This is such a great idea! Thank you for making this. Could you please add me?✋
Thank you
Is there still space?
6/ Many thanks to Chen and Tom for inviting us to collaborate and expand on our shared interest in how Opa1 perturbations drive changes in mitochondrial ultrastructure.
5/ Our findings bring us closer to understanding the molecular mechanisms behind ADOA and open new avenues for developing targeted therapies to prevent neurodegeneration.
4/ We've identified Sarm1 as a key driver of RGC degeneration in our mouse model. Remarkably, knocking out SARM1 nearly completely suppresses these degeneration phenotypes, offering new hope for potential therapies.
3/ Using cryo-ET, we quantified architectural changes in mitochondrial ultrastructure, giving us detailed insights into how this pathogenic OPA1 mutation affect mitochondrial integrity at the nanoscale level.
2/ Our novel mouse model carrying the Opa1R290Q/+ allele recapitulates key features of human ADOA, including mitochondrial defects, age-related RGC loss, optic nerve degeneration, and reduced RGC function.
1/ ADOA, a common inherited optic neuropathy, leads to RGC degeneration and vision loss. It's primarily caused by mutations in the OPA1 gene, a key player in mitochondrial inner membrane dynamics.
Excited to share our collaborative work characterizing a pathogenic mutation in Opa1 found in ADOA patients that began when Tom Schwarz
@BostonChildrens
presented a seminar
@MGHMolBio
biorxiv.org/content/10.1...
@lukechao.bsky.social
4/ We've identified Sarm1 as a key driver of RGC degeneration in our mouse model. Remarkably, knocking out SARM1 nearly completely suppresses these degeneration phenotypes, offering new hope for potential therapies.
3/ Using cryo-ET, we quantified architectural changes in mitochondrial ultrastructure, giving us detailed insights into how this pathogenic OPA1 mutation affect mitochondrial integrity at the nanoscale level.
2/ Our novel mouse model carrying the Opa1R290Q/+ allele recapitulates key features of human ADOA, including mitochondrial defects, age-related RGC loss, optic nerve degeneration, and reduced RGC function.
1/ ADOA, a common inherited optic neuropathy, leads to RGC degeneration and vision loss. It's primarily caused by mutations in the OPA1 gene, a key player in mitochondrial inner membrane dynamics.
