Do you know what happens when you touch a carnivorous sundew plant?
If the touch is strong and large enough, a cytosolic calcium wave will spread from the site of touch throughout the whole plant, but if you only touch one tentacle (see post below), the calcium wave will be local and less intense.

In vivo single-cell gene editing using RNA electroporation reveals sequential adaptation of cortical neurons to excitatory-inhibitory imbalance https://www.biorxiv.org/content/10.1101/2025.09.13.672380v1

Thank you Mathias! Your view as the founder of the European Stress meeting and a thought leader in the field just made my week! 🧪🧠 #Stressneurobiolgy

I fell in love with neurophysiology because of the beautiful biophysical properties of stellate cells
pubmed.ncbi.nlm.nih.gov/8395571/

Finally I go back to these cells and put biocytin in them and what a wonderful surprise
Stained and imaged by Kristian Moan @gquattrocolo.bsky.social
#neuroskyence

Confocal microscopy photo

Astrocytes🔵 reacting to B-amyloid🟣 accumulation in the Human Neocortex. One of the hallmarks of #Alzheimers and other neurodegenerative conditions. What if viral infections increase the accumulation of these and other misfolded proteins in the brain? 🤔🔬 #FluorescenceFriday

A Guide to Misinformation Detection Data and Evaluation
https://arxiv.org/abs/2411.05060

Astrocyte-secreted cues promote neural maturation and augment activity in human forebrain organoids | Nature Communications Brain organoids have been proposed as suitable human brain model candidates for a variety of applications. However, the lack of appropriate maturation limits the transferability of such functional tools. Here, we present a method to facilitate neuronal maturation by integrating astrocyte-secreted factors into hPSC-derived 2D and 3D neural culture systems. We demonstrate that protein- and nutrient-enriched astrocyte-conditioned medium (ACM) accelerates neuronal differentiation with enlarged neuronal layer and the overproduction of deep-layer cortical neurons. We captured the elevated changes in the functional activity of neuronal networks within ACM-treated organoids using comprehensive electrophysiological recordings. Furthermore, astrocyte-secreted cues can induce lipid droplet accumulation in neural cultures, offering protective effects in neural differentiation to withstand cellular stress. Together, these data indicate the potential of astrocyte secretions to promote neural maturat

Astrocyte cues boost neuron maturity in forebrain organoids, thanks to protein and nutrient-rich medium. From 2D to 3D cultures, neurons mature faster! PMID:40122897, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-58295-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Astrocytes in the mouse brain respond bilaterally to unilateral retinal neurodegeneration | PNAS Glaucomatous optic neuropathy, or glaucoma, is the world’s primary cause of irreversible blindness. Glaucoma is comorbid with other neurodegenerati...

www.pnas.org/doi/abs/10.1...

ASiDentify (ASiD): A Machine Learning Model to Predict New Autism Spectrum Disorder Risk Genes Abstract. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects nearly 3% of children and has a strong genetic component. While hund

academic.oup.com/genetics/adv...

Hello, everyone! Please enjoy one of my favorite micrographs while I finally get set up over here. Vasculature (magenta, perfused lectin), GFAP (cyan), and cx43 (green) in a conditional astrocyte cx43 knockout mouse, demonstrating that cx43 is lost from astrocytes but not pericytes after tamoxifen.

I wrote a recent survey about deep reinforcement learning. The paper is a compact guide to understand some of the key concepts in reinforcement learning.

Link: arxiv.org/pdf/2401.023...

#ReinforcementLearning #ICLR2025 #ACL2025 #NAACL2025 #NeurIPS2024 #ICML2025 #DeepRL #DeepReinforcementLearning

Hello! I'm a neuroscientist working on astrocytes and brain states! Happy to be here and interested to see what it's like. Here's a video of astrocyte and neuron activity we recorded to start things off. #introduction #neuroscience #datascience #astrocytes

I might as well post my favorite animation I've made here. This is an EM reconstructed astrocyte surrounding a single neuron in mouse visual cortex. Meshes from the MICrONS dataset. #neuroscience #astrocytes

Not only was that the conservative line in Canada the police caught a conservative voter starting wildfires who as I remember was trying to create a narrative that climate activists were starting fires to get people worried

I see the bots have made it to bluesky with some of the comments in here

A single-cell mass cytometry-based atlas of the developing mouse brain - Nature Neuroscience In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a protein-based single-cell profiling ...

I am usually not fan of atlases… but this one is actually useful, as it demonstrates the value of protein-level measurements to identify functional cell states. #Brain #Development www.nature.com/articles/s41...

Spatial organization of astrocyte clones: The role of developmental progenitor timing Astroglial clones vary in distribution, within or across cortical layers. Distribution of clones depends on their origin. Layer-specific clones have fewer, less dispersed cells. Juxtavascular clones...

onlinelibrary.wiley.com/doi/10.1002/...

Astroglial Hmgb1 in postnatal #Astrocyte morphogenesis & #NeuroGlioVascularUnit maturation
#SciArt

Aldh1l1-CreERT2:Hmgb1 f/f🐭➡️
⏬Astroglial endfeet coverage over vessels
⏬Single-cell #BranchingMorphogenesis

@blacoste.bsky.social @naturecomms.bsky.social 2023
www.nature.com/articles/s41...

Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance Transient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of…

Our paper on ketamine’s effect on astrocytes and behavior is out in Neuron by Marc Duque, Alex Chen, Eric Hsu, and colleagues @marcduque.bsky.social @alexbchen.bsky.social @ehsu6.bsky.social, with the Engert, Fishman, & Bergles labs, www.sciencedirect.com/science/arti...

Happy #FluorescenceFriday !🔬🤩
Here’s a close-up of a reactive astrocyte in a mouse cortex (featured at the Zeiss microscopy booth at SFN 2024!) — 🔴GFAP, 🟢C3, and 🔵DAPI

Happy post-Thanksgiving #FluorescenceFriday — here’s some recent images of the glial scar border that forms in mice after stroke 🌟🔬

🟢GFAP, 🟣SOX9, 🔵DAPI

Let's unleash the axonal growth cones for this #Fluorescencefriday ! #neuroscience #Liveimaging #microscopy #Axonguidance

congratulations to @pryprk.bsky.social for her recent review article in #GLIA on the role of lipids in microglial function.

onlinelibrary.wiley.com/doi/full/10....

Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages Extrasinusoidal dural macrophages are a distinct subset of immunologically active central nervous system–associated macrophages.

This week in #Science #Immunology: Lukas Amann, Marco Prinz, & colleagues at @uni-freiburg.de report that #extrasinusoidal #macrophages in the #mouse #DuraMater represent a distinct subset of #CNS -associated macrophages whose role is shaped by #autoimmune #neuroinflammation! #neuroimmunology

Image of preprint author line and title from bioRxiv

In our recent preprint, we unveil a new role for neural activity in the human dopaminergic system in reward learning - at the single neuron level! 🧠🖥️ #EEG #neuroskyence

www.biorxiv.org/content/10.1...

Confocal images of the fruit fly proventriculus, where the foregut meets the midgut

🪰My personal favorite “understudied” anatomical structure of the fruit fly #drosophila is the “proventriculus” (AKA the cardia), where the foregut meets the midgut. Here are #confocal images of various Gal4 lines, green. Blue is DAPI (DNA), magenta is phalloidin (f-actin).

Starting the week strong! Cheering myself up for the next challenges with 15 min of axonal growth cone dynamic madness. F-actin (cyan) and membrane (magenta) show their dance. One image taken every 10 s.🧠🔬
#MicroscopyMonday #LiveImaging #Neuroscience #Microscopy

Quiescent neural stem cells transiently become 'neurons' to coordinate reactivation https://www.biorxiv.org/content/10.1101/2024.11.19.624366v1 Reactivation of quiescent neural stem cells (qNSCs) is a coordinated process that generates new neur

Quiescent neural stem cells transiently become 'neurons' to coordinate reactivation https://www.biorxiv.org/content/10.1101/2024.11.19.624366v1

A synthetic platform for multiplex screening of cell-cell communication between soil fungi https://www.biorxiv.org/content/10.1101/2024.10.30.620951v1 Fungi are essential members of natural ecosystems and industrial biotechnology, yet they also pose s

A synthetic platform for multiplex screening of cell-cell communication between soil fungi https://www.biorxiv.org/content/10.1101/2024.10.30.620951v1

It's like it's getting more and more exasperated when its suggestions aren't working. WHAT DO YOU MEAN YOU STILL HAVE A PROBLEM WELL THEN HAVE YOUR TRIED...