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Dan Belsky

@danbelsky.bsky.social

GeroScience, Population Health, Lifecourse. We build tools to measure aging and use them to investigate healthspan impacts of gerotherapeutics, environments, social policies

75 Followers  |  87 Following  |  13 Posts  |  Joined: 20.11.2024  |  2.1221

Latest posts by danbelsky.bsky.social on Bluesky

So much more to do! Data are freely available for research purposes. Applications required to establish data security protocols, etc. Please reach out with questions if you need help getting access.

14.12.2024 17:46 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Fig. 6: Differential adipose mRNA expression between caloric restriction and ad libitum groups at 12- and 24-month timepoints. | Nature Aging

And now in this database paper, broad evidence for down-regulation of inflammation in adipose tissue www.nature.com/articles/s43...

14.12.2024 17:44 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: TheΒ CALERIE study Two years of sustained CR in humans positively affected skeletal muscle quality, and impacted gene expression and splicing profiles of biological pathways known to affected by CR in model organisms. ...

Changes in the muscle transcriptome parallel to mouse CR experiments onlinelibrary.wiley.com/doi/10.1111/...

14.12.2024 17:43 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial - Nature Aging Using samples and data from the CALERIE study, a human randomized controlled trial of long-term caloric restriction, the authors find that the intervention slows DunedinPACE, a DNA methylation measure...

Slowed pace of aging as measured by the DunedinPACE epigenetic clock, but no effect on the GrimAge, PhenoAge, or first-generation clocks www.nature.com/articles/s43...

14.12.2024 17:40 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis Abstract. Calorie restriction (CR) increases healthy life span and is accompanied by slowing or reversal of aging-associated DNA methylation (DNAm) changes

Key results include signs of epigenetic changes in the opposite direction from
obesity and smoking academic.oup.com/biomedgeront...

14.12.2024 17:38 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Motivated by these early findings, we generated a range of genomic data from stored blood, muscle, and adipose tissue to test for further signs of slowed biological aging.

14.12.2024 17:37 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge - GeroScience Methods to quantify biological aging are emerging as new measurement tools for epidemiology and population science and have been proposed as surrogate measures for healthy lifespan extension in gerosc...

See also link.springer.com/article/10.1...

14.12.2024 17:36 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis Abstract. Biological aging measures have been proposed as proxies for extension of healthy life span in trials of geroprotective therapies that aim to slow

In early work we found that intervention slowed increases in blood-chemistry indices of biological aging academic.oup.com/biomedgeront...

14.12.2024 17:35 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial 2 years of moderate calorie restriction significantly reduced multiple cardiometabolic risk factors in young, non-obese adults. These findings suggest the potential for a substantial advantage for cardiovascular health of practicing moderate calorie restriction in young and middle-aged healthy individuals, and they offer promise for pronounced long-term population health benefits.

www.thelancet.com/journals/lan...

14.12.2024 17:34 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity AbstractBackground. Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species. The implications for

The trial found large impacts on weight loss and indicators of cardiometabolic health academic.oup.com/biomedgeront...

14.12.2024 17:33 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Home | CALERIEDuke University School of Medicine

CALERIE is the first ever RCT of calorie restriction in non-obese healthy human adults calerie.duke.edu

14.12.2024 17:31 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
AgingResearchBiobank AgingResearchBiobank provides a state-of-the-art inventory system for the storage and distribution of NIA collections to the broader scientific community.

Get the data at agingresearchbiobank.nia.nih.gov

14.12.2024 17:29 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0
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The CALERIE Genomic Data Resource - Nature Aging Ryan and colleagues present multi-tissue, multi-omics, longitudinal datasets from the CALERIE phase 2 randomized controlled trial of caloric restriction in humans, providing a powerful resource for tr...

The CALERIE Genomic Data Resource is up www.nature.com/articles/s43...

14.12.2024 17:29 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

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