Massimiliano Stagi

In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.

An #NIH-funded research team has developed an mRNA vaccine to treat pancreatic cancer. Results from the clinical trial were published this week in Nature.

#pancreas #cancer #mRNA #vaccine #medsky #science #medicine #bluesky

Time for some mito-business. Or should we say methyl-business?? Let's ask our speaker Thomas MacVicar.
This thursday, usual time and place.

RpH-ILV: Probe for lysosomal pH and acute LLOMe-induced membrane permeabilization in cell lines and Drosophila The ratiometric lysosomal probe RpH-ILV enables improved pH tracking and reveals lysosomal dynamics and susceptibility to damage.

Our new study: www.science.org/doi/10.1126/.... It provides useful tools for studying LLOME lysosomal damage.

An important and beautiful structure of the native dystrophin glycoprotein complex!.

‘Dark proteome’ survey reveals thousands of new human genes Database confirms that overlooked segments of the genome code for a multitude of tiny proteins

‘Dark proteome’ survey reveals thousands of new human genes | Science www.science.org/content/arti...

MITOtalks have not made it here (yet) but we are excited to host two fantastic trainee talks this week on MITOchats - Alia Edington from Friedman lab at UTSW and David Eberhardt from Chaudhuri at UUtah - visit www.mitotalks.org for more info and zoom link to join! #mitochondria please share!

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...

Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.

www.science.org/doi/10.1126/...

Beautiful imaging on the cover but also check out the beautiful imaging inside and our story on #endosomes and #GTPase cascades

We’re hiring tenure-track faculty focused on Systems & #ComputationalNeuroscience at the Friedman Brain Institute at Mount Sinai!

We're starting to review applications so submit yours ASAP! 👇

DeepMind Releases AlphaFold 3 Code and Weights -- MedCloudInsider In a move that surprised the scientific community, DeepMind, a division of Google parent company Alphabet focused on developing general-purpose artificial intelligence technology, has released the sou...

In a move that surprised the scientific community, DeepMind released the source code and model weights for AlphaFold 3, its groundbreaking AI system for predicting molecular interactions.
medcloudinsider.com/Articles/202...

#ai #healthcaretech #medicaltech

Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳

Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of microbial extracellular vesicles https://www.biorxiv.org/content/10.1101/2024.11.18.624161v1 The efficient recognition and removal of apoptotic cells by phagocytes is critical to prevent second

Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of microbial extracellular vesicles https://www.biorxiv.org/content/10.1101/2024.11.18.624161v1

Impact of #Ageing and Disuse on #Neuromuscular Junction and #Mitochondrial Function and Morphology: Current Evidence and Controversies
www.sciencedirect.com/science/arti...

Fueling neurodegeneration: metabolic insights into microglia functions
jneuroinflammation.biomedcentral.com/articles/10....

Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

Evidence for heterogeneity in endosomal-origin organelles and their positions from @melikel.bsky.social

No significant differences in the distance of the subpopulations from the nucleus. NPC1-positive late endosomes/lysosomes can be closely positioned to mitochondria

doi.org/10.1083/jcb....

Hello, world! Looking forward to connecting with new and old friends.

Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/
G. Napolitano,A. Esposito, and A. Ballabio.

This #fluorescencefriday I am gonna introduce some work from the lab :) We identified a new GTPase cascades that we believe drives cargo flow along post-Golgi pathways! Compartments positive for ARF1 shed ARF1 (green) to acquire Rab11 (magenta) to become recycling endosomes. Can you spot an event?