brian_delisle

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...

Excited to share a new story that transformed how we think about membrane domains in the ER!

rdcu.be/eR7Cn

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export

Wondering what’s so new and exciting? Skytorial below!

1/9

Effect of aspirin intake at bedtime versus on awakening on circadian rhythm of platelet reactivity. A randomised cross-over trial - PubMed The risk of acute cardiovascular events is highest during morning hours, and platelet activity peaks during morning hours. The effect of timing of aspirin intake on circadian rhythm and morning peak of platelet reactivity is not known. It was our objective to evaluate the effect of timing of aspirin …

This is outside my area but I found this interesting - as far as sex differences - it could be that one sex is more probe to certain CV disease more effectively treated by aspirin? pubmed.ncbi.nlm.nih.gov/25208590/

Graphs showing data of heart rate and core body temperature in control and diabetic mice.

🚨🆕🧪🔬 Congrats to @abhiprabhat.bsky.social - dim light at night exacerbates cardiac autonomic neuropathy (CAN) in diabetic mice & CAN disrupts coupling between heart rate and body temp 🫀⏱️
#CardiacAutonomics #Diabetes #Circadian #Physiology #CardioSky

www.heartrhythmjournal.com/action/showP...

Image of Mito matix pH with scale

🚨 🤯 new 🔬by @krishnanyamuna.bsky.social “… pH gradients exist within single, large or long organelles… ER..mitochondria..nucleolus..prompting
new questions about proton diffusion.. on organelle function.”
www.biorxiv.org/content/10.6...
Now I have update my Cell lectures for Spring- very 😎

Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

Review Article Long QT Syndrome Figure 1. ECG Patterns Suggestive of Long QT Syndrome.

A new review summarizes the genetics, diagnosis, and treatment of long QT syndrome, a major cause of sudden death in young people. Risk stratification and genotype-guided therapy are essential. Learn more in a new Review Article: nej.md/44cxXnN

#MedSky #CardioSky

🚨🆕🧪🔬 Hyperglycemia 👊🏻 the brain hard 🧠🔥 Miao, Mohiuddin et al shows GLUT1 is essential for brain endothelial cell survival under high glucose, w/o it, cells lose homeostasis and barrier function yikes😧
#Neurovascular #Diabetes #Physiology

journals.physiology.org/doi/full/10....

🚨🆕🧪🔬That “wild-type” Nav1.5 variant everyone’s been using may not be so WT after all. Melgari et al. reveal T559A causes loss-of-function ⚡️❌ decades of WT controls weren’t truly WT, time to double-check those studies🧐🧬
#IonChannel #Physiology #Reproducibility

journals.physiology.org/doi/full/10....

🚨🆕🧪🔬 Not all gut-brain signals follow the clock🕒🥣 Arnold and colleagues show CCK receptors + signaling in vagal afferents stay steady across day & night 🌞🌙 despite circadian rhythms 🧠➡️🍽️
#GutBrainAxis #Circadian #Physiology #Neuroscience

journals.physiology.org/doi/full/10....

If you are at #AHA25 go check out Dr. Prabhat’s @abhiprabhat.bsky.social poster- where he identifies feeding behavior as a potential modifiable risk factor for regulating autonomic input to the heart- It is TODAY 11:30am-12:30pm (Central) MC.APB.04

eppro02.ativ.me/web/index.ph...

#heart #CardioSky

Congrats to @kaesser.bsky.social @bpdelisle.bsky.social @abhiprabhat.bsky.social !!!

BMAL1 mediates sex-specific circadian regulation of cardiac ion channels and temporal arrhythmia vulnerability

🚨🆕🧪🔬on 💓🕒 Delisle et al. 😉show the circadian clock gene BMAL1 drives sex-specific daily patterns in cardiac ion channels ⚡️❤️‍🔥 in 🐭, shaping when arrhythmias may strike in males vs females 🧠➡️❤️
#Circadian #Physiology #Heart #Arrhythmia #Sex #Science #Cardiosky
www.sciencedirect.com/science/arti...

Thrilled to share our Creative Concepts paper published in Heart Rhythm on how the circadian clock gene Bmal1 mediates sex specific cardiac ion channel expression. authors.elsevier.com/a/1m1jJ5VtUy... @kaesser.bsky.social @bpdelisle.bsky.social @abhiprabhat.bsky.social

Yes, you can see the other submitted reviews after the due date.

Congrats!!!! You are doing amazing work - generating new knowledge!

Congratulations Abhilash- You are doing great research and doing so much hard work! Didn’t you just do a 2-day circadian collection earlier this week?

🚨 🆕 🔬 💥 Suzuki et al reveal Kir2.1 channels hyperpolarize macrophages, crank up CRAC channel–mediated Ca²⁺ entry ⚡and migration w/o touching phagocytosis or M2 polarization 🧫 It’s all about that K⁺ flow and CaMK–Pyk2 activation🧠🔥#Physiology #IonChannels
👉 journals.physiology.org/doi/full/10....

Asprosin attenuates diabetic cardiomyopathy through inhibiting autophagy mediated by AMPK/mTOR/ULK1 pathway | American Journal of Physiology-Cell Physiology | American Physiological Society Aberrant autophagy mediated by AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/unc-51 like kinase 1 (ULK1) pathway (a canonical autophagy pathway) plays important roles in dia...

🚨 🆕 🫀🔬🔥 Wang et al: Asprosin 💥 protects the diabetic heart by dialing down overactive autophagy via the AMPK/mTOR/ULK1 pathway 🧬 No Asprosin = more fibrosis & more apoptosis 😱 💉🧠 #CardioSky #Physiology #autophagy
👉 journals.physiology.org/doi/full/10....

🚨 🆕 🔬 Pereira Jr. et al. show that MitoKATP channels are vital for brown adipocyte 🔥 growth—but are switched off for thermogenic blast 💥 in mature cells. Cold? NE? Block the channel, burn the fuel. ❄️🧬 👉 journals.physiology.org/doi/abs/10.1...
#IonChannels #Physiology

🚨 🆕 🔬 Melgari et al show widely used “WT”cardiac🫀Na+ channel (SCN5A, Nav1.5) clone carries the rare T559A variant 🧬. T559A shows loss-of-function, halved Na+ current, & altered kinetics 🧪 👉 journals.physiology.org/doi/abs/10.1...
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky

🚨 New 💪 🔬 Naughton et al. reveal NOMO as a force-bearing ER protein that shapes ER structure & drives muscle cell fate—Its Ig-domain handles piconewton-scale tension, delete it, and myogenesis breaks down 🧬
🔧👉 rupress.org/jcb/article/...
#Physiology #Cell #Science #Muscle

Bhlhe40 (a known negative regulator of BMAL/CLOCK activity) as a transcriptional activator of SMC-to-foam cell transition in #Atherosclerosis

Ldlr-/- Myh11-CreERT2 ROSA26-ZsGreen1🐭
CITE-seq (119 Ab)

Only 1~3% (Not 30%!) Mφ-like cells are SMC-derived 🤓

bioRxiv 2025
www.biorxiv.org/content/10.1...

Cross-Talk of Cells in the Heart 2025: Novel Mechanisms of Disease and Arrhythmias Cross-Talk of Cells in the Heart 2025, an exciting two-day meeting at University of Birmingham (UK) to discuss the latest breakthroughs in cardiac arrhythmia and disease research. Join us

📢 Final call! Submit your abstracts to present your research at our meeting, ‘Cross-Talk of Cells in the Heart 2025’ at the University of Birmingham on 3-4 Sept. Showcase your findings on the mechanisms of heart disease and arrhythmias.

📝 Submit by 2 June ⬇️

Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia Ducharme et al. investigate the impact and crosstalk between cancer and FoxP1 on the skeletal-muscle circadian transcriptome that mediates time-of-day-dependent biological functions. They reveal cance...

Its taken a few years but finally had science fun collaborating with @andyjudge24.bsky.social, @sarahjudge.bsky.social and the talented postdoc @jbducharme.bsky.social with support from Miguel Gutierrez-Monreal. Cancer and the muscle clock. 1/ www.cell.com/cell-reports...

Graphical abstract - cell mechanics, histology and western blots.

Excited to see (newly Dr) Greg Milburn's paper on cardiac amyloidosis in human myocardium with cell-level mechanics, histology, and gel-based analysis of sarcomeric proteins.

Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis
doi.org/10.1016/j.ja...

We are very pleased to share that our paper on sexual dimorphism in circadian rhythms has been published in @plosbiology.org. This work was led by the very talented Aishwarya Iyer and includes contributions from three undergraduate co-authors.

You can read the full study here:

For the last 3 yrs, I was the director for the Science of Science program at the NSF. We funded projects on science communication - science communication to the public, communication of public priorities to scientists, citizens engagement & participation in science. 🧵

Please read this.

GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15

#FreeToRead 👀

CONGRATULATIONS!

An ovary-intact #postmenopausal #HFpEF mouse model; #menopause is more than just #estrogen deficiency
Mei Methawasin, et al.

➡️doi.org/10.1152/ajph...