers are selling papers to train AIs — and making millions of dollars Generative-AI models require massive amounts of data — scholarly publishers are licensing their content to train them.

Did we scientists authorize this in the licensing conditions?

www.nature.com/articles/d41...

Siete pasajeros y al menos 15 navajas

"Vendo Opel Corsa"

Only when you pay very substantial APC

Awesome, I would like to be added, thanks!

Can I also be added? Thanks!

The corresponding LinkedIn post raised a very active discussion who reached >40000 people (www.linkedin.com/feed/update/...). From that discussion, I would like to highlight the following points (see image). These remained unanswered by the ERC, though they have seen them.

A couple of weeks ago, I wrote written a letter published in @natureportfolio.bsky.social
discussing the disparities in the ERC's parental leave policies for fathers across Europe. We must address these issues to promote equality in research careers:

www.nature.com/articles/d41...

Yes, got a kid a couple of months ago so I'm living on the edge of sleep, but doing well! Hope you are too, I'll try to go to the Aegean next year, I had to skip last one!

Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation Sur Chowdhury et al. report that Mycobacterium tuberculosis (Mtb) infection results in the release of neutrophil extracellular traps (NETs) that promote Mtb replication and associate with tissue damage. Blocking NET release results in better control of Mtb replication, revealing a strategy for treating these deadly infections.

Very excited for this story to be out!! Check out our dissection of how type I IFN promotes NET release, which contributes to Mtb pathogenesis and is associated with granuloma necrosis. Congratulations to all authors!! www.cell.com/cell-host-mi...

Awesome, congratulations!

Focus Issue: Call for papers in Trained Immunity After a decade of research into innate immune memory, we are pleased to launch a call for papers in trained immunity addressing what we have learned and what’s next for the field.

Remember you have until February 28th to join the call for papers for our special Trained Immunity issue on @elife.bsky.social!

elifesciences.org/inside-elife...