brian_delisle

Yes, you can see the other submitted reviews after the due date.

Congrats!!!! You are doing amazing work - generating new knowledge!

Congratulations Abhilash- You are doing great research and doing so much hard work! Didn’t you just do a 2-day circadian collection earlier this week?

🚨 🆕 🔬 💥 Suzuki et al reveal Kir2.1 channels hyperpolarize macrophages, crank up CRAC channel–mediated Ca²⁺ entry ⚡and migration w/o touching phagocytosis or M2 polarization 🧫 It’s all about that K⁺ flow and CaMK–Pyk2 activation🧠🔥#Physiology #IonChannels
👉 journals.physiology.org/doi/full/10....

Asprosin attenuates diabetic cardiomyopathy through inhibiting autophagy mediated by AMPK/mTOR/ULK1 pathway | American Journal of Physiology-Cell Physiology | American Physiological Society Aberrant autophagy mediated by AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/unc-51 like kinase 1 (ULK1) pathway (a canonical autophagy pathway) plays important roles in dia...

🚨 🆕 🫀🔬🔥 Wang et al: Asprosin 💥 protects the diabetic heart by dialing down overactive autophagy via the AMPK/mTOR/ULK1 pathway 🧬 No Asprosin = more fibrosis & more apoptosis 😱 💉🧠 #CardioSky #Physiology #autophagy
👉 journals.physiology.org/doi/full/10....

🚨 🆕 🔬 Pereira Jr. et al. show that MitoKATP channels are vital for brown adipocyte 🔥 growth—but are switched off for thermogenic blast 💥 in mature cells. Cold? NE? Block the channel, burn the fuel. ❄️🧬 👉 journals.physiology.org/doi/abs/10.1...
#IonChannels #Physiology

🚨 🆕 🔬 Melgari et al show widely used “WT”cardiac🫀Na+ channel (SCN5A, Nav1.5) clone carries the rare T559A variant 🧬. T559A shows loss-of-function, halved Na+ current, & altered kinetics 🧪 👉 journals.physiology.org/doi/abs/10.1...
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky

🚨 New 💪 🔬 Naughton et al. reveal NOMO as a force-bearing ER protein that shapes ER structure & drives muscle cell fate—Its Ig-domain handles piconewton-scale tension, delete it, and myogenesis breaks down 🧬
🔧👉 rupress.org/jcb/article/...
#Physiology #Cell #Science #Muscle

Bhlhe40 (a known negative regulator of BMAL/CLOCK activity) as a transcriptional activator of SMC-to-foam cell transition in #Atherosclerosis

Ldlr-/- Myh11-CreERT2 ROSA26-ZsGreen1🐭
CITE-seq (119 Ab)

Only 1~3% (Not 30%!) Mφ-like cells are SMC-derived 🤓

bioRxiv 2025
www.biorxiv.org/content/10.1...

Cross-Talk of Cells in the Heart 2025: Novel Mechanisms of Disease and Arrhythmias Cross-Talk of Cells in the Heart 2025, an exciting two-day meeting at University of Birmingham (UK) to discuss the latest breakthroughs in cardiac arrhythmia and disease research. Join us

📢 Final call! Submit your abstracts to present your research at our meeting, ‘Cross-Talk of Cells in the Heart 2025’ at the University of Birmingham on 3-4 Sept. Showcase your findings on the mechanisms of heart disease and arrhythmias.

📝 Submit by 2 June ⬇️

Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia Ducharme et al. investigate the impact and crosstalk between cancer and FoxP1 on the skeletal-muscle circadian transcriptome that mediates time-of-day-dependent biological functions. They reveal cance...

Its taken a few years but finally had science fun collaborating with @andyjudge24.bsky.social, @sarahjudge.bsky.social and the talented postdoc @jbducharme.bsky.social with support from Miguel Gutierrez-Monreal. Cancer and the muscle clock. 1/ www.cell.com/cell-reports...

Graphical abstract - cell mechanics, histology and western blots.

Excited to see (newly Dr) Greg Milburn's paper on cardiac amyloidosis in human myocardium with cell-level mechanics, histology, and gel-based analysis of sarcomeric proteins.

Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis
doi.org/10.1016/j.ja...

We are very pleased to share that our paper on sexual dimorphism in circadian rhythms has been published in @plosbiology.org. This work was led by the very talented Aishwarya Iyer and includes contributions from three undergraduate co-authors.

You can read the full study here:

For the last 3 yrs, I was the director for the Science of Science program at the NSF. We funded projects on science communication - science communication to the public, communication of public priorities to scientists, citizens engagement & participation in science. 🧵

Please read this.

GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15

#FreeToRead 👀

CONGRATULATIONS!

An ovary-intact #postmenopausal #HFpEF mouse model; #menopause is more than just #estrogen deficiency
Mei Methawasin, et al.

➡️doi.org/10.1152/ajph...

David J Paterson of @oxforddpag.bsky.social & Kalyanam Shivkumar of @uclaupdates.bsky.social present this preface #Editorial for our latest special issue 'Cardiac Neurobiology: Concepts to Clinic' which is dedicated to Jeffrey L. Ardell (1952–2025)

📜 physoc.onlinelibrary.wiley.com/doi/full/10....

Diet-induced obesity dampens temporal oscillation of hepatic mitochondrial lipids

Our study revealed that obesity altered the mitochondrial lipid composition & hampered the rhythmicity of mitochondrial lipids, oxygen consumption rate & Parkin levels in liver
www.sciencedirect.com/science/arti...

🔓Editorial From Timothy Musch et al.

“APS Initiatives and Milestones: a Year in Review and a Look Ahead”

➡️doi.org/10.1152/phys...

🚨🆕🔬Eosinophil clocks disrupted with asthma? Teppan et al show that disrupted circadian clocks in eosinophils fuel airway inflammation 🫁 Resetting the clock with a ROR inhibitor ⬇️ mucus, ⬆️ lung function👉 journals.physiology.org/doi/pdf/10.1...
#Physiology #Science #Circadian #Asthma

Opinion | Actually, A.I. Is Pretty Mid (Gift Article) A.I. is just what we need in the post-fact era: less research and more predicting what we want to hear.

Unsurprisingly, @tressiemcphd.bsky.social is spot-on in this analysis: “A.I.’s most revolutionary potential is helping experts apply their expertise better and faster. But for that to work, there has to be experts.”
www.nytimes.com/2025/03/29/o...

Common hallmarks and potential mechanisms linking cancer, circadian rhythms, and aging.

•Night shift work is associated with increased inflammation
•HDL-C levels are decreased among night shift workers
•Night shift workers have prolonged heart rate-corrected QT intervals
•HDL-C & QTc are promising indicators of CVD risk among night shift workers
www.sciencedirect.com/science/arti...

For a presentation I am giving, I made a wordcloud of the titles of the NIH grants that were canceled. It is clear about the unscientific goals of this administration

🚨🆕🔬Three meals, same calories, different metabolism 🧬 Dörner et al show that our bodies shift from🔥carbs in the morning to fat by dinner- Glucose handling dips 📉 but metabolic resilience rises📈 w/ triglyceride use 👉 journals.physiology.org/doi/abs/10.1...
#Physiology #Science #Circadian #Metabolism

Cracking the Complexity of Long COVID: Akiko Iwasaki / Professor of Immunobiology, Yale University - Direct Talk | NHK WORLD-JAPAN Dr. Akiko Iwasaki has devoted her career to studying vaccines, to ward off infectious diseases. She talks about breakthroughs in understanding Long COVID, and the importance of diverse voices in scien...

NHK, Japan: 'Cracking the Complexity of Long COVID: Akiko Iwasaki / Professor of Immunobiology, Yale University'

'She talks about breakthroughs in understanding Long COVID, and the importance of diverse voices in science'

www3.nhk.or.jp/nhkworld/en/...

Trump officials will screen NIH funding opportunities Staff at biomedical agency worry about political interference in setting priorities

“DOGE and HHS will determine whether a particular NOFO can be published, even if it has already been approved by an NIH advisory council of independent scientists who normally review such programs…’How is that decreasing regulation/bureaucracy?’”

www.science.org/content/arti...

This recent #JournalClub by Federico Picciau @universitypost.bsky.social et al. examines the impact of exercise intensity on #neurogenesis and the work of Lambertus et al. (2024) 🧠 🏃

✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

📣 Did you hear the news? @apspublications.bsky.social reached our #SubscribeToOpen goals for 2025! Authors, find out how you can publish open access with APS #S2O journals.physiology.org/s2o-content-...