Michael Schrift

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We neurologists fall in love with our hypotheses: they never die. The latest: Depending on where Lewy pathology is first found, one of 2 #Parkinsons types exists. @ajlees and I explain the newest inconsistency in this “brain-first/body-first” hypothesis.
journals.sagepub.com/doi/10.1177/...

Recruiting for our UCNS-accredited Behavioral Neurology/Neuropsychiatry Fellowship Training Program for Psychiatrists and Neurologists at the University of Washington in Seattle.

neurology.uw.edu/education/fe...

depts.washington.edu/mbwc/about/b...
If interested, email mschrift@uw.edu

Language and the Cerebellum: Structural Connectivity to the Eloquent Brain Abstract. Neurobiological models of receptive language have focused on the left-hemisphere perisylvian cortex with the assumption that the cerebellum supports peri-linguistic cognitive processes such ...

@kjobson.bsky.social just won honorable mention as paper of the year from the Neurobiology of Language for our (really her) cerebellar paper.with @ingridsbrain.bsky.social and me. direct.mit.edu/nol/article/...

NEW: Gavin Newsom announces a "HISTORIC" event this Thursday

Recruiting for our UCNS-accredited Behavioral Neurology/Neuropsychiatry Fellowship Training Program for Psychiatrists and Neurologists at the University of Washington in Seattle.

neurology.uw.edu/education/fe...

depts.washington.edu/mbwc/about/b...
If interested, email mschrift@uw.edu

Is there going to be a credibility hit to every "centrist" and right-wing alternative media pundit who told us that tariffs were just going to be a negotiation tactic?

YouTube video by Kathleen Vancleef Assessment of object agnosias

We're back again with a new video on assessing visual perception difficulties. This time we focus on object agnosias. How to easily tell apart associative, apperceptive agnosia and optic aphasia. 🧑‍🎓🩺🧠

Find out: youtu.be/1W4F7Wp0qcA

The eventual fate of the GOP

Editor's Choice | Catatonia

The ANPA catatonia SIG (including @asynaptic53.bsky.social and I) did this review about catatonia articles in JNCN.

Welcome to the United States of Kakistan

Important to stay even-keeled, and I'm trying.He already has made some significant blunders, esp birthright citizenship. But it's the Tarrio commutation, if true,that makes you want to puke. I cannot think of a remotely similar betrayal of country by a sitting President. @hcrichardson.bsky.social ?

Trump’s legal arguments for postponing or canceling today’s sentencing by Judge Merchan were so patently ridiculous that the four Justices who signed onto them by dissenting yesterday have erased any residual doubt that they’re willing to swallow whatever crap Trump’s lawyers will throw his way.

Remarkable that GOPers get away with this crap. They worship a convicted felon who incited a riot in which 140 cops were beaten and injured and who has vowed to pardon the cop-beaters.

Jeff Bezos never wanted this cartoon to become public.

He killed it, and as a result, pulitzer prize editorial cartoonist Ann Telnaes quit.

Make sure everyone sees this cartoon.

Clinical use of biomarkers in the era of Alzheimer's disease treatments With the advent of treatments that specifically target Alzheimer's disease brain pathology, biomarker tests will become an increasingly important part of the routine clinical evaluation of cognitive ....

This article discusses clinical use of biomarker tests for Alzheimer's disease pathology, including indications for testing, review of biomarker modalities (PET, CSF, blood), selection of modality based on individual factors, and interpretation and return of results. #ENDALZ
doi.org/10.1002/alz....

Highly recommend!

Happy Birthday Dr.Fauci and thank you for saving us! 💙

Beautiful capture…..Mount Rainier National Park 🇺🇲

Donald Trump tapped drug user Matt Gaetz, who was found by the House Ethics Committee to have had sex with a 17-year-old girl, as America's Attorney General. The country's top cop! If you're not outraged by such blatant hypocrisy, you're not paying attention.

The children were sleeping all tucked in their beds, while visions of DERANGED JACK SMITH SWAMP WITCH HUNT (unprecedented!) danced in their heads

Donald Trump’s excellent first choice for Attorney General of the United States.

Matt Gaetz ethics report says he paid 17-year-old for sex, used drugs while in Congress

www.msnbc.com/top-stories/...

Every single MAGA politician knew exactly who Matt Gaetz is and they were cheering him on to be our attorney general.

Let that sink in.

New insights into Alzheimer's disease biomarkers How are emerging plasma biomarkers related to the diagnostic tests currently used in clinical routines? And does the earlier evidence from highly selective research cohorts translate to the heterogene...

The study found that all tested plasma #biomarkers (except for NfL) were associated with accumulation of misfolded amyloid in the brain, highlighting the role of amyloid in the phosphorylation of tau.

#Alzheimers #dementia #neuroscience #neuroskyence

Roche’s Phase IIb study of prasinezumab missed primary endpoint, but suggests possible benefit in early-stage Parkinson’s disease PADOVA study showed numerical delay in motor progression and positive trends on multiple secondary and exploratory endpointsPrasinezumab continues to be well tolerated and no new safety signals were.....

Trials should test hypotheses, not confirm biases. But the negative prasinezumab results won't end anti-synuclein pursuits; the idea of synuclein as "good turned evil" in Parkinson's is deeply rooted. We won't let any trial derail our beliefs.
www.roche.com/media/releas...

I'm going to post this video every day so we never forget

I think this should be kind of a big deal: Elon Musk tweeting at 1:03am, “Only the AfD can save Germany.”

The AfD is Germany’s neo-Nazi party.