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David Lynn

@davidjlynn.bsky.social

Professor and Group Leader at SAHMRI and Flinders University. Scientific Director SA Genomics Centre. Research interests in systems immunology; host-microbe interactions; genomics, cancer systems biology.

61 Followers  |  95 Following  |  6 Posts  |  Joined: 02.04.2025  |  1.8899

Latest posts by davidjlynn.bsky.social on Bluesky

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Early Life Antibiotics Put Vaccine Response at Risk While antibiotics given in the first week of life reduce vaccine responses at 15 months, probiotics might counteract these effects.

www.the-scientist.com/early-life-a...

28.04.2025 23:39 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Thanks @natrevimmunol.bsky.social for highlighting our recent @nature.com paper! @flindersuniversity.bsky.social @sahmri.bsky.social

25.04.2025 02:45 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Based on these findings we will soon start a randomised controlled trial to determine if a probiotic intervention can boost vaccine responses in infants that received antibiotics in the neonatal period. Funded by
@WCHFoundation

02.04.2025 23:52 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Very grateful to all our collaborators especially @HelenSMarshall and her team, the infants and their parents who participated in our study, our facilities incl @SA_genomics and the @sahmri.bsky.social
germ-free and flow facilities and our funders @nhmrc.bsky.social and the WCH Foundation

02.04.2025 23:52 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Neonates who received antibiotics had significantly lower antibody titres to multiple different vaccine antigens especially polysaccharides in the PCV13 vaccine.

02.04.2025 23:52 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Our paper out today in @nature.com shows the important role Bifidobacteria in the infant gut microbiota play in mediating optimal responses to vaccination.

02.04.2025 23:52 β€” πŸ‘ 10    πŸ” 3    πŸ’¬ 1    πŸ“Œ 1

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