Julien Ochala's Avatar

Julien Ochala

@droch.bsky.social

Associate Professor at the University of Copenhagen - https://bmi.ku.dk/english/research/exercise-and-muscle/ochala-group/

593 Followers  |  550 Following  |  95 Posts  |  Joined: 02.02.2024  |  1.7899

Latest posts by droch.bsky.social on Bluesky

Our new project unveiling an integrative single-fiber framework that connect multi-omic cellular heterogeneity to molecular function in ICU-related muscle wasting! Congratulations to all authors especially Alexandra who led the whole project! Thank you to @lundbeckfonden.bsky.social for the support

17.02.2026 15:54 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Very interesting study unravelling cardiac myofibrillar plasticity in the animal kingdom! Huge effort from colleagues at CU Boulder (with very humble contribution from our lab)

10.02.2026 08:35 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Postdoc in cardiac sarcomere biology at Department of Biomedical Sciences Postdoc in cardiac sarcomere biology at Department of Biomedical Sciences  Faculty of Health and Medical Sciences University of Copenhagen We are looking f

Postdoc opportunity in our group in sunny Copenhagen β˜€οΈ candidate.hr-manager.net/ApplicationI...

29.01.2026 15:05 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Destabilization of cardiac myosin acetylation and sequestration with type 2 diabetes mellitus - Cardiovascular Diabetology Background Type 2 diabetes mellitus (T2DM) predisposes patients to adverse cardiac remodeling even before the development of cardiomyopathic symptoms. The mechanisms for such early perturbations remai...

Our latest collaborative work highlighting an early cardiac myosin dysfunction in diabetic patients (even without any cardiomyopathy)! @ucph.bsky.social funded by @novo-nordisk.bsky.social

16.01.2026 13:56 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer - Nature Metabolism Multi-omics profiling of diverse cancer cachexia models uncovers a multi-tissue metabolite-coordinated response associated with disease progression and links multi-tissue one-carbon metabolism to wast...

Impressive study!

15.01.2026 14:57 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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When to target the most abundant protein in the heart?

@droch.bsky.social & team show myosin becomes maladaptive in X-linked myotubular myopathy, consuming excessive energy, and inhibiting its ATPase activity in mice partly rescues the molecular defects: doi.org/10.1172/jci....

24.12.2025 14:01 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Ochala Group – University of Copenhagen

Our team at KΓΈbenhavns Universitet - University of Copenhagen will soon be looking for a postdoc with experience in AI-driven vHTS and cardiac sarcomere modeling. If interested please send me an email. Spread the word :-)

18.12.2025 11:29 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Assaying the myosin super-relaxed state across muscle types, cells and proteins for understanding muscle biology and use in drug discovery - Nature Protocols The Mant-ATP assay is a simple and accessible means for rapid quantitative assessment of the ratio of super-relaxed myosin to disordered relaxed myosin. This protocol provides a standardized methodolo...

Great collaborative work led by Christopher Toepfer and his team at the University of Oxford

01.12.2025 16:21 β€” πŸ‘ 10    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
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Reader in/Professor of Immunobiology | King's College London

We are recruiting a Reader/Professor of Immunobiology at @kingslsm.bsky.social . This is a unique opportunity to shape basic immunology at @kingscollegelondon.bsky.social . Please RP.
www.kcl.ac.uk/jobs/131447-...

24.11.2025 12:29 β€” πŸ‘ 5    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Top selling from pharma companies

23.11.2025 07:48 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Cardiac Chamber‐Specific Regulation of Myosin Biochemical Super‐Relaxation and Auto‐Inhibition The combination of Mant-ATP (2β€²-(or-3β€²)-O-(N-Methylanthraniloyl) Adenosine 5β€²-Triphosphate) chase experiments and all-atomistic molecular dynamics simulations, revealed that myosin auto-inhibition an...

Our collaborative effort unravelled puzzling results warranted more research on the topic of myosin and cardiac chamber specificities @ucph.bsky.social

22.11.2025 12:57 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
JCI Insight - Myosin inhibition partially rescues the myofibre proteome in X-linked myotubular myopathy

Excited to present our recent work on myosin as a molecular target for genetic muscle diseases! Kudos to all authors, especially Elise, Fanny and @myofinlab.bsky.social @ucph.bsky.social

13.11.2025 10:18 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Asterix and/et Ozempix

12.11.2025 08:00 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Recruiting a comp PDRA for the lab 🚨

Working on multiple projects using integrated multi omics in bulk & single cell level

Passion for data, coding, bioinformatics & keen to lead our labs comp workflow

12 months in first instance but extendable for further 19 months

my.corehr.com/pls/coreport...

10.11.2025 17:23 β€” πŸ‘ 4    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

Multilingualism protects against accelerated aging www.nature.com/articles/s43...

10.11.2025 17:24 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle

Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!

29.10.2025 07:59 β€” πŸ‘ 6    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0

We are grateful to Independent Research Fund Denmark for funding our new project aiming to understand and treat heart failure! The project will take place at @ucph.bsky.social

23.10.2025 15:48 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Congratulations Glenn and team πŸ‘

16.10.2025 08:55 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Congratulations! Impressive work!

05.10.2025 15:18 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Very nice πŸ‘πŸ‘

05.10.2025 12:08 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

πŸ‘ very important paper

03.10.2025 15:45 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Ensure #ISHLT2026 will be next level. ▢️ Submit your science in the treatment of advanced #heart and #lung disease, #transplantation, #MCS, and #PVD by πŸ“† 14 October: πŸ”— https://bit.ly/4dLYGdn

30.09.2025 20:39 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme

We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere

29.09.2025 11:11 β€” πŸ‘ 4    πŸ” 4    πŸ’¬ 0    πŸ“Œ 1

The Danish system NEM ID is actually working and very efficient! However DK is far smaller than UK…

27.09.2025 09:01 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Fully agreed- diversity is key

26.09.2025 14:53 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London

🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important

Good collab with @droch.bsky.social so travel to CPH involved as well

www.kcl.ac.uk/jobs/126245-...

25.09.2025 17:01 β€” πŸ‘ 6    πŸ” 8    πŸ’¬ 0    πŸ“Œ 1

Drugs targeting muscle mass seem to be trendy at the minute (but a lot of them are unfortunately left along the way)

25.09.2025 16:17 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Eli Lilly halts trial testing experimental muscle-preserving drug with Zepbound Eli Lilly has halted a study of an experimental drug, designed to prevent obesity patients from losing too much muscle, due to strategic business reasons, according to a U.S. registry of clinical trials.

This trial has been stopped for strategic business reasons

25.09.2025 16:01 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London

Postdoc opportunity in muscle cell biology! You would not only be involved in an ambitious project but would also help develop cutting edge methods! Highly recommended! @robertseaborne.bsky.social

25.09.2025 15:31 β€” πŸ‘ 6    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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UAB and Children's of AL is looking for a new Division Director of Pediatric Neurology (come be one of my bosses!). We are consistently in the top 30 nationwide in Pediatric Neurology and have excellent subspecialties in: Epilepsy, Autism, and NMDs. Apply: tinyurl.com/y8d8duve

04.09.2025 15:57 β€” πŸ‘ 2    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

@droch is following 20 prominent accounts