Kara Margolis

A gut sense for a microbial pattern regulates feeding - Nature A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.

New research reveals that the gut can sense microbial flagellin via TLR5-expressing neuropod cells, triggering PYY release & reducing feeding through a gut–brain neural circuit—independent of microbiota or immune cues.
@karapedsgastrodoc.bsky.social

🔗 www.nature.com/articles/s41...

@chalysthalee.bsky.social did an amazing job presenting at the ISSR! Such a well-deserved travel award and so proud to have her representing the lab!!

Upper-gastrointestinal tract metabolite profile regulates glycaemic and satiety responses to meals with contrasting structure: a pilot study - Nature Metabolism In this randomized crossover pilot study, the authors collected human gastrointestinal digesta using a unique intubation technique to compare how meals with contrasting cellular structures affect post...

A new study shows that food structure plays a key role in determining which gut hormones are released.
@karapedsgastrodoc.bsky.social

#GLP1 #GutBrainAxis #FoodStructure #Type2Diabetes #ImperialCollege

📖 Nature Metabolism
www.nature.com/articles/s42...

Blood-based T Cell Diagnosis of Celiac Disease Current diagnosis of celiac disease (CeD) is inaccurate in patients following a gluten-free diet (GFD). Blood-based diagnostics targeting gluten-speci…

🩸 A new blood test (WBAIL-2) detects gluten-triggered IL-2 release, offering a non-invasive, accurate way to diagnose celiac disease, even in patients on a gluten-free diet! 🌾❌
Game-changer for gut health.
sciencedirect.com/science/arti...

#guthealthmatters #WBAIL2
@karapedsgastrodoc.bsky.social

Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior.
buff.ly/caKMGY3

NSF, NASA and NIH budgets per year, inflation adjusted from 2000-2025 along with the proposed cuts. NSF includes research component only. Massive cuts across all sectors, well below support spanning 25 years.

How bad will it be? Catastrophic.

Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come.

But, this is the WH's *proposed* budget.

Speak up now before it is too late.

(inflation adjusted $-s below)

I will always think of astringency now when I drink wine!😂

🎤 BLINK AND YOU'LL MISS IT: FLASH TALKS AT THE 5TH ANNUAL AMPIRS! ⚡ This year’s Flash Talks were a whirlwind of brilliance 🎤one mic, infinite insight. And WOW, did our presenters deliver! 👏PRC representing! #PRCpride #violetpride #NYUDental #nyuniversity

Round two- ding ding! 🥊 Time for an AMPIRS photo dump that’ll knock your lanyard off 😎🚨poster session 2 coming in 🤳📸 picture perfect!👌

And just like that, AMPIRS takes its final bow! 🎬Huge cheers to our grand finale presenters and a confetti cannon 🎉 of congrats to all the Flash Talk, Poster and Oral Presentation champs! 🏆 You dazzled, you delivered, you definitely deserve it! #PRCpride #MPBpride

Curtains down on AMPIRS! Dr. Nigel Bunnett, our MPB Chair, brought it home with closing remarks. Huge thanks to our amazing sponsors and a special shoutout to MPB for hosting AMPIRS & Welcoming the Pain Research Center into the fun! And now… cue the real research question: Wheres happy hour? 🍹😄

Aging and injury drive neuronal senescence in the dorsal root ganglia - Nature Neuroscience The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.

New study! Aging and nerve injury cause senescent neurons in the peripheral nervous system, driving increased pain; targeting these cells could offer a new pain treatment especially in older adults.
@vivtawfik-mdphd.bsky.social
@karapedsgastrodoc.bsky.social
www.nature.com/articles/s41...

The IL-18 receptor is expressed on murine small-intestinal enterochromaffin cells and executes a recovery program upon injury | PNAS Upon injury, epithelial-derived IL-18 is released and induces an inflammatory response in underlying IL18R1+ lamina propria cells. Notably, Il18r1 ...

IL-18 signaling in epithelial-derived enterochromaffin cells plays a pivotal role in injury response and stem cell activation in the mouse intestine #gutresearch #epithelialcells #IL18 #stemcells
@karapedsgastrodoc.bsky.social
www.pnas.org/doi/10.1073/...

NYU Pain Research Center

@karapedsgastrodoc.bsky.social @margolislabnyu.bsky.social @amergastroassn.bsky.social PRC Website: dental.nyu.edu/research/pai... Margolis Lab: dental.nyu.edu/faculty/mole...

Yes! Your taste buds do talk to your brain🧠! Thank you Dr. Nirupa Chaudhari for a fantastic talk! #brain #NYUdentistry #PRC

Tea 🫖 Time ⏰! Happy monthly birthday shoutout! #PRC #NYUdentistry #NYU #MPB 🎂🥳🎈#happybirthday

Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients With Head and Neck Squamous Cell Carcinoma: A Cross‐Sectional Observational Study Background This exploratory cross-sectional observational study sought to characterize sleep quality and evaluate its association with sociodemographic, clinicopathological, behavioral, and psycholo...

A new study with Dr. Yi Ye as a co-author "Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients with Head and Neck Squamous Cell Carcinoma: A Cross-Sectional Observational Study" #Pain #Anxiety #Depression #HNSCC onlinelibrary.wiley.com/doi/full/10....

Visual exposure to green light therapy reduces knee joint... : PAIN cytokines in the cerebrospinal fluid. The present study assessed the effect of green light therapy (GLT) on joint pain in a rat model of osteoarthritis (OA) and investigated the role of endolipids. Ma...

Green light for pain relief! 🟢 Researchers found green light therapy reduced osteoarthritis pain in rats, via analgesic endolipids engaging the endocannabinoid system. #PainResearch #GreenLight #Osteoarthritis journals.lww.com/pain/fulltex...

@badrsokrat.bsky.social

🚨Sound the alarm- it’s an AMPIRS photo dump! 🚨Poster Session 1 brought the heat 🔥 Big shoutout to our amazing PRC members who rocked their posters! #NYUDental #nyuniversity #AMPIRS #Painresearchcenter

#PRC Highlight: Happy Flash back Friday! Flashing Back to Cinco De Mayo! 💃🕺🏼🪇 MPB Tea Time always celebrating in style! #PRCpride #teatime #🫖 #cincodemayo #flashbackfridays #thankyou #PRC

A prolactin-targeting antibody to prevent stress-induced peripheral nociceptor sensitization and female postoperative pain | PNAS Scheduled surgeries elicit stress in many patients. Levels of preoperative stress, anxiety, and female gender are known risk factors for increased ...

New research reveals prolactin as a driver of stress-induced post-surgery pain in women. Blocking prolactin shows promise for better pain management & reduced opioid use! #PostoperativePain #Prolactin #PainResearch www.pnas.org/doi/10.1073/...

Great talk given to the PRC PRIMED Club by guest speaker Manon Bohic on Spinal Oxytocin Modulates Touch Reward and Pain Relief Through Shared Dorsal Horn Circuits. Manon Bohic is a research associate at Rutgers University.👏 #Thankyou for the visit! #SpinalDorsal #PRC #womeninscience

Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain G-protein-biased agonists have been shown to enhance opioid analgesia by circumventing β-arrestin-2 (βarr2) signaling. We previously reported that SBI…

💡 A promising non-opioid strategy—SBI-810 reduces pain, opioid reward, withdrawal, and constipation through selective β-arrestin-2 signaling www.sciencedirect.com/science/arti...

A big shoutout to Nikhil Sharma for joining our MPB Seminar Series! 🙌 @nyupainresearch.bsky.social loved your fascinating deep dive into the enteric nervous system and its connection with peripheral sensory & autonomic ganglia. 👨‍🔬🧠✨ #Neuroscience #PainResearch #MPBSeminar

Special thanks from the #painresearchcenter to @shuibingchen.bsky.social for sharing a talk on Human Pluripotent stem cells, disease modeling and drug screening. Amazing job hosting #DrEdwinRosadoOlivieri! #ChenShuibing #HumanPluripotent #PRC #thankyou!

Congrats @adesgeorges.bsky.social

Estimates of Illicit Opioid Use in the US This cross-sectional survey study estimates the prevalence of illicit opioid use, including illicitly manufactured fentanyl, and initial opioid exposure among those reporting illicit opioid use.

New study reveals alarmingly high rates of illicit opioid and fentanyl use in the US, much higher than prior estimates, underscores the urgent need for better data to fight the opioid crisis. #OpioidCrisis #Fentanyl #PublicHealth jamanetwork.com/journals/jam...

PRC Highlight: Welcome to the PRC-Structural Biologist Dr. Halil Aydin and Dr. Nestor Jimenez-our Director of the PRC e-phys core!! We are so excited to have you join the team! 👏🥳🎉

Incredibly excited to work with our new neighbors in the Hi bell lab!!