Melanie Mittenbühler

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

📢 Publication Alert: We're excited to share a new study from the Langer Lab published in @nature.com! It uncovers how an excess of RNA building blocks can destabilize mitochondrial DNA, which plays a role in age-related inflammation.

www.nature.com/articles/s41...

We are hiring 🔍📢

Are you curious about how exercise promotes positive changes at the molecular level in obesity and diabetes? Then apply as a Postdoctoral Researcher in Dr. Melanie Mittenbühlers team.

Read more: ddz.de/job/postdoct...

@mellimittenblr.bsky.social

Postdoctoral Researcher (Ph.D./Dr. rer. nat., m/f/div., E13 TV-L, 100%) - Deutsches Diabetes-Zentrum (DDZ) Institut für Klinische Biochemie und Pathobiochemie (Direktor: Univ.-Prof. Dr. rer. nat. Hadi Al-Hasani), Nachwuchsforschungsgruppe Crosstalk (Leiterin: Melanie Mittenbühler, Dr.) (25019)

‼️ We're looking for a postdoc to join our team starting January 1st, 2026! ‼️
Are you curious about how exercise promotes positive changes at the molecular level in obesity and diabetes? If so, consider applying or reach out with any questions.

ddz.de/job/postdoct...

ddz.de/en/research/...

An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution to...

Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉

🧫 New galactose #CRISPR screen
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂 Mito defects in #Menieres

www.cell.com/cell-reports...

Geruch von Essen kann Sättigung auslösen – neue Erkenntnisse Essverhalten: Schon der Geruch von Essen kann das Sättigungsgefühl auslösen – zeigen Forschende am Max-Planck-Institut. Bei Übergewicht scheint dieser Mechanismus gestört zu sein.

Ever wondered how smell affects how you eat? 👃🍽️
Check out this interview (in German) with my fantastic PhD student @janice-bulk.bsky.social on our latest paper! 🧠📄
#ProudPI #Olfaction #Satiety #Neuroscience

👇 www.swr.de/leben/gesund...

#OpenAccess: Review from Physiological Reviews, Biomarkers of #aging: from molecules and surrogates to physiology and function

Regula Furrer and Christoph Handschin
🖱️doi.org/10.1152/phys...
#exercise #healthspan #longevity @unibas.ch‬

Big congrats Sophie and team 🥳

The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT Nature Communications - Thermogenesis by brown adipose tissue has long been thought to be solely controlled by uncoupling protein 1 (UCP1). Here, the authors show that energy expenditure in brown...

Today in @naturecomms.bsky.social we show the #FutileCreatineCycle plays a key role in #thermogenesis, independent of UCP1. We also challenge the belief that brown adipocytes lack enough ATP synthase for thermogenesis. Congrats to Jakub Bunk! @mcgillgci.bsky.social

Full paper: rdcu.be/egoV7

Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling Short-term transition to high-fat diet (HFD) feeding causes rapid changes in the molecular architecture of the blood-brain barrier (BBB), BBB permeabi…

Congratulations, Yiyi! 🎉
We find that high-fat diet rapidly reduces Notch signaling in the brain, affecting glucose uptake and insulin sensitivity. Our study also highlights the role of caveolae in blood-brain barrier permeability and insulin transport:
www.sciencedirect.com/science/arti...

An open letter to graduate students and other procrastinators: it’s time to write - Nature Biotechnology Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write

A beautiful article about writing, which also advocates against the use of LLM when learning academic writing

www.nature.com/articles/s41...

RBM43 controls PGC1α translation and a PGC1α-STING signaling axis Dumesic et al. identify RBM43 as an RNA-binding protein that governs mitochondrial biogenesis through suppression of PGC1α translation. RBM43 is induced by inflammatory signaling and controls a diabetogenic regulatory axis in adipocytes whereby decreased…

Online now: RBM43 controls PGC1α translation and a PGC1α-STING signaling axis

Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST Sprenger et al. used a systematic approach to identify how mitochondria remodel their metabolome in response to exercise. The diet-derived, atypical amino acid ergothioneine (EGT) accumulates in muscle mitochondria with exercise training. EGT binds to and…

Online now: Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST

Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST Sprenger et al. used a systematic approach to identify how mitochondria remodel their metabolome in response to exercise. The diet-derived, atypical amino acid ergothioneine (EGT) accumulates in muscl...

A combination of #exercise physiology, molecular biology & biochemistry studies identifies the Ergothioneine-3-mercaptopyruvate sulfurtransferase axis as a molecular mechanism for regulating mitochondrial function and #exercise performance @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...

Our paper showing that ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST is now published @cp-cellmetabolism.bsky.social

Thanks to everyone involved!

www.cell.com/cell-metabol...

Doctoral Student (PhD/Dr. rer. nat., m/f/div., E13 TV-L 65%) - Deutsches Diabetes-Zentrum (DDZ) A job-opening of the German Diabetes-Center (DDZ). (24681)

Very happy to share that my research group has launched at the German Diabetes Center (DDZ) in Düsseldorf!

We're looking for a PhD student to study the effects of inter-tissue communication on energy balance and metabolic health. Interested? Get in touch!

ddz.de/en/job/docto...

With two complete starter packs (in my profile), here is a 3rd one for the ever-growing metabolism community. Please contact me if you are working (prerequisite) on metabolism and want to be included here; there is still some space. I will keep updating it.

go.bsky.app/7Uwa6fb

Very excited to start 2025 sharing our latest work @ppuigserverb.bsky.social published in @naturecellbiology.bsky.social! We have shown that the cytosolic chaperone PPID/CYP40 inserts TOM70, connecting chaperones and mitochondrial protein biogenesis to the development of chronic metabolic disorders

big congrats!

The human zinc-binding cysteine proteome A deep mapping of the human zinc-binding cysteine proteome (ZnCPT) defines thousands of zinc-binding protein cysteines across major domains of biology and discovers glutathione reductase as zinc-targetable cancer vulnerability.

Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...

One of the biggest questions we get is when will our journals be here. We thank you for your patience.

You can now follow our journals with this starter pack!

📢We're recruiting📢

Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!

Please share

#uridine #cancermetabolism #immunometabolism

@unil.bsky.social

🔗(PDF): www.jourdainlab.org/wp-content/u...

11/ Bruna Martins Garcia thought a good PhD student had to be fully independent until writing in a new language began hindering her opportunities.

She told #SparksOfChange how she took the leap and started her own writing club, and how you can do the same!
https://buff.ly/3CWk823

I'm thrilled to co-organize the inaugural #AdiposeBiology conference with Jacqueline Beaudry, Hoon-Ki Sung, and @sablesys.bsky.social!

📍Montreal, Canada
📅 August 19-20, 2025

Registration opens Jan 1, 2025. Mor info in the coming weeks.

Hope to see you there! @AdiposeBiology #AdiposeBiology2025

I have curated a second "metabolism" starter pack, as the first quickly got full. Please have a look, and I am happy to add others (sorry for those who may appear in both): go.bsky.app/CH1MctZ

Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025

Could you live without glutamine?

I am delighted to share our preprint @jourdainlab.bsky.social: we employed parallel nutrient and genetic screening to tackle the mechanisms promoting survival in glutamine-limiting conditions. Check it out 👇 more details below!

www.biorxiv.org/content/10.1...

Structural basis of respiratory complex adaptation to cold temperatures High-resolution structures of respiratory I:III2 complexes from brown fat adapted to cold temperatures reveal a distinct supercomplex assembly with rotated CIII2 that displays higher electron transfer...

In the latest issue of Cell- Structural basis of respiratory complex adaptation to cold temperatures

Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues Communication between tissues or different cells within a tissue is often a result of secreted molecules such as metabolites, lipids, nucleic acids, o…

Need a detailed protocol for isolating and preparing extracellular fluids for proteomics? Find our step by step protocol here:

www.sciencedirect.com/science/arti...

@amandalsmythers.bsky.social